PELO facilitates PLK1-induced the ubiquitination and degradation of Smad4 and promotes the progression of prostate cancer.

PLK1 and Smad4 are two important factors in prostate cancer initiation and progression. They have been reported to play the opposite role in Pten-deleted mice, one is an oncogene, the other is a tumor suppressor. Moreover, they could reversely regulate the PI3K/AKT/mTOR pathway and the activation of MYC.

[Mechanism and progressing study in promoting wound healing with negative pressure therapy].

Negative pressure therapy (NPT) has been widely used in clinic and obtained obvious curative effects. However, its mechanism has been relatively less studied. This article updated the enhancing mechanism, physical action and biomechanics effects, etc.