Anisodamine hydrobromide ameliorates cardiac damage after resuscitation.

The microcirculation is correlated with the prognosis of patients with cardiac arrest and changes after resuscitation. In the present study, the effects of anisodamine hydrobromide (AH) on microcirculation was investigated and its potential mechanisms were explored. A total of 24 pigs were randomly grouped into three groups (n=8): Sham, Saline and AH group.

Influence of Microcirculatory Dysfunction on Myocardial Injury after Cardiopulmonary Resuscitation.

Objective: This study aimed to examine the effects of microcirculatory dysfunction and 654-1 intervention after cardiopulmonary resuscitation on myocardial injury.

Methods: Landrace pigs were divided into a sham operation group (S group, = 6), ventricular fibrillation control group (VF-C group, = 8) and 654-1 intervention group (VF-I group, = 8). Hemodynamics was recorded at baseline, at recovery of spontaneous circulation (ROSC), and 1 h, 2 h, 4 h and 6 h thereafter.

[Clinical and laboratory features of macrophage activation syndrome].

Objective: To study the clinical and laboratory features of macrophage activation syndrome (MAS) at the early stage of diagnosis, and to explore a method for early identification of MAS.

Methods: A retrospective analysis was performed for the demographic data, clinical and laboratory features, and treatment outcomes of 21 MAS patients.

Results: Of the 21 MAS patients, 14 had systemic juvenile idiopathic arthritis, 5 had Kawasaki disease (KD), and 2 had connective tissue disease (CTD) as primary diseases.

Study on the neurotoxic effects of low-level lead exposure in rats.

Objective: To investigate effects of developmental lead exposure on nitric oxide synthase (NOS) activity in different brain regions and on N-methyl-D-aspartate (NMDA) receptor mRNA expression in the hippocampus of rats. On the basis of these observations, we explored possible mechanisms by which lead exposure leads to impaired learning and memorizing abilities in children.

Methods: A series of rat animal models exposed to low levels of lead during the developing period was established (drinking water containing 0.

[Effects of lead exposure on nitric oxide synthase activity in different brain regions of developmental rat].

Objective: To observe the influence of lead exposure on the activity of nitric oxide synthase (NOS) in different brain regions of rat.

Methods: By establishing a series of rat models exposed to different low levels of lead (drinking water containing 0.025%, 0.