Species sensitivity distribution of rare earth elements: A full overview.

Rare earth elements (REEs) encompass 15 lanthanides and play a crucial role in modern technology. Despite their essential uses, REEs are emerging environmental contaminants due to their growing presence in industrial, agricultural, and medical applications. For the first time, the species sensitivity distribution (SSD) approach was applied to REEs considering 58 papers including toxicity about Ce, Dy, Er, Gd, La, Lu, Nd, Pr, Sm, and Y.

Ovarian reserve, metabolic and neuroendocrine profiles of cadets from Air Force Academy: a pilot study.

Background: Intensive physical activity and rigid dietary regimes can act as modifiers of neuroendocrine axes in women, inducing hormonal disorders and related menstrual irregularities such as functional hypothalamic amenorrhea (FHA). It would be important to evaluate if such disturbances may worsen female fertility. The aim of this study was to evaluate ovarian reserve markers and neuroendocrine axis in young military academy female cadets with years of training and occurrence of FHA.

Nutritional Composition, Fatty Acid Content, and Mineral Content of Nine Sorghum () Inbred Varieties.

is a self-pollinating species belonging to the Poaceae family characterized by a resistance to drought higher than that of corn. Sorghum ( L. Moench) has been grown for centuries as a food crop in tropical areas where it has an increasing importance, particularly as a cereal option for people with celiac disease.

Corrigendum: The molecular tumor board as a step in cancer patient management: a southern Italian experience.

[This corrects the article DOI: 10.3389/fmed.2024.

Pathological Changes and CYP1A1 Expression as Biomarkers of Pollution in Sarpa Salpa and Diplodus Sargus.

In a marine ecosystem, the most sensitive organisms to environmental changes, mainly to anthropic pressures, are fishes and invertebrates. Therefore, they are considered the ideal targets to indirectly evaluate the health of an entire ecosystem. Teleost fishes, particularly those that occupy the highest trophic levels, can accumulate toxic substances through their diet.

DNA methylation analysis of multiple genes in thymic epithelial tumors.

To investigate DNA methylation levels of a panel of genes in thymic epithelial tumors (TETs). We selected 15 genes among the most promising epigenetic biomarkers of TETs and evaluated their methylation levels in 71 TET samples. thymic carcinomas (TCs) showed hypermethylation of and genes and reduced methylation levels compared with thymomas (TMs) and healthy thymic tissues.

Trophic organization of the benthic communities off the South Italian coasts: A review with a modelistic approach.

Limited data are available about the coastal ecology of the Calabria region, in the southern Italy. As well, data about the levels of biodiversity and the structure of food webs in these environments are totally missing. However, considering the wide range of physical and ecological conditions distinguishing these ecosystems, a remarkable spread of biodiversity is expected.

inhibitors: an updated patent review (2021-present).

Introduction: Tuberculosis (TB) remains a major global health issue, causing around 10 million new cases and 1.3 million deaths in 2022. The challenge is compounded by multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB strains, and co-infection with HIV.

Ecotoxicity and Mutagenicity Assessment of Novel Antifungal Agents VT-1161 and T-2307.

Antifungal substances are essential for managing fungal infections in humans, animals, and plants, and their usage has significantly increased due to the global rise in fungal infections. However, the extensive application of antifungal agents in pharmaceuticals, personal care products, and agriculture has led to their widespread environmental dissemination through various pathways, such as excretion, improper disposal, and agricultural runoff. Despite advances in wastewater treatment, many antifungal compounds persist in the environment, affecting non-target organisms and contributing to resistance development.

A multi-disciplinary approach based on chemical characterization of foreshore sediments, ecotoxicity assessment and statistical analyses for environmental monitoring of marine-coastal areas.

The present work aims at providing a multi-disciplinary approach for environmental monitoring in marine-coastal areas. A monitoring campaign of 13 months (October 2022-October 2023) was carried out on sandy foreshore sediments (SFSs). The SFSs were analysed for potentially toxic elements (PTEs) and rare earth elements (REEs) content determination.

