High expression levels of FANCI correlate with worse prognosis and promote tumor growth of lung adenocarcinoma partly via suppression of M1 macrophages.

FANCI, a member of the Fanconi anemia (FA) complementation group, normally associates with FANCD2 to play an important role in ribosome biogenesis and DNA repair. However, the correlation of FANCI with prognostic value and the molecular mechanism in patients with lung adenocarcinoma (LUAD) remains unclear. In the present study, bioinformatics analysis was performed on LUAD data from TCGA and GEO databases, and further confirmed by in vitro experiments.

Identification of key pathways and genes in nasopharyngeal carcinoma based on WGCNA.

Objective: We aim to identify the potential genes and signaling pathways associated with the nasopharyngeal carcinoma (NPC) prognosis using Weighted Gene Co-Expression Network Analysis (WGCNA).

Methods: Gene Expression Omnibus (GEO) query was utilized to download two NPC mRNA microarray data. WGCNA was conducted on differentially expressed genes (DEGs) to obtain tumor-associated gene modules.

Expression and Biological Functions of EPC1 in Nasopharyngeal Carcinoma.

Background: Comb homolog enhancer 1 (EPC1) gene is one of the important members of epigenetic inhibitor PCG family. It shows carcinogenic potential in a variety of malignant tumors, but the expression and role of EPC1 in nasopharyngeal carcinoma are unclear. The aim of this study was to explore the expression and function of enhancer of polycomb homolog 1 (EPC1) in nasopharyngeal carcinoma (NPC).

The clinical value of three-dimensional measurement in the diagnosis of thoracic myelopathy caused by ossification of the ligamentum flavum.

Background: Thoracic ossification of the ligamentum flavum (OLF) is a major cause of thoracic myelopathy, which is often accompanied by multiple segmental stenosis or other degenerative spinal diseases. However, in the above situations, it is difficult to determine the exact segment responsible. The objective of this study was to analyze three-dimensional (3D) radiological parameters in order to establish a novel diagnostic method for discriminating the responsible segment in OLF-induced thoracic myelopathy, and to evaluate its superiority compared to the conventional diagnostic methods.

A biomarker-based prediction model for risk of locoregional recurrence in pathologic stage IIIA-N2 non-small cell lung cancer.

Objective: To investigate risk factors for locoregional recurrence (LRR) of pathologic stage IIIA-N2 non-small cell lung cancer (pIIIA-N2 NSCLC) and construct a prediction model for risk score to determine a patient's risk for LRR and guide the selection of postoperative radiotherapy (PORT).

Methods: The clinical, pathologic, and biological data of 107 patients with pIIIA-N2 NSCLC treated at Fujian Provincial Hospital between May 2012 and December 2018 were analyzed retrospectively. None of the patients had positive surgical margins, and none received preoperative treatment or PORT.

Strategy for thermometry via Tm³⁺-doped NaYF₄ core-shell nanoparticles.

Optical thermometers usually make use of the fluorescence intensity ratio of two thermally coupled energy levels, with the relative sensitivity constrained by the limited energy gap. Here we develop a strategy by using the upconversion (UC) emissions originating from two multiplets with opposite temperature dependences to achieve higher relative temperature sensitivity. We show that the intensity ratio of the two UC emissions, ³F(2,3) and ¹G₄, of Tm³⁺ in β-NaYF₄:20%Yb³⁺, 0.

Synthesis and photoluminescent properties of NaYF4:Eu3+ core and NaYF4:Eu3+/NaYF4 core/shell nanocrystals.

NaYF4:Eu3+ core and NaYF4:Eu3+/NaYF4 core/shell nanocrystals (NCs) were synthesized via a wet chemical method. The transmission electron microscope photographs show that the core and core/shell nanoparticles are monodisperse and uniform NCs with average diameters of 22 and 26 nm respectively. The photoluminescence (PL) properties of the samples, including the PL excitation and emission spectra, and luminescent decay curves, are investigated in detail.

Pr(3+)-doped beta-NaYF4 for temperature sensing with fluorescence intensity ratio technique.

Pure beta-NaYF4:0.8%Pr3+ powder sample was synthesized by the hydrothermal method. The temperature dependence of the fluorescence intensity ratio (FIR) of emission bands corresponding to the 3P1 --> 3H5 and 3P0 --> 3H5 transitions was measured in the temperature range of 120 K to 300 K excited by a 473 nm continuous wave (CW) laser.

Energy transfer mechanisms in Yb3+-doped GdVO4 near-infrared downconversion nanophosphor.

Yb3+-doped GdVO4 nanophosphor was prepared by the co-precipitation method. Under ultraviolet (UV) light excitation, strong near-infrared (NIR) emission of Yb3+ (2F(5/2) --> 2F(7/2)) around 980 nm was observed. Owing to the host absorption of GdVO4, a broad excitation band ranging from 250 to 350 nm was recorded when the Yb3+ emission was monitored, which suggests an efficient energy transfer from the host to the Yb3+ ions.

Broadband downconversion in Bi3+, Yb3+-Co-doped YVO4 phosphor.

Yttrium vanadate phosphors co-doped with Bi3+ and Yb3+ ions have been prepared via the solid-state reaction. The phosphors were characterized by various methods including X-ray diffraction, photoluminescence excitation and photoluminescence spectra. Upon ultraviolet (UV) light excitation, an intense near-infrared (NIR) emission of Yb3+ corresponding to the transition of 2F(5/2) --> 2F(7/2) peaking at 985 nm was observed as a result of energy transfer from O2(-)-V5+ or Bi3+-V5+ charge transfer state (CTS) to Yb3+.

An effective polymer cross-linking strategy to obtain stable dispersions of upconverting NaYF4 nanoparticles in buffers and biological growth media for biolabeling applications.

Ligands on the nanoparticle surface provide steric stabilization, resulting in good dispersion stability. However, because of their highly dynamic nature, they can be replaced irreversibly in buffers and biological medium, leading to poor colloidal stability. To overcome this, we report a simple and effective cross-linking methodology to transfer oleate-stabilized upconverting NaYF(4) core/shell nanoparticles (UCNPs) from hydrophobic to aqueous phase, with long-term dispersion stability in buffers and biological medium.

[Preparation of Y2O3:Er3+ by coprecipitation method and influence of initial pH on the luminescent properties].

Samples of Y2O3:1%Er were prepared by coprecipitation method and the pH value of precipitant ammonium bicarbonate was adjusted by ammonia. Results of Fourier transform infrared spectra (FTIR) and elemental analysis showed that the chemical construction of precursors at pH range of 8.0-9.

[Preparation and luminescence of down-conversion material beta--NaYF4 : Tb3+, Yb3+].

NaYF4 : Tb3+, Yb3+ down-conversion (DC) phosphors were synthesized by hydrothermal method. X-ray diffraction (XRD), photoluminescence (PL) and photoluminescence excitation (PLE) spectra were used to characterize the samples. Experiment results revealed that samples of NaYF4 : Tb3+, Yb3+ crystallized in hexagonal shape without cubic shape.