Isolation of NH₄+-tolerant mutants of Actinobacillus succinogenes for succinic acid production by continuous selection.

Actinobacillus succinogenes, a typical succinic acid producing microorganism, was inhibited seriously by ammonium ion, which hampered industrialization of A. succinogenes with ammonium ion based material as the pH controller. In this study, we have isolated an ammonium ion-tolerant mutant of A.