Association between sarcopenic obesity and risk of frailty in older adults: a systematic review and meta-analysis.

Background: Age-related changes in body composition such as muscle loss can lead to sarcopenia, which is closely associated with frailty. However, the effect of body fat accumulation on frailty in old age remains unclear. In particular, the association between the combination of these two conditions, known as sarcopenic obesity, and frailty in older adults is unclear.

Aerobic exercise training attenuates ischemia-reperfusion injury in mice by decreasing the methylation level of METTL3-associated m6A RNA in cardiomyocytes.

Background And Aims: Ischemic heart disease (IHD) presents a significant global health challenge, with myocardial ischemia-reperfusion injury (MIRI) being a major pathophysiological contributor and lacking effective interventions. While aerobic exercise training (AET) enhances cardiovascular health, its protective mechanism in MIRI remains elusive. This study aims to elucidate the protective effect of AET in MIRI and its underlying mechanism.

Effects of Virtual Reality-Based Activities of Daily Living Rehabilitation Training in Older Adults With Cognitive Frailty and Activities of Daily Living Impairments: A Randomized Controlled Trial.

Objectives: Cognitive frailty, which is notably prevalent in nursing homes, correlates with a range of adverse health outcomes; however, interventions targeting this population are scarce, particularly those addressing activities of daily living (ADLs). The objective of this study was to evaluate the effects of virtual reality-based ADL rehabilitation training on older adults with cognitive frailty and ADL impairments.

Design: A 2-arm randomized controlled trial.

Association between adverse childhood experiences and mortality: A systematic review and meta-analysis.

Adverse childhood experiences represent a critical public health concern that warrants urgent attention and cannot be overlooked. The evidence regarding the relationship between adverse childhood experiences and mortality has been insufficient and inconsistent. To address this gap, we conducted a systematic review and meta-analysis to explore the association between adverse childhood experiences, including their subtypes, and various mortality outcomes.

Injectable self-healing alginate/PEG hydrogels cross-linked via thiol-Michael addition bonds for hemostasis and wound healing.

In this study, an alginate/PEG hydrogel was developed via a thiol-Michael addition reaction between oxidized quinone of catechols on dopamine-grafted sodium alginate (SA-DA) and sulfhydryl groups of 4-arm polyethylene glycol tetra-thiol (4-arm PEG-SH) under mildly basic conditions. Through the formation of thiol-terminated catechol groups, the accompanying oxidized catechols are reduced, significantly strengthening the internal network structure of the hydrogel and improving tissue adhesion. Meanwhile, the hydrogels have excellent self-healing properties due to the dynamic non-covalent bonds between the groups.

The effectiveness of the comprehensive geriatric assessment for older adults with frailty in hospital settings: A systematic review and meta-analysis.

Background: Comprehensive geriatric assessment (CGA) is performed by a multidisciplinary team and includes systematic comprehensive team assessment and treatment. Comprehensive geriatric assessment has become a fundamental component of geriatric nursing, as a multidimensional approach is necessary to achieve the best diagnosis and therapy for older adults with frailty.

Objective: The aim of our review was to analyze the effects of comprehensive geriatric assessment interventions on older adults with frailty in hospital settings.

Effects of nurse-led interventions on the physical and mental health among pre-frail or frail older adults: A systematic review.

Background: Globally, there is an increase in the number of older people living with frailty, thus effective strategies to prevent and manage frailty are of paramount importance. The effects of nurse-led interventions on the physical and mental health of (pre) frail people have not yet been systematically reviewed.

Methods: We searched the PubMed, Web of Science, EMBASE, CINAHL, and the Cochrane Library from inception to 8 May 2024.

Understanding the Transcription Factor NFE2L1/NRF1 from the Perspective of Hallmarks of Cancer.

Cancer cells subvert multiple properties of normal cells, including escaping strict cell cycle regulation, gaining resistance to cell death, and remodeling the tumor microenvironment. The hallmarks of cancer have recently been updated and summarized. Nuclear factor erythroid 2-related factor 1 (NFE2L1, also named NRF1) belongs to the cap'n'collar (CNC) basic-region leucine zipper (bZIP) family.

Effectiveness of integrated care for older adults-based interventions on depressive symptoms: A systematic review and meta-analysis.

Aim: To pool existing studies to assess the overall effectiveness of integrated care for older adults (ICOPE)-based interventions in improving depressive symptoms in older adults.

Design: A systematic review and meta-analysis.

Data Sources: Ten databases were systematically searched from inception to 15 July 2023 and the search was last updated on 2 September 2023.

Thermal-Induced Microstructure Deterioration of Egyptian Granodiorite and Associated Physico-Mechanical Responses.

Mineral transformations often induce microstructural deteriorations during temperature variations. Hence, it is crucial to understand why and how this microstructure weakens due to mineral alteration with temperature and the correlated physical and mechanical responses. Therefore, in this study, physical, chemical, thermal, petrographic, and mechanical analyses were carried out to comprehend better the thermal behaviors of Egyptian granodiorite exposed to temperatures as high as 800 °C.

Prevalence of multidimensional frailty among community-dwelling older adults: A systematic review and meta-analysis.

Objective: The aims of this systematic review were to explore the pooled prevalence of multidimensional frailty assessed by the Tilburg Frailty Indicator among community-dwelling older adults.

Design: A systematic review and meta-analysis.

