Publications by authors named "Guibert N"
Article Synopsis
- This study investigates the incidence and treatment of malignant central airway obstruction (MCAO) in patients with metastatic non-bronchogenic solid cancers (NBC), revealing that 18% of a large cohort experienced this complication.
- It identifies key prognostic factors influencing survival post-therapeutic bronchoscopy (TB), such as histology, performance status, and previous treatments.
- The findings suggest that TB effectively alleviates symptoms and prolongs survival for these patients, highlighting the need for timely referrals for bronchoscopic interventions.
Background And Objective: EpiGETIF is a web-based, multicentre clinical database created in 2019 aiming for prospective collection of data regarding therapeutic rigid bronchoscopy (TB) for malignant central airway obstruction (MCAO).
Methods: Patients were enrolled into the registry from January 2019 to November 2022. Data were prospectively entered through a web-interface, using standardized definitions for each item.
Article Synopsis
- The investigation of peripheral pulmonary lesions (PPLs) is complex, and an international survey was conducted to assess how interventional pulmonologists (IPs) are currently handling these cases.
- The survey received responses from 312 IPs across Europe, North America, and Asia, highlighting that many perform over 100 endoscopic procedures annually, with common practices including the use of rapid on-site evaluation and a variety of techniques such as radial EBUS and fluoroscopy.
- Significant differences exist in the use of advanced modalities like robotic bronchoscopy and cone-beam CT, primarily utilized in the USA, while half of the IPs without access to endoscopic treatments intend to acquire them in the near future.
Background And Objective: Traditionally, the diagnosis of acute rejection (AR) relies on invasive transbronchial biopsies (TBBs) to obtain histopathological samples. We aimed to evaluate the diagnostic yield of probe-based confocal laser endomicroscopy (pCLE) as a complementary and non-invasive tool for ACR screening, comparing its results with those obtained from TBBs.
Methods: Between January 2015 and April 2022, we conducted a retrospective study of all lung transplant recipients aged over 18 years at Toulouse University Hospital (France).
Background: Road accidents are the leading type of work-related fatalities, but the impact of work-related travel on overall traffic safety has been scarcely studied.
Objective: The main objective of the present study was to assess drivers' relative road accident risk between work-related and personal journeys.
Methods: A responsible/non-responsible case-control study was performed on a sample of 7,051 road accidents in France from the VOIESUR project.
Objectives: This study describes data from bronchoscopy performed at the diagnosis of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).
Methods: We conducted a retrospective study between 2004 and 2019 in patients aged >18 years with a diagnosis of microscopic polyangiitis (MPA) or granulomatosis with polyangiitis (GPA) who underwent bronchoscopy at onset of the disease. We collected bronchoalveolar lavage (BAL) and histological findings obtained during bronchoscopy.
Purpose: This review aimed to summarise evidence about the impact of pharmacological and non-pharmacological interventions on survival in COPD patients.
Methods: We performed a narrative literature review on the effect of pharmacological and non-pharmacological interventions on survival in COPD patients.
Results: Inhaled therapies are central to reduce symptoms in COPD.
Guidelines for the management of chronic cough in adults. Endorsed by the French speaking society of respiratory diseases (Société de Pneumologie de Langue Française, SPLF), the Société Française d'Oto-Rhino-Laryngologie et de Chirurgie de la Face et du Cou (SFORL), the Société Française de Phoniatrie et de Laryngologie (SFPL), the Société Nationale Française de Gastro-entérologie (SNFGE).
Respir Med Res
June 2023
Patients with chronic cough experience a high alteration of quality of life. Moreover, chronic cough is a complex entity with numerous etiologies and treatments. In order to help clinicians involved in the management of patients with chronic cough, guidelines on chronic cough have been established by a group of French experts.
View Article and Find Full Text PDFPatients with chronic cough experience major alteration in their quality of life. Given its numerous etiologies and treatments, this disease is a complex entity. To help clinicians involved in patient management of patients, guidelines have been issued by a group of French experts.
View Article and Find Full Text PDFBackgroundTo cope with the persistence of the COVID-19 epidemic and the decrease in antibody levels following vaccination, a third dose of vaccine has been recommended in the general population. However, several vaccine regimens had been used initially for the primary vaccination course, and the heterologous Vaxzevria/Comirnaty regimen had shown better efficacy and immunogenicity than the homologous Comirnaty/Comirnaty regimen.AimWe wanted to determine if this benefit was retained after a third dose of an mRNA vaccine.
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- - Macrophages play a crucial role in HIV-1 infection and serve as significant viral reservoirs, particularly in various tissues where they are not easily infected by free virus.
- - The study reveals that HIV-1 can efficiently infect macrophages through cell fusion with infected CD4+ T cells, highlighting a critical method of viral transmission in vivo.
- - This fusion process varies based on the polarization state of the macrophages and is regulated by a specific adhesion structure and the CD81 tetraspanin, which influences cellular contractility during the infection.
Article Synopsis
- The study examines how different vaccination methods and previous infection histories affect immune memory in people vaccinated against SARS-CoV-2.
- It finds that individuals with hybrid immunity (those who recovered from COVID-19 and then got vaccinated) have the highest levels of antibodies six months post-vaccination, compared to those who were vaccinated without prior infection.
- Additionally, hybrid immunity results in a more diverse memory B cell pool and enhances the functionality of T cell responses, suggesting better protection against the virus, especially at mucosal sites.
Background And Objective: Dynamic hyperinflation (DH) is a major marker of exertional dyspnoea in severe emphysema. We hypothesized that bronchoscopic lung volume reduction (BLVR) using endobronchial valves (EBVs) decreases DH.
Methods: In this prospective bi-centre study from both Toulouse and Limoges Hospitals, we assessed DH during an incremental cycle ergometry before and 3 months after EBVs treatment.
Background: Pectus excavatum (PE) is the most common congenital chest wall deformity, whose cardiopulmonary consequences are controversial. PE surgery is in our experience usually performed for aesthetic reasons.
Objectives: The aim of this study was to evaluate the impact of PE on respiratory function and exercise capacity in patients with PE before patient-specific silicone implant correction.
Background: Although the endobronchial valves (EBV) were successfully developed as treatment for severe emphysema, its main complication, pneumothorax, remained an important concern.
Objective: To assess whether the placement of Zephyr© endobronchial valves throughout 2 procedures instead of 1 minor the frequency of pneumothorax without lowering the benefits of such treatment.
Methods: This retrospective study was conducted in 15 pulmonology department in France.
Up to 30% of lung cancer patients suffer from central airway obstruction, resulting in major deterioration in prognosis and quality of life. Interventional bronchoscopy combines a number of invasive techniques used during rigid bronchoscopy. It is designed to rapidly improve symptoms, primarily dyspnea.
View Article and Find Full Text PDFKirsten rat sarcoma viral oncogene homolog (KRAS) gene encodes a GTPase that acts as a molecular switch for intracellular signal transduction, promoting cell growth and proliferation. Mutations in the KRAS gene represent important biomarkers for NSCLC targeted therapy. However, detection of KRAS mutations in tissues has shown some limitations.
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