Publications by authors named "Gui-Ying Li"
As an emerging niche colonized by microorganisms, microplastics may selectively enrich pathogens, resulting in crucial ecological risks and potential threats to public health in aquatic environments. However, the enrichment characteristics and ecological risks of pathogens on different microplastic biofilms remain unclear. In this study, 16S rRNA high-throughput sequencing technology was used to investigate the differences in the bacterial community structure, occurrence characteristics of pathogens, and prediction of ecological risks on five typical microplastic biofilms of polyethylene （PE）, polypropylene （PP）, polystyrene （PS）, polyethylene terephthalate （PET）, and polyvinyl chloride （PVC） through a field in-situ incubation experiment.
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- Scylla paramamosain, an important crab species in aquaculture, is increasingly threatened by the highly pathogenic mud crab dicistrovirus-1 (MCDV-1), which disrupts its cultivation due to viral diseases.
- A study analyzed the immune response of infected mud crabs, revealing 5,139 differentially expressed genes and highlighting pathways related to humoral immunity that the crabs activate to combat MCDV-1, while also showing disruptions in metabolic processes.
- The research identified 9 key hub genes linked to viral endocytosis, indicating that MCDV-1 may utilize this process to enter crab cells and replicate, marking a significant step in understanding the viral
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- Anti-inflammatory and angiogenesis factors play critical roles in wound healing, requiring specialized dressings for effective treatment.
- A novel near-infrared (NIR)-responsive hydrogel dressing was developed, incorporating nanoparticles and compounds that allow for controlled drug release.
- In vivo tests showed this dressing significantly improved wound healing rates, achieving 96% recovery in 11 days, indicating its potential as a superior treatment for wound infections.
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- * The experiment involved comparing serum samples from DN patients and healthy volunteers, using mouse models induced with diabetes to study the effects of transgelin-2 on kidney cells.
- * Results showed that higher levels of transgelin-2 are linked to increased inflammation and reduced E-cadherin activity in DN, suggesting it plays a crucial role in the disease process through the ANXA2/STAT3 signaling pathway.
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- - Grain sorghum has been important for global food security since ancient times and is expected to play a bigger role in food and energy security, especially with improved management techniques across different ecological zones.
- - A study in China over two years explored the impact of ecological zones, variety, and plant spacing on sorghum yield, finding that ecological type was the most significant factor affecting yield variance (49.8%), while variety and plant spacing had lesser impacts.
- - The growth duration of sorghum was mainly influenced by the ecological type and varied by region, as well as the variety's origin, with all tested varieties maturing in 94-108 days before fall sowing, although row spacing configurations did not significantly affect
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- Sorghum is a crucial crop for food security in dry regions due to its resilience to challenges like poor soil and pests, making it suitable for low-fertility lands.
- A two-year study in China explored how different factors—like variety, location, sowing dates, and plant density—affect sorghum yields, revealing that location had the largest impact, followed by variety, while factors like sowing date and density contributed less.
- The research concluded that mid-maturing sorghum varieties are preferable in spring sowing early maturing areas, as they perform better under varying climate conditions during critical growth stages.
The (co)variance components and corresponding phenotypic and genetic parameters for growth traits and wool traits of economic importance were estimated in the Alpine Merino sheep population maintained at Gansu Provincial Sheep Breeding Technology Extension Station in northwestern China. Data from a maximum of 49,474 animals sired by 526 rams and born from 22,531 ewes over 20 years from 2000 to 2019 were used in this study. Birth type, age of dam, birth year, sex and/or management group, and age at measurement were initially fitted as fixed effects in an animal model with various random effects.
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- The sorghum soluble acid invertase gene, SbSAI-2, was cloned from the BTx623 variety and found to significantly impact sugar composition and content in stem juice.
- This study identified two transcripts of SbSAI-2, with one producing an active protein, revealing a 72% similarity to the OsVIN2 gene in rice.
- Experiments showed that overexpressing SbSAI-2 increased invertase activity and altered sugar levels in stems, decreasing sucrose while increasing glucose and fructose significantly, confirming its crucial role in sucrose metabolism.
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- Sugar metabolism is essential for plant growth, and invertases are key enzymes that regulate this process and crop yield.
- Research focused on soluble acid invertase in sweet sorghum revealed significant differences in gene sequences among various sorghum parent lines and hybrid varieties, particularly between B-lines and restore lines.
