Radiosensitization effect of hsa-miR-138-2-3p on human laryngeal cancer stem cells.

Background: Treatments that target cancer stem cells play an important role in the controlling and eliminating of tumor initiation as well as in development, progression, and chemotherapy/radiotherapy resistance. In our previous study, we cultured and harvested human laryngeal cancer stem cells (CSCs) and applied microRNA biochips to screen differentially expressed miRNAs that were related to radiation tolerance in irradiated human laryngeal CSCs. According to the predicted genes and pathways of differential miRNAs target, down-regulated expression of hsa-miR-138-2-3p under radiation was thought to play a key role in enhancing the radio-sensitivity in human laryngeal squamous cancer stem cells.

[To investigate the relationship of alcohol intake and hepatocellular carcinoma among patients with hepatitis B virus infection].

Objective: To investigate the relationship of alcohol intake and hepatocellular carcinoma among patients with hepatitis B virus infection.

Methods: A total of 553 patients with HCC and 160 control subjects affected with hepatitis B virus were recruited. Serum virology, serum biochemistry, as well as demographic information were studied.