[Value of Baseline Calcitonin for Differential Diagnosis of Medullary Thyroid Cancer].

Objective: To analyze the efficacy of using baseline calcitonin (bCtn) for auxiliary diagnosis of medullary thyroid cancer (MTC) in the hypercalcitoninemic population with thyroid nodules and to explore the relationship between preoperative levels of bCtn and carcinoembryonic antigen (CEA) and MTC staging.

Methods: The clinical, pathological, imaging, and lab test data of 58 MTC patients and 84 non-MTC patients were retrospectively reviewed in the study. The patients were hospitalized at West China Hosptal, Sichuan University between 2011 and 2020.

Study on the levels of glycosylated lipoprotein in patients with coronary artery atherosclerosis.

Background: The main risk factors for atherosclerosis patients are not fully explicated. The aim of this study was to analyze the levels of blood lipid and glycosylated lipoprotein in patients with coronary artery atherosclerosis and healthy individuals and to study the relationship between the glycosylated lipoprotein and atherosclerosis.

Methods: The study involved 200 patients diagnosed with myocardial infarction caused by coronary atherosclerosis as case group and 230 healthy individuals as control group.

[Establishment of Reference Value of Hs-cTnT in Sichuan Region and Its Diagnostic Value in Patients with Chest Pain].

Objective: To establish the reference value of high sensitive cardiac troponin T (hs-cTnT) and the efficiency of reference value in the diagnosis of chest pain.

Methods: Volunteers from eight independent communities in Chengdu,Sichuan were selected with detailed records of physical examination,electrocardiogram,ultrasound examination. The level of hs-cTnT for healthy volunteers was tested to determine ninety-ninth percentile references according to sex and ages.

[Assessing Cardiac Function of Patients with Chronic Kidney Disease using N-Terminal Pro-brain Natriuretic Peptide Precursor (NT-proBNP)].

Objective: To determine the plasma level of N-terminal brain natriuretic peptide precursor (NT-proBNP) in patients with chronic kidney disease (CKD) and its association with cardiac function.

Methods: A total of 567 CKD patients admitted to the hospital from January 2013 to December 2014 were divided into six groups according to their estimated glomerular filtration rate. Their plasma level of NT-proBNP, renal function, and cardiac function were determined.

Diagnosis of Acute Myocardial Infarction in Hemodialysis Patients With High-Sensitivity Cardiac Troponin T Assay.

Context: Cardiac troponins have become the gold standard for diagnosing acute myocardial infarction (AMI) in the general population; however, their diagnostic accuracy for hemodialysis (HD) patients presenting with chest pain or dyspnea is uncertain.

Objective: To examine the diagnostic accuracy of high-sensitivity cardiac troponin T (hs-cTnT) assay for AMI in HD patients.

Design: In this prospective study, we enrolled 670 consecutive stable HD patients presenting with chest pain or dyspnea on routine predialysis therapy in the nephrology department.

High-Sensitivity Cardiac Troponin T in Patients with Acute Myocardial Infarction in Acute Exacerbation of Chronic Obstructive Pulmonary Disease.

Background: In clinical work, patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) often have high-sensitivity cardiac troponin T (hs-cTnT) levels that surpass the 99th percentile of the normal reference population, a cutoff used to screen patients for acute myocardial infarction (AMI). However, a large proportion of these patients prove not to have AMI and are frequently misdiagnosed and overtreated. We analyzed whether the cutoff value of hs-cTnT for diagnosing AMI in AECOPD patients should be adjusted.

Procalcitonin levels predict acute kidney injury and prognosis in acute pancreatitis: a prospective study.

Background: Acute kidney injury (AKI) has been proposed as a leading cause of mortality for acute pancreatitis (AP) patients admitted to the intensive care unit (ICU). This study investigated the predictive value of procalcitonin (PCT) for AKI development and relevant prognosis in patients with AP, and compared PCT's predictive power with that of other inflammation-related variables.

Methods: Between January 2011 and March 2013, we enrolled 305 cases with acute pancreatitis admitted to ICU.

[Pathogenic effects of level of nitric oxide, hyponatremia and heart function on hepatorenal syndrome].

Objective: To analyze the changes of liver function, renal function, electrolytes, heart function and serum nitric oxide (NO) in chronic severe hepatitis patients with hepatorenal syndrome (HRS) by plasma exchange (PE), study the relationship of NO, hyponatremia, heart function with HRS.

