Publications by authors named "Guibing Ren"
Article Synopsis
- Acute myeloid leukemia (AML) with mixed-lineage leukemia (MLL) gene rearrangements is a severe form of blood cancer that needs new treatment strategies due to its poor prognosis.
- * The study highlights EP300 and CREBBP as important regulators in the development of MLL-r AML, demonstrating that inhibiting these proteins can effectively reduce the growth of MLL-r leukemia cells without affecting normal cells.
- * The findings suggest that targeting EP300/CREBBP could be a promising therapeutic approach to improve outcomes for patients with this aggressive subtype of leukemia.
Background: The goal of this study is to disclose the clinically significant genomic alterations in the Chinese and Western patients with intrahepatic cholangiocarcinoma.
Methods: A total of 86 Chinese patients were enrolled in this study. A panel of 579 pan-cancer genes was sequenced for the qualified samples from these patients.
Introduction: Intrahepatic cholangiocarcinoma (ICC) exhibited increasing incidence and mortality around the world, with a 35% five-year survival rate. In this study, the genetic alteration of primary ICC and metastasis ICC was exhibited to discover novel personalized treatment strategies to improve the clinical prognosis.
Methods: Based on 153 primary and 49 metastasis formalin-fixed paraffin-embedded ICC samples, comprehensive genomic profiling was carried out.
EFFECTS OF SALVIA MILTIORRHIZAE ON THE KIDNEY OF RATS WITH SEVERE ACUTE PANCREATITIS AND OBSTRUTIVE JAUNDICE.
Afr J Tradit Complement Altern Med
August 2017
Article Synopsis
- Severe acute pancreatitis (SAP) and obstructive jaundice (OJ) are serious health issues, and Salviae miltiorrhizae has shown potential in protecting organs in related animal models, though the mechanisms are still unclear.
- This study involved 288 rats to investigate the effects of Salviae miltiorrhizae injection on kidney function, focusing on factors like mortality rates, kidney-related serum markers and apoptosis-related proteins.
- Results indicated that treatment with Salvia miltiorrhizae led to significant improvements in kidney health, as evidenced by lower serum creatinine levels and reduced apoptosis in treated rats compared to control groups.
Evaluation of liver functional reserve by combining D-sorbitol clearance rate and CT measured liver volume.
World J Gastroenterol
September 2003
Aim: Our research attempted to evaluate the overall functional reserve of cirrhotic liver by combination of hepatic functional blood flow, liver volume, and Child-Pugh's classification, and to discuss its value of clinical application.
Methods: Ninety two patients with portal hypertension due to hepatic cirrhosis were investigated. All had a history of haematemesis and hematochezia, esophageal and gastric fundus varices, splenomegaly and hypersplenia.