Publications by authors named "Gui-lai Chen"
Although platinum-based chemotherapy is the frontline regimen for colorectal cancer (CRC), drug resistance remains a major challenge affecting its therapeutic efficiency. However, there is limited research on the correlation between chemotherapy resistance and lipid metabolism, including PIK3CA mutant tumors. In this present study, we found that PIK3CA-E545K mutation attenuated cell apoptosis and increased the cell viability of CRC with L-OHP treatment and .
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- Breast cancer is the most common cancer among women, with 20-30% of patients facing metastasis after surgery and poor treatment responses despite advancements in therapies.
- CAR-T cell therapy, a promising immunotherapy, struggles with solid tumors like breast cancer due to the complexity of the tumor environment and a lack of ideal targets.
- The text discusses potential targets for CAR-T therapy in breast cancer (like HER-2 and EGFR), addresses challenges (such as off-target effects and tumor microenvironment issues), and suggests strategies to enhance this treatment approach.
Image-guided tumor ablation eliminates tumor cells by physical or chemical stimulation, which shows less invasive and more precise in local tumor treatment. Tumor ablation provides a treatment option for medically inoperable patients. Currently, clinical ablation techniques are widely used in clinical practice, including cryoablation, radiofrequency ablation (RFA), and microwave ablation (MWA).
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- Angiogenesis is vital in the early stages of tumor development and progression, making it important to study and inhibit.
- A zebrafish model was created to investigate angiogenesis and screen for new anti-angiogenic drugs, using glioma U87 cells that express a red fluorescent protein.
- The study found that TGF-β1 promotes glioma-induced angiogenesis through the JNK pathway, and this process involves macrophage infiltration, highlighting the model's potential for understanding tumor-related angiogenesis and drug discovery.