- The study found that as sorghum breeding progresses, the haplotype of the invertase gene changes, potentially contributing to yield gains, and shorter gene sequences were observed, indicating enhanced gene efficiency for breeding.
[A Study on the Role and Mechanism of Fenofibrate in Mice Renal Fibrosis Induced by Unilateral Ureteral Obstruction].
Sichuan Da Xue Xue Bao Yi Xue Ban
September 2020
Article Synopsis
- The study aimed to explore how fenofibrate affects renal fibrosis caused by unilateral ureteral obstruction (UUO) in mice, suggesting it could be a potential treatment option.
- The experiment involved 31 adult male mice, divided into three groups: a control group (Sham), a UUO group, and a UUO group treated with fenofibrate (UUO+Feno), to analyze biochemical and histological changes after treatment.
- Results indicated that fenofibrate treatment significantly reduced serum creatinine and blood urea nitrogen levels in the UUO+Feno group compared to the UUO group, hinting at its protective role against kidney damage.
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- Researchers studied heavy metal pollution from traffic in Lanzhou City by measuring metal elements in soil using an atomic absorption spectrophotometer.
- Results indicated significant increases in heavy metals like chromium, zinc, copper, and nickel, with chromium, copper, and lead marked as moderate pollutants, while the potential ecological risk ranking was Cu>Pb>Cr>Ni>Zn>Mn.
- Certain greening plants, like Sophora japonica and Rosa chinesis, showed different abilities to accumulate these metals, with higher chlorophyll and calcium levels in some species suggesting they might thrive in polluted areas.
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- The paper discusses the role of condensins in chromosome condensation and segregation during cell cycles, highlighting their components and structures.
- It reviews recent studies showing that subunits of condensin I and II may be involved in human cancers, suggesting they could be potential targets for cancer therapies.
- Despite the lack of direct documentation linking hCAP-D2 (a subunit of condensin I) to human cancers, the review proposes that it, along with all condensin subunits, could be explored as therapeutic targets for cancer treatment.
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- Long non-coding RNAs, particularly urothelial carcinoma-associated 1 (UCA1), are identified as significant regulators in cancer development and progression, with UCA1 acting as an oncogene in various tumors.
- In renal cell carcinoma, UCA1 is overexpressed in cancer tissues compared to normal ones, and its high levels correlate with advanced disease stages and poor patient survival.
- The study reveals that reducing UCA1 levels inhibits cancer cell growth and increases the expression of the p21 protein, suggesting that targeting UCA1 may provide a new treatment strategy for renal cell carcinoma patients.
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- The study aimed to evaluate the effectiveness of ozone therapy combined with Fugui Gutong Granule (FGG) in treating middle-aged and aged patients with knee osteoarthritis (KOA) caused by yang-deficiency induced cold-damp syndrome (YDICDS).
- A randomized controlled trial with 200 patients divided into four groups (control, FGG-only, ozone-only, and combined treatment) measured pain and physical function using VAS and WOMAC scores over a month of treatment.
- Results showed significant improvements in pain and joint function for the combined treatment group compared to the other groups, with a cure rate of 76% for the ozone plus FGG group, highlighting its effectiveness for KOA management.
IFN-γ induces lipogenesis in mouse mesangial cells via the JAK2/STAT1 pathway.
Am J Physiol Cell Physiol
April 2013
Article Synopsis
- The study examines how high mobility group box-1 (HMGB1) affects lipid buildup in mouse mesangial cells when stimulated by γ-interferon (IFN-γ), focusing on the JAK2/STAT1 signaling pathway's role.
- Results reveal that IFN-γ boosts lipid deposition and triggers the expression of proteins like SREBP-1 and FAS, while inhibiting SREBP-1 diminishes these effects.
- Furthermore, HMGB1 enhances SREBP-1 and FAS production, leading to increased lipid accumulation, and blocking the JAK2/STAT1 pathway reduces harmful lipid buildup caused by IFN-γ.
[Effects of langchuangping granule on the expression of B lymphocyte activating factor in the peripheral blood B cells of BXSB lupus nephritis mice].
Zhongguo Zhong Xi Yi Jie He Za Zhi
March 2012
Article Synopsis
- The study investigates the role of B lymphocyte activating factor (BAFF) in BXSB lupus nephritis mice to assess the effectiveness of Langchuangping Granule (LG) as a treatment.
