Zhonghua Kou Qiang Yi Xue Za Zhi
September 2003
Objective: Bone marrow stromal cells (bMSCs) of rabbits transferred with mammalian hBMP-4 expression plasmid were used to construct tissue-engineered bone. Gene therapy combined with tissue-engineering technique was explored to further improve osteogenesis.
Methods: pEGFP-hBMP-4 plasmid was constructed by subcloning technique.