Publications by authors named "Gui-Ming Hu"
Article Synopsis
- - The study explores the connection between 25-hydroxyvitamin D (25-(OH)D), vitamin B12, and cognitive frailty, using data from the National Health and Nutrition Examination Survey (NHANES).
- - Researchers found a negative correlation, showing that higher levels of 25-(OH)D are linked to a reduced risk of cognitive frailty in older adults, with a 12% risk reduction for each unit increase in vitamin D levels.
- - While the findings suggest a significant relationship between vitamin D and cognitive frailty, the authors call for more detailed longitudinal studies to confirm these results.
Coupled with the ageing population, frailty, characterized by high prevalence and difficult treatment, has progressively evolved into a significant public health concern. Frail individuals can often observe serious metabolic disorders and sleep-wake cycle disruption, which may be caused by the decline in physiological reserve and increased vulnerability. Moreover, sleep-wake cycle disruptions and metabolic dysfunctions associated with circadian rhythm disorders are considered to be a central part of the disorder.
View Article and Find Full Text PDFAims: Considering morphological heterogeneity of lung adenocarcinoma (LUAD) and no objective prognostic grading system existing currently, we aim to establish an 'optimised architecture-based grading system' (OAGS) to predict prognosis for resected LUAD.
Methods: A multicentral study involving three independent cohorts of LUAD was conducted. Predictive ability of the OAGS for recurrence-free probability (RFP) and overall survival (OS) was assessed in training cohort (n=228) by the area under the receiver operating characteristic curve (AUC), Harrell's concordance index (-index) and Kaplan-Meier survival analyses, which was validated in testing (n=135) and validation (n=226) cohorts.
Background: The role of p16INK4a as a surrogate marker for screening human papillomavirus (HPV) in esophageal squamous cell carcinoma (ESCC) remains controversial.
Methods: A comprehensive search of EMBASE, PubMed, China National Knowledge Infrastructure and China Biology Medicine was performed from inception to December 27, 2015. A random-effects model was applied to the pooled odds ratios (ORs) with 95% confidence intervals (CIs).