- Researchers conducted experiments on mouse groups receiving different treatments and measured various health indicators, including urine protein and serum factors.
- Results showed that BAFF levels and other indicators were significantly higher in lupus mice, decreasing after treatment with LG or hormonal therapy, indicating BAFF as a potential target for lupus nephritis management.
[Langohuangping granule down-regulated monocyte chemoattractant protein-1 via suppressing nuclear factor kappa B signaling pathway in BXSB lupus nephritis mice].
Zhongguo Zhong Xi Yi Jie He Za Zhi
December 2011
Objective: To study whether Langchuangping granule (LG) could exert its renal protection by down-regulating monocyte chemoattractant protein-1 (MCP-1) via suppressing nuclear factor kappa B (NF-kappaB) signaling pathway in BXSB lupus nephritis (LN) mice. Methods Eighteen male 11-week-old BXSB LN mice were randomly divided into three groups, i.e.
View Article and Find Full Text PDF[Loss of the balance between Th17 and Th1 populations in HIV/AIDS patients].
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi
February 2010
Objective: To evaluate the Th17/Th1 response in HIV infected patients and the mutual relationship between the response of Th17 and Th1.
Methods: 38 chronic HIV infected patients as well as 24 healthy volunteers were performed in this study. The patients were divided into two groups, one group before treatment, the other after therapy.
[Clinical observation on hepatotoxicity of AIDS patients treated with HAART].
Zhonghua Gan Zang Bing Za Zhi
October 2009
Crosslinked starch phosphates (CSP) with different contents of phosphate groups were used to adsorb Zn(II) from aqueous solution. Effects of adsorption time, initial concentration of Zn(II) ion, and temperature on the adsorption of Zn(II) by CSP were studied, and the equilibrium, thermodynamics and kinetics of the adsorption process were further investigated. It showed that crosslinked starch phosphates can effectively remove Zn(II) from the solution.
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- Researchers mapped a glyphosate-resistant version of the enzyme EPSPS from Pseudomonas fluorescens G2 to find possible split sites using a specific experimental technique.
- They utilized a method involving intein-mediated protein complementation to successfully restore glyphosate resistance by combining fragments of the EPSPS gene.
- The study demonstrated this gene reconstitution in both E. coli and transgenic tobacco plants, showcasing its potential applications in biotechnology.
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- Soybean is a vital source of high-quality plant protein for humans, containing all essential amino acids but also includes anti-nutritional factors like lipoxygenase (Lox) and trypsin inhibitor (Ti) that can affect food quality.
- Researchers developed new soybean germplasms by selectively breeding varieties to eliminate Lox and Ti, utilizing specific gene markers for better processing and nutritional quality.
- The parent varieties used include both domestic and US introductions, aiming to enhance soybean breeding and improve production and utilization quality.
[Development of a new type soybean germplasm with null lipoxygenase isozymes].
Yi Chuan Xue Bao
February 2005
Article Synopsis
- Soybean protein is rich in balanced amino acids, including all essential ones, but has components like Lipoxygenase (Lox) and Trypsin inhibitor (Ti) that can negatively affect food quality.
- Researchers at the Institute of Crop Sciences have developed a new soybean germplasm with null Lox isozymes through biochemical marker selection, making it the first in the country to contain the null Lox1.2.3 genes.
- This advancement is expected to improve soybean breeding and enhance the quality and use of soybean products.
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- In this study, researchers used various techniques to analyze a PSTAIRE CDK-like protein in Physarum polycephalum, finding it to be 34 kD in size and located in both the nucleus and cytoplasm, predominantly associated with chromosomes and nucleoli.
- The research showed that when the cells were treated with an anti-PSTAIRE antibody, they experienced cell cycle arrest, indicating that this PSTAIRE CDK-like protein is vital for proper mitosis progression.
Article Synopsis
- A study was conducted on a Cyclin A-like protein in Physarum polycephalum to understand its location and role during the cell cycle, utilizing immunoelectron microscopy and antibody blocking methods.
- The presence of this protein was confirmed, showing a higher density in the nucleus compared to the cytoplasm, particularly peaking during the S phase of the cell cycle.
- Treatment with anti-Cyclin A antibodies disrupted the normal nuclear morphology and caused cell cycle arrests, indicating the protein's crucial role in regulating key phases of the cell cycle, especially S/G2 and G2/M transitions.