Publications by authors named "Gui Tao Shi"
Background: Cantharidin (CTD) is the active ingredient of Chinese medicine, which has been traditionally used in multiple cancers treatment, especially in hepatocellular carcinoma (HCC). However, a comprehensive analysis of the CTD-related molecular mechanism is still necessary to understand its functions in HCC treatment. This study aimed to reveal the novel molecular targets and regulatory networks of CTD in HCC.
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- Cantharidin (CTD), derived from cantharis, shows promise in treating hepatocellular carcinoma (HCC) by targeting histone regulation and immune responses, though its target networks were previously understudied.
- *A comprehensive analysis identified 58 CTD targets involved in cancer pathways, highlighting significant changes in genes related to cell cycle and immune response, particularly affecting the EZH2 pathway.
- *In animal studies, CTD treatment increased immune cell proportions and altered the expression of immune-related genes, suggesting enhanced antitumor activity and a potential to improve immune responses in HCC.
The batch experiments of adsorption of Pb2+ onto small river sediments were conducted. The kinetics of the sorption process was analyzed. The results showed that the equilibrium time of adsorption increased with the increasing of sediment mass in solution, while both adsorbed Pb2+ on per unit of sediment and Pb2+ concentration in the solution after equilibrium decreased.
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- The study evaluated heavy metal levels in Shanghai's drinking water conservation area, finding that road dust had higher concentrations than soils and vegetables, suggesting significant contamination from human activities.
- Analysis revealed that traffic was the primary source of heavy metal pollution in road dust, with specific enrichment patterns in vegetables indicating that Cd and Zn primarily originated from soil, while other metals likely came from atmospheric pollutants.
- The ecological risk assessment indicated that heavy metals in soils posed minimal risk, while road dust and vegetables showed moderate warning levels, suggesting a need for environmental monitoring in the area.
[Characteristics of heavy metal pollution in soil and dust of urban parks in Shanghai].
Huan Jing Ke Xue
February 2007
The contents of heavy metals in soils and dust of urban parks in Shanghai were studied, and the spatial distribution of heavy metals was also analyzed. The results showed that the average contents of Pb (55.06 mg x kg(-1)), Zn(198.
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