Evolutionary lability underlies drought adaptation of Australian shrubs along aridity gradients.

Leaf drought tolerance traits influence plant survival in water deficit conditions, and these traits are influenced by both the plant's evolutionary history and the environment in which the plant is currently growing. However, due to the substantial phenotypic plasticity in leaf traits, we still do not know to what degree variation in leaf traits is governed by species' phylogenetic history or by their environment. To explore this question, we re-examined a drought tolerance dataset from 37 native Australian shrub species with varying climate origins growing in a common garden located in Melbourne, Australia.

Within-crown plasticity of hydraulic properties influence branch dieback patterns of two woody plants under experimental drought conditions.

In recent year, widespread declines of Populus bolleana Lauche trees (P. bolleana, which dieback from the top down) and Haloxylon ammodendron shrubs (H. ammodendron, which dieback starting from their outer canopy) have occurred.

Novel 1,2,3-Triazole Erlotinib Derivatives as Potent IDO1 Inhibitors: Design, Drug-Target Interactions Prediction, Synthesis, Biological Evaluation, Molecular Docking and ADME Properties Studies.

Indoleamine 2,3-dioxygenase 1 (IDO1) plays a predominant role in cancer immunotherapy which catalyzes the initial and rate limiting steps of the kynurenine pathway as a key enzyme. To explore novel IDO1 inhibitors, five derivatives of erlotinib-linked 1,2,3-triazole compounds were designed by using a structure-based drug design strategy. Drug-target interactions (DTI) were predicted by DeePurpose, an easy-to-use deep learning library that contains more than 50 algorithms.

gene combined with exercise training attenuates central AngII/AT1 axis function and oxidative stress in a prehypertensive rat model.

Angiotensin-converting enzyme 2 (ACE2) or exercise training (ExT) is beneficial to hypertension, but their combined effects remain unknown. In this study, lentivirus containing enhanced green fluorescent protein (eGFP) and were microinjected into the paraventricular nucleus (PVN) of young male spontaneous hypertensive rats (SHRs), and SHRs were assigned into five groups: sedentary (SHR), SHR-ExT, SHR-eGFP, gene (SHR-ACE2), and gene combined with ExT (SHR-ACE2-ExT). Wistar-Kyoto (WKY) rats were used as a control.

[Effects of groundwater depth on functional traits of young ].

Groundwater is an important water source for phreatophytic shrubs in arid desert areas. In order to understand the impacts of groundwater depth on functional traits of phreatophytic shrubs, two groups of groundwater levels (2 and 3.5 m) were set up using lysimeter with automatic water replenishing instrument.

Climate of origin has no influence on drought adaptive traits and the drought responses of a widely distributed polymorphic shrub.

Climate has a significant influence on species distribution and the expression of functional traits in different plant species. However, it is unknown if subspecies with different climate envelopes also show differences in their expression of plant functional traits or if they respond differently to drought stress. We measured functional traits and drought responses of five subspecies of a widely distributed, cosmopolitan polymorphic shrub, Dodonaea viscosa (L.

The Synthesis and Antitumor Activity of 1,8-Naphthalimide Derivatives Linked 1,2,3-Triazole.

In this study, acenaphthylene was used as the raw material, and a series of novel 1,8-naphthalimide-1,2,3-triazole derivatives was obtained through oxidation, acylation, alkylation, and click reactions, and subsequently, their anti-tumor activities were tested. After screening, we found that Compound showed good activity against H1975 lung cancer cells, with the half maximal inhibitory concentration (IC) reaching 16.56 μM.

Population Dynamics and Life History Response to Precipitation Changes for a Desert Ephemeral Plant With Biseasonal Germination.

The changing availability of water resources and frequent extreme drought events in the context of global change will have a profound impact on desert vegetation, especially on herbaceous populations such as ephemerals. is the dominant species in the Gurbantunggut Desert. It can germinate both in spring and autumn, which is important for herbaceous layer coverage and productivity.

Discovery of Icotinib-1,2,3-Triazole Derivatives as IDO1 Inhibitors.

Tumor immunotherapy is considered to be a highlight in cancer treatment in recent years. Indoleamine 2,3-dioxygenase 1 (IDO1) is closely related to the over expression of many cancers, and is therefore a promising target for tumor immunotherapy. To search for novel IDO1-targeting therapeutic agents, 22 icotinib-linked 1,2,3-triazole derivatives were prepared and evaluated for their inhibitory activity against IDO1.

A possible link between life and death of a xeric tree in desert.

Understanding the interactions between drought and tree ontogeny or size remains an essential research priority because size-specific mortality patterns have large impacts on ecosystem structure and function, determine forest carbon storage capacity, and are sensitive to climatic change. Here we investigate a xerophytic tree species (Haloxylon ammodendron (C.A.

Apparent plasticity in functional traits determining competitive ability and spatial distribution: a case from desert.

Species competitive abilities and their distributions are closely related to functional traits such as biomass allocation patterns. When we consider how nutrient supply affects competitive abilities, quantifying the apparent and true plasticity in functional traits is important because the allometric relationships among traits are universal in plants. We propose to integrate the notion of allometry and the classical reaction norm into a composite theoretical framework that quantifies the apparent and true plasticity.

[Anatomic research on the transposition of accessory nerve to phrenic nerve].

Objective: To comprehend the anatomic characteristics and correlations between the accessory nerve and the phrenic nerve in the adult corpses.

Methods: The bilateral accessory nerves, phrenic nerves, and their branches of 20 adult corpses (38 sides) were underwent exposure. The morphologic data of the accessory nerves and the phrenic nerves above clavicle were measured.

Synthesis, cytotoxicity and protein kinase C inhibition of arylpyrrolylmaleimides.

A series of novel arylpyrrolylmaleimides was synthesized and evaluated for their in-vitro cytotoxicity against various human cancer cell lines and their protein-kinase C inhibitory activity. Some of the compounds showed high or moderate cytotoxic activity against the tested cell lines. Compound 6b is the most promising compound against the tested cancer cell lines; 6d and 6e showed moderate protein-kinase C inhibition.

Synthesis and cytotoxicity of indolopyrrolemaleimides.

A series of indolopyrrolemaleimides have been synthesized and evaluated for their cytotoxicity in vitro against human leukemia cell line and four human solid cancer cell lines. Some of the compounds showed high or mediate activity against the lines. 6dc is the most promising compound among them.