Ecotoxicological and metabolomic investigation of chronic exposure of Daphnia magna (Straus, 1820) to yttrium environmental concentrations.

In order to estimate the effects on aquatic organisms of long-term exposure to low doses of yttrium (Y) as a potential emerging contaminant, ecotoxicological and metabolomic data were collected on the model organism Daphnia magna, a keystone species in freshwater ecosystems. Following an initial acute toxicity assessment, a 21-day chronic exposure experiment was conducted using a sublethal concentration of 27 μg L⁻¹ of Y, corresponding to the effective concentrations inducing 10 % effect (EC) value for mortality endpoint and simulating the environmental Y level in aquatic systems. Results from the 21-day two-factor experiment combining microcrustacean survival, growth and reproduction bioassays and targeted gas chromatography-mass spectrometry (GC-MS) metabolomics indicated significant adverse effects of chronic exposure to Y on D.

The molecular tumor board as a step in cancer patient management: a southern Italian experience.

Introduction: The management of cancer patients follows a Diagnostic Therapeutic and Care Pathway (PDTA) approach, aimed at achieving the optimal balance between care and quality of life. To support this process, precision medicine and innovative technologies [e.g.

Sequencing of Checkpoint or BRAF/MEK Inhibitors on Brain Metastases in Melanoma.

Background: The impact of the order of treatment with checkpoint inhibitors or BRAF/MEK inhibitors on the development of brain metastases in patients with metastatic unresectable V600-mutant melanoma is unknown. The SECOMBIT trial examined the impact of the order of receipt of these treatments in such patients.

Methods: In this three-arm trial, we reviewed patients without brain metastases who received the BRAF/MEK inhibitors encorafenib and binimetinib until they had progressive disease followed by the immune checkpoint inhibitors ipilimumab and nivolumab (arm A); or treatment with ipilimumab and nivolumab until they had progressive disease followed by encorafenib and binimetinib (arm B); or treatment with encorafenib and binimetinib for 8 weeks followed by ipilimumab and nivolumab until they had progressive disease followed by retreatment with encorafenib arm binimetinib (arm C).

Characterization of a typical urban soil in terms of natural radionuclide content. The case study of a university campus.

A first comprehensive survey was carried out in a university campus in Italy in order to investigate in terms of natural elements an area where medium-high values of natural radiation are expected because of its peculiar geological features. The content of terrestrial radionuclides in 20 topsoil samples from the campus was determined with the aim to provide an important database of the soil characteristics. Ra, Th, and K concentrations were analysed by High Purity Germanium (HPGe) gamma-ray spectrometer in order to determine the background levels of natural radionuclides characteristics of the original area.

Assessment of ecological risks posed by veterinary antibiotics in European aquatic environments: A comprehensive review and analysis.

The extensive use of antibiotics in human and veterinary medicine has led to the emergence of antibiotic contaminants in the environment, posing significant risks to ecosystems and public health. This contamination arises from the persistence of antibiotics in aquatic environments, particularly in aquifer systems, where they contribute to the growing threat of antibiotic resistance. Despite increasing research, the understanding of the ecological and human health implications of these contaminants remains incomplete.

An artificial intelligence-based model exploiting H&E images to predict recurrence in negative sentinel lymph-node melanoma patients.

Background: Risk stratification and treatment benefit prediction models are urgent to improve negative sentinel lymph node (SLN-) melanoma patient selection, thus avoiding costly and toxic treatments in patients at low risk of recurrence. To this end, the application of artificial intelligence (AI) could help clinicians to better calculate the recurrence risk and choose whether to perform adjuvant therapy.

Methods: We made use of AI to predict recurrence-free status (RFS) within 2-years from diagnosis in 94 SLN- melanoma patients.

Cochlear implants for hereditary ATTR amyloidosis: a case report of two cases.

Purpose: To analyze the clinical presentation, management, and outcome of two sisters affected by hereditary transthyretin related amyloidosis (ATTRv) and bilateral severe-to-profound hearing loss treated with cochlear implant.

Methods: A description of two patients underwent three cochlear implant (CI) surgery was performed. Age at time of implantation ranged from 48 to 53 years.