Methods: A total of 20 chronic severe hepatitis patients with HRS were recruited. All were treated thrice by PE.

[The relationship of CPS-I, OCT and hepatic encephalopathy].

Objective: To study the role of carbamyl phosphate I (CPS-I)and ornithine transcarbamoylase (OCT) levels in cirrhosis patients with and without hepatic encephalopathy, and to analyze the correlations between CPS-Iand OCT with the development of hepatic encephalopathy.

Methods: CPS-I, OCT, plasma ammonia and liver function of 95 cirrhosis patients with hepatic encephalopathy and 25 cirrhosis patients without hepatic encephalopathy in our hospital from January 2008 to December 2009 were analyzed. 60 healthy controls were recruited in the control group.

[Analysis of the relationship between hepatorenal syndrome and plasma ammonia].

Objective: To analyze the relationship between hepatorenal syndrome (HRS) and plasma ammonia.

Methods: Plasma ammonia, liver and renal function of 465 patients with liver cirrhosis in our hospital, from June 2007 to March 2009, were analyzed. 80 renal dysfunction patients and 80 healthy controls were recruited in the control group.

[Association of 7alpha-hydroxylase gene polymorphism with levels of plasma lipids].

To study the distribution of Eco31I restriction polymorphism in nucleotide -204 of 7alpha-hydroxylase gene(CYP7A1)in Sichuan Han population of China and association of the polymorphism with coronary heart disease(CHD),CYP7A1 genotyping was performed by using PCR-RFLP approach in 183 CHD patients and 101 control subjects. 7alpha-hydroxylase gene allele frequencies of C,A were 0.840 and 0.

[Study on serum oxidized low density lipoprotein and anti-oxidized competence in patient with coronary heart disease].

Objective: To analyze the serum oxidized low density lipoprotein (OX-LDL) and anti-oxidized competence in patients with coronary heart disease, and to explore the correlation between OX-LDL and atherosclerosis (AS).

Methods: The samples of fasting blood-serum were collected from 50 patients with coronary heart disease (CHD) and 50 normal controls with no cardiovascular disease, diabetes mellitus and nephrosis. The levels of triglyceride (TG), cholesterol (Chol), high density lipoprotein cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), apoproteinA1 (Apo A1), apoproteinB100 (Apo B100), lipoprotein a (Lpa), OX-LDL, lipid oxidation (LPO) and anti-oxidized competence (AOC) were detected.

[The distribution of mast cells in benign and malignant prostate lesions and its biologic significance].

Objective: To study the distribution profile of mast cells in benign and malignant prostate lesions and its biologic significance.

Methods: Fifty-three prostate specimens collected from 2000 through 2002 were examined, and the distribution of mast cells were analyzed. The paraffin sections were stained with anti-human mast cell tryptase immunohistologically.

[Association of APOA5 gene single nucleotide polymorphism with levels of lipids and coronary heart disease in Chinese].

Objective: To investigate the single nucleotide polymorphism 4 (SNP4) of the apolipoprotein A5 (APOA5) gene possible association with coronary heart disease(CHD) and its distribution of in Chinese Han population.

Methods: APOA5 SNP4 genotyping was performed using polymerase chain reaction and Hae III restriction fragment length polymorphism analysis.

Results: APOA5 allelic frequencies of T, C were 0.

[Comparing two kinds of labeled streptavidin biotin methods and selecting the best antigen retrieval method].

Objective: To compare two kinds of labeled streptavidin biotin(LsAB) methods and provide the optimal method of antigen retrieval.

Methods: The alkaline phosphatase(AP) LsAB method and the horseradish peroxidase (HRP) LsAB method were used to stain anti-tryptase in paraffin embedding tissue of patients with chronic obstructive pulmonary disease (COPD) and their staining effects were compared. The antigens were repaired by high pressure cooking, tryptin digestion and microwave, and the repairing effects were compared.

[Determining conjugated bile acids by reverse HPLC and analyzing the conjugated bile acids in sera of patients with hepatocirrhosis].

Objective: To investigate the conjugated bile acids in sera of patients with hepatocirrhosis by the determination of conjugated bile acids using reverse HPLC(high performance liquid chromatography).

Methods: Reverse HPLC was used to determine the conjugated bile acids, to evaluate the precision, accuracy, sensitivity and linear limitation of the method, and to separate and determine six conjugated bile acids in the sera of hepatocirrhotic patients. A comparison with controls was performed.