Methods: A comprehensive literature search was conducted across multiple databases, including PubMed, Web of Science, Embase, the Cochrane Library, CINAHL and three Chinese databases.

Synthesis of three cisplatin-conjugated asymmetric porphyrin photosensitizers for photodynamic therapy.

Photodynamic therapy provides a promising solution for treating various cancer types. In this study, three distinct asymmetric porphyrin-cisplatin complex photosensitizers (ZnPt-P1, ZnPt-P2, and ZnPt-P3) were synthesized, each having unique side chains. Through a set of experiments involving singlet oxygen detection and density functional theory, ZnPt-P1 was demonstrated to have excellent efficacy, exceeding that of ZnPt-P2 and ZnPt-P3.

Comparative Analysis of Volatile Compounds from Four Radish Microgreen Cultivars Based on Ultrasonic Cell Disruption and HS-SPME/GC-MS.

The ultrasonic cell disruption method was used to efficiently extract isothiocyanates and other volatile compounds from radish microgreens. A total of 51 volatiles were identified and quantified by headspace solid-phase micro-extraction and gas chromatography-mass spectrometry (HS-SPME/GC-MS) in four radish microgreen cultivars, mainly including alcohols, aldehydes, isothiocyanates, sulfides, ketones, esters, terpenes, and hydrocarbons. The correlation between cultivars and volatile compounds was determined by chemometrics analysis, including principal component analysis (PCA) and hierarchical clustering heat maps.

Liquid biopsy analysis of lipometabolic exosomes in pancreatic cancer.

Pancreatic cancer is characterized by its high malignancy, insidious onset and poor prognosis. Most patients with pancreatic cancer are usually diagnosed at advanced stage or with the distant metastasis due to the lack of an effective early screening method. Liquid biopsy technology is promising in studying the occurrence, progression, and early metastasis of pancreatic cancer.

Relationship Between Cognitive Frailty and Mortality in Older Adults: A Systematic Review and Meta-Analysis.

Objective: To synthesize the pooled mortality risk estimate and determine whether cognitive frailty is a predictor of mortality.

Design: A systematic review and meta-analysis.

Setting And Participants: The participants were community-dwelling older adults aged ≥60 years.

Multicomponent All-Carbon Cascade and Sequential Annulation: Construction of Functionalized Decalins.

The decalin skeleton is found in numerous bioactive molecules. The present study describes a multicomponent all-carbon cascade and sequential annulation involving benzoylacetonitrile derivatives and 2-arylidene-1,3-indanediones that yields highly functionalized decalin derivatives. The reaction strategy consisted of a consecutive Michael/Michael/tautomerization/Michael/Aldol annulation sequence and involved organic amine catalysts, mild conditions, and high stereoselectivity.

Lactate attenuates astrocytic inflammation by inhibiting ubiquitination and degradation of NDRG2 under oxygen-glucose deprivation conditions.

Background: Brain lactate concentrations are enhanced in response to cerebral ischemia and promote the formation of reactive astrocytes, which are major components of the neuroinflammatory response and functional recovery, following cerebral ischemia. NDRG2 is upregulated during reactive astrocyte formation. However, its regulation and function are unclear.

Effectiveness of interventions in older adults with cognitive frailty: a systematic review and meta-analysis of randomised controlled trials.

Background: interventions targeting older adults with cognitive frailty have grown rapidly in recent years with inconsistent findings. However, there is no meta-analysis that has synthesised pooled estimates.

Objective: to synthesise the pooled effect of current targeted interventions in older people with cognitive frailty.

Effects of virtual reality-based interventions on the physical and mental health of older residents in long-term care facilities: A systematic review.

Background: Older residents in long-term care facilities often experience physical and mental health problems along with vulnerability to psychological and social stressors. Due to the shortage of human resources, the application of virtual reality technology may be a new way to promote healthy aging for older residents in long-term care facilities.

Objectives: To identify the effects of virtual reality-based interventions for improving physical and mental health outcomes among older residents in long-term care facilities.

Concrete Strength Prediction Using Different Machine Learning Processes: Effect of Slag, Fly Ash and Superplasticizer.

Blast furnace slag (BFS) and fly ash (FA), as mining-associated solid wastes with good pozzolanic effects, can be combined with superplasticizer to prepare concrete with less cement utilization. Considering the important influence of strength on concrete design, random forest (RF) and particle swarm optimization (PSO) methods were combined to construct a prediction model and carry out hyper-parameter tuning in this study. Principal component analysis (PCA) was used to reduce the dimension of input features.

Personally tailored exercises for improving physical outcomes for older adults in the community: A systematic review.

Purpose: To identify the effects of personally tailored exercise programmes for improving physical outcomes amongst older people living in the community.

Methods: Four databases (the Cochrane Library, PubMed, EMBASE, and Web of Science) were searched (from inception until Jan 25th, 2022) for original articles. All studies were randomized controlled trials (RCTs) and quasi-experimental trials reporting the effects of personally tailored exercise programmes on physical outcomes.

Development and Comprehensive SPE-UHPLC-MS/MS Analysis Optimization, Comparison, and Evaluation of 2,4-Epibrassinolide in Different Plant Tissues.

A determination method for trace 24-epibrassinolide (EBL) in plant tissues was developed using ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The plant tissue samples were extracted using a methanol-formic acid solution, and the corresponding supernatant was purified with ODS C18 solid-phase extraction column. The extracts were separated using a Zorbax Eclipse Plus C18 (2.