Publications by authors named "Gui Wan"

Article Synopsis
  • Angiogenesis is crucial for healing diabetic wounds, and endothelial progenitor cell-derived extracellular vesicles (EPC-EVs) can enhance this process, but their use is limited by low yield and targeting issues.
  • The study developed biomimetic nanovesicles (EPC-NV) from EPCs and modified them with cRGD peptides (mEPC-NV) for better targeting of endothelial cells.
  • A dual hydrogel network was created that combined an acellular dermal matrix with light-cured gelatin to sustainably release mEPC-NV while providing antioxidant and antibacterial properties, making it a promising approach for diabetic wound treatment.
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Stem cells-derived extracellular vesicles (SC-EVs) have emerged as promising therapeutic agents for wound repair, recapitulating the biological effects of parent cells while mitigating immunogenic and tumorigenic risks. These EVs orchestrate wound healing processes, notably through modulating angiogenesis-a critical event in tissue revascularization and regeneration. This study provides a comprehensive overview of the multifaceted mechanisms underpinning the pro-angiogenic capacity of EVs from various stem cell sources within the wound microenvironment.

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Placental neovascularization plays a crucial role in fetomaternal circulation throughout pregnancy and is dysregulated in several pregnancy-related diseases, including preeclampsia, gestational diabetes mellitus, and fetal growth restriction. Endothelial progenitor cells (EPCs) are a heterogeneous population of cells that differentiate into mature endothelial cells, which influence vascular homeostasis, neovascularization, and endothelial repair. Since their discovery in 1997 by Asahara et al.

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Article Synopsis
  • Ischemic diseases linked to diabetes are a significant health problem, and there is growing interest in using exosomes from adipose-derived mesenchymal stem cells (ADSC-Exos) as a novel, cell-free treatment option for diabetic lower limb ischemic injuries.!* -
  • The study involved isolating ADSC-Exos and testing their effects on muscle and endothelial cells, finding that they enhance cell proliferation, migration, and vascular growth, while in-vivo tests showed improved muscle repair and blood flow recovery.!* -
  • The research identified miR-125b-5p as a key microRNA in this healing process, suggesting that it aids muscle repair by inhibiting the overexpression of ACER2
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Chronic non-healing diabetic wounds and ulcers can be fatal, lead to amputations, and remain a major challenge to medical, and health care sectors. Susceptibility to infection and impaired angiogenesis are two central reasons for the clinical consequences associated with chronic non-healing diabetic wounds. Herein, we successfully developed calcium ion (Ca) cross-linked sodium alginate (SA) hydrogels with both pro-angiogenesis and antibacterial properties.

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Diabetes is primarily characterized by hyperglycemia, and its high incidence is often very costly to patients, their families, and national economies. Unsurprisingly, the number and function of endothelial progenitor cells (EPCs) decrease in patients resulting in diabetic wound non-healing. As precursors of endothelial cells (ECs), these cells were discovered in 1997 and found to play an essential role in wound healing.

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The luminescence enhancement effect of different kinds and contents of rare earth complexe (RE(DBM)3Phen, RE = Dy, La, Gd, Sm, Y; DBM = dibenzoylmethane; Phen = 1,10-phenanthroline) sensitized Eu(DBM)3Phen doped in poly(methyl methacrylate) (PMMA) matrix was investigated using the combinatorial method. The efficiency of the luminescence enhancement increases with a decrease in the weight percentage of the Eu(DBM)3Phen and an increase in the molecular weight of the PMMA in the systems. Among these sensitization ion complexes, La(DBM)3Phen shows the highest sensitization efficiency.

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