Publications by authors named "Gui-chen Wang"
The immune injury effects and clinical significance of eosinophils in auto-immune-related hematocytopenia.
J Immunoassay Immunochem
September 2015
Eosinophils (EOS) quantity, active state, peroxidase activity (POX), and HLA-DR expression in bone marrow of 176 Auto-Immune-Related Hematocytopenia (AIRH) patients were analyzed. Immunofluorescent staining (IF) is performed to observe the expression of immunizing molecules on EOS. In serum of AIRH patients the levels of IL-4, IL-5, IL-6, IL-12, IL-17, and IFN- γ were increased but there was no significance on IL-2 level.
View Article and Find Full Text PDFBackground: Immune-related hematocytopenia (IRH) is considered to be related with the production of autoantibody, as well as the activation of humoral immunity which is stimulated by B lymphocyte. This study aimed to observe the levels of various cytokines in the blood serum and the in situ active state of macrophage (Mφ) in the medullary hematopoietic microenvironment of IRH patients, and to probe into the immune mechanism and clinical significance of Mφ in hematopoietic cell injury.
Methods: ELISA is used to detect the IL-4, IL-6, IL-12, IL-17, and IFN-γ levels in the peripheral blood serum of 376 patients in pre- and post-therapy.
Article Synopsis
- The study aims to understand how eosinophilic granulocytes (EOS) affect anti-leukemic responses in chronic myelogenous leukemia (CML) patients.
- Elevated serum levels of IL-12 and IL-17 were observed in CML patients, especially in those with activated EOS, suggesting a link between these cytokines and the immune response.
- Activated EOS in the bone marrow can attack leukemic cells through mechanisms like adhesion and phagocytosis, and they express cytokines IL-12 and IL-17, indicating their potential role in combating leukemia.