Publications by authors named "Gui-Lin Pi"
Article Synopsis
- This study examines how tau pathology affects episodic memory loss in Alzheimer's disease (AD), focusing specifically on ventral hippocampal CA1 (vCA1) neurons and their response to tau accumulation.
- Using various methods including proteomic analysis and social behavior tests on mice, the research identifies significant changes in excitatory and parvalbumin neurons in vCA1 associated with AD-like conditions.
- The findings suggest that activating these neurons can improve social memory impaired by tau, and that administering ursolic acid may reduce tau accumulation and restore neuron function, highlighting potential therapeutic approaches for AD-related memory loss.
