Publications by authors named "Guido Klingbeil"

Article Synopsis
  • The text includes a collection of research topics related to neural circuits, mental disorders, and computational models in neuroscience.
  • It features various studies examining the functional advantages of neural heterogeneity, propagation waves in the visual cortex, and dendritic mechanisms crucial for precise neuronal functioning.
  • The research covers a range of applications, from understanding complex brain rhythms to modeling auditory processing and investigating the effects of neural regulation on behavior.
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The stochastic simulation algorithm (SSA) was introduced by Gillespie and in a different form by Kurtz. Since its original formulation there have been several attempts at improving the efficiency and hence the speed of the algorithm. We briefly discuss some of these methods before outlining our own simple improvement, the recycling direct method (RDM), and demonstrating that it is capable of increasing the speed of most stochastic simulations.

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Motivation: The importance of stochasticity in biological systems is becoming increasingly recognized and the computational cost of biologically realistic stochastic simulations urgently requires development of efficient software. We present a new software tool STOCHSIMGPU that exploits graphics processing units (GPUs) for parallel stochastic simulations of biological/chemical reaction systems and show that significant gains in efficiency can be made. It is integrated into MATLAB and works with the Systems Biology Toolbox 2 (SBTOOLBOX2) for MATLAB.

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