Publications by authors named "Guibout P"
[Diffusion of trimethoprim and sulfamethoxazole into the pleural fluid].
Rev Mal Respir
January 1987
Article Synopsis
- The study measured the levels of Trimethoprim (TMP) and Sulfamethoxazole (SMZ) in pleural effusion and plasma in 7 patients during their first, third, and fifth days of treatment.
- The ratio of TMP in pleural fluid to plasma increased steadily, averaging 0.79 by 12 hours, while SMZ peaked at 8 hours on day one (0.53) and rose to 0.71 by day five.
- TMP levels in pleural fluid were found to be lower than typically seen in bronchial secretions, whereas SMZ levels were significantly higher.
The authors specify the contribution of pleural carcinoembryonic antigen (CEA) assay in the diagnosis of malignant pleuritis by comparing it to plasma concentrations and pathologic findings. 45 patients with pleuritis were studied. Etiology was malignant in 15 and non-malignant in 27.
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- Pulmonary biopsies were performed on 16 patients with difficult diagnostic issues using thoracoscopy.
- The authors successfully diagnosed 14 cases involving diffuse or localized lung pathology, and these diagnoses aligned with the patients' disease progression.
- The procedure was safe, with no major incidents reported.
Article Synopsis
- The authors present 4 new cases of bronchial granular cell tumors, which are typically slow-growing and benign.
- Surgical intervention remains the primary and most effective treatment option, while endoscopic methods and chemotherapy are considered in specific situations.
- They document one instance where chemotherapy led to the complete disappearance of a granular cell bronchial tumor.
Article Synopsis
- The authors recommend using a small-diameter, opaque-to-X-rays drain called "Pleurocath" for draining pleural cavities.
- They explain the insertion technique and aftercare guidelines, emphasizing its effectiveness in treating conditions like pneumothorax and purulent pleurisies.
- This method is user-friendly, efficient, causes minimal trauma, and is well tolerated by patients.