Ginsenoside Rg1 promotes non-rapid eye movement sleep via inhibition of orexin neurons of the lateral hypothalamus and corticotropin-releasing hormone neurons of the paraventricular hypothalamic nucleus.

Objective: This study investigates the sleep-modulating effects of ginsenoside Rg1 (Rg1, CHO), a key bioactive component of ginseng, and elucidates its underlying mechanisms.

Methods: C57BL/6J mice were intraperitoneally administered doses of Rg1 ranging from 12.5 to 100 mg/kg.

Profiling 32 alkaloid compounds from by UPLC-DAD-QTOF-MS/ms.

is a traditional herb medicine with alkaloids as the main bioactive substance. To identify alkaloid compounds from , its crude extract was obtained with 0.2 mol/L hydrochloric acid, and alkaloid compounds in the demineralised extract by organic solvents from crude extract were qualitatively and quantitatively analysed by UPLC-DAD-QTOF-MS/MS.

A Pair of Compound Heterozygous Variants Manifesting West Syndrome and Electrolyte Disorders in a Chinese Patient.

 Aminoacyl-tRNA synthetases (ARSs) are evolutionarily conserved enzymes that ensure the accuracy of the translation process. Isoleucyl-tRNA synthetase 2 ( ) gene is a type of ARS that encodes mitochondrial isoleucine-tRNA synthetase. Pathogenic variants in the gene are associated with mitochondrial disease which involves several patients presenting broad clinical phenotypes.

Co-delivery nanoparticles with characteristics of intracellular precision release drugs for overcoming multidrug resistance.

Combination chemotherapy in clinical practice has been generally accepted as a feasible strategy for overcoming multidrug resistance (MDR). Here, we designed and successfully prepared a co-delivery system named S-D1@L-D2 NPs, where denoted some smaller nanoparticles (NPs) carrying a drug doxorubicin (DOX) were loaded into a larger NP containing another drug (vincristine [VCR]) via water-in-oil-in-water double-emulsion solvent diffusion-evaporation method. Chitosan-alginate nanoparticles carrying DOX (CS-ALG-DOX NPs) with a smaller diameter of about 20 nm formed S-D1 NPs; vitamin E D-α-tocopheryl polyethylene glycol 1000 succinate-modified poly(lactic-co-glycolic acid) nanoparticles carrying VCR (TPGS-PLGA-VCR NPs) with a larger diameter of about 200 nm constituted L-D2 NPs.

F-fluorodeoxyglucose positron emission tomography/computed tomography findings of gastric lymphoma: Comparisons with gastric cancer.

The role of F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) in numerous malignant tumors, including gastric lymphoma, is well-established. However, there have been few studies with regard to the F-FDG PET/CT features of gastric lymphoma. The aim of the present study was to characterize the F-FDG PET/CT features of gastric lymphoma, which were compared with those of gastric cancer.

Valsartan improves the electrophysiological characteristics of left ventricular hypertrophic myocardium in spontaneously hypertensive rats.

The objective was to investigate the effects of valsartan on the electrophysiological characteristics of left ventricular hypertrophic myocardium in spontaneously hypertensive rats (SHR). A total of 24 10-week-old male SHR were divided into two groups: valsartan and non-valsartan groups (n=12 in each). Twelve 10-week-old Wistar-Kyoto rats were served as the control group.

Application of multiway-variate calibration to simultaneous voltammetric determination of three catecholamines.

Three structurally similar catecholamines, adrenaline (AA), dopamine (DA) and noradrenaline (NA), which are neurotransmitters well known for their treatment of neural disorders and many other diseases, were investigated at a glassy carbon electrode (GCE) with the use of differential pulse stripping voltammetry (DPSV). The aim was to develop a simple, rapid and cost effective method of simultaneous analysis of these three substances in typical samples such as human urine. Each analyte showed typical reversible redox behaviour with the use of cyclic voltammetry in aqueous medium in the pH range of 4.