Abnormal presentation of pregnancy and postpartum initial-onset systemic lupus erythematosus combined with diffuse alveolar hemorrhage: A case report.

Systemic lupus erythematosus (SLE) is an autoimmune disease that most commonly occurs in women of childbearing age. However, cases of SLE with abnormal pregnancy as the initial manifestation, involving the development of diffuse alveolar hemorrhage (DAH), have rarely been reported. Herein, we report the case of a young woman who underwent a cesarean section for fetal distress and growth restriction at 35 + 1 weeks' gestation.

Impact of short-term exposure to ambient air pollution on osteoarthritis: a multi-city time-series analysis in Central-Eastern China.

Osteoarthritis (OA) is a threat to public health issue with high morbidity and disability worldwide. However, unequivocal evidence on the link between air pollution and OA remains little, especially in multi-study sites. This study aimed to explore the relationship between short-term exposure to main air pollutants and the risk of OA outpatient visits in multi-study sites.

The Relationship Between Ambient Air Pollution and Hospitalizations for Gout in a Humid Subtropical Region of China.

Objective: Gout is a chronic disease caused by the deposition of sodium urate (MSU) crystals. Available data on the association between environmental hazards and gout are scarce. The present study was present to investigate the relationship between short-term exposure to air pollution and hospitalizations for acute gout from 2016 to 2020 in Anqing City, China.

Association between non-optimal temperature and hospitalizations for gout in Anqing, China: a time-series analysis.

Previous studies have found that non-optimal temperature influences the development of gout, but the results have been inconsistent. The present study aimed to explore the effects of high temperature and high temperature variation on hospitalizations for gout in Anqing, China. We collected daily data on air pollutants, meteorological factors, and hospitalizations for gout between 1January 2016 and 31 December 2020 in Anqing City, China.

Therapeutic Potential of Galectin-1 and Galectin-3 in Autoimmune Diseases.

Galectins are a highly conserved protein family that binds to β-galactosides. Different members of this family play a variety of biological functions in physiological and pathological processes such as angiogenesis, regulation of immune cell activity, and cell adhesion. Galectins are widely distributed and play a vital role both inside and outside cells.

Association of MALAT-1 gene single nucleotide polymorphisms with genetic susceptibility to systemic lupus erythematosus.

Abnormal expression and function of long non-coding RNAs (lncRNAs) are closely related to the pathogenesis of systemic lupus erythematosus (SLE). In this study, we aimed to investigate the association of lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1) gene single-nucleotide polymorphisms (SNPs) with susceptibility and clinical characteristics of SLE patients. A case-control study including 489 SLE patients and 492 healthy controls was conducted.

Impact of IL-10 gene polymorphisms and its interaction with environment on susceptibility to systemic lupus erythematosus.

This study aims to explore the impact of interleukin (IL)-10 single nucleotide polymorphisms (SNPs) and its interaction with environment on the risk of systemic lupus erythematosus (SLE). Chi-square testing method was used to investigate whether the distributions for genotype of four SNPs were differed from Hardy-Weinberg equilibrium (HWE). Logistic regression was used to test the association between IL-10 SNPs and SLE risk.

[Straw Returning Plus Nitrogen Fertilizer Affects the Soil Microbial Community and Organic Carbon Mineralization in Karst Farmland].

The use of straw returning plus nitrogen fertilizer on farmland is one of the important agronomic practices for adjusting soil organic carbon (SOC) transformations. To explore the mechanisms of straw and nitrogen fertilizer application on straw and SOC mineralization in long-term fertilized soils, an incubation experiment with the C isotope tracing technique was conducted, which involved three long-term fertilized models in typical karst soils (no fertilization, inorganic fertilization, and a combination of inorganic fertilization and straw). To study the mechanisms of C-labeled straw and SOC mineralization, four treatments were designed as follows:no straw and nitrogen (control), and straw combined with three levels of nitrogen fertilizer (0, 214.

[Effects of ellagic acid on inflammation and oxidative stress induced by AKT gene transfection in mice with fatty liver disease].

To study the effects of ellagic acid(EA)on inflammation and oxidative stress in mice with fatty liver disease induced by AKT gene transfection,the 20 female FVB mice were randomly divided into normal control group,model group and ellagic acid administration group(150,300 mg·kg~(-1)·d~(-1))(n=5).EA experimental groups and model group were using a high pressure into the tail vein transfection plasmid AKT.The next day,EA was started to administered continuously for 5 weeks after the AKT gene transfection,while the model group and the normal control group were given the same amount of saline.

[Effect of Soil Moisture and Temperature on the Soil Inorganic Carbon Release of Brown Limestone Soil in the Karst Region of Southwestern China].

In order to understand the influence of environmental factors on the carbonate conversion of the Karst soil, typical brown limestone and red soil samples were collected from the Karst ecosystem, and a 100-day incubation experiment was conducted. The characteristics of inorganic carbon release from the soil under three temperature gradients (15, 25, and 35℃) and water contents (30%, 65%, and 100% WHC) were studied by adding C-CaCO for 100 d. The results showed that under the different soil moisture and temperature conditions, the maximum rate and the cumulative amount of inorganic carbon release from the soil over 100 days varied between 0.

Diffusion characteristics of the fornix in patients with Alzheimer's disease.

White matter degradation is a major part of the pathogenesis of Alzheimer's disease (AD). The fornix is the predominant outflow tract from the hippocampus, and alterations to its microstructure in patients with AD are still being explored. Diffusion tensor imaging (DTI) is an in vivo neuroimaging technique that can provide unique information about alterations in tissue microstructure, which can indicate underlying neurobiological process at the microstructural level.

Anti-C1q antibody is a valuable biological marker for prediction of renal pathological characteristics in lupus nephritis.

The aim of this study is to investigate the association of serum anti-C1q antibody levels with renal pathological characteristics in SLE patients with lupus nephritis. Fifty-two patients with biopsy-proven lupus nephritis were enrolled. Serum anti-C1q levels (units per milliliter) were measured before renal biopsy using ELISA kit.

[Study on the chemical constituents of Leptopus chineseis].

Objective: To study the chemical constituents of the ethyl ether extract of the Leptopus chineseis.

Methods: The chemical constituents were isolated by means of chromatography and identified by spectra data and physicochemical characters.

Results: Three compounds were isolated and identified as friedelane-2alpha, 3beta-diols (1), betulinic acid (2) and 3beta-O-trans-coumaroylbetulinic acid (3).

[Age features of pure leukoaraiosis in non-demented outpatients].

Objective: To investigate the aging features of pure leukoaraiosis (LA) in non-demented outpatients.

Methods: The outpatients with age older than 40 years, without taking cholesterol lowering and B vitamin medications and with mini-mental state examination more than 24 scores were selected from July 2008 to December. 2009 in Beijing Tiantan Hospital.

Increased serum interleukin 17 in patients with systemic lupus erythematosus.

Interleukin 17 (IL-17) is a Th17 cytokine associated with inflammation, autoimmunity and defense against some bacteria, it has been implicated in many chronic autoimmune diseases including psoriasis, multiple sclerosis and systemic sclerosis. However, whether IL-17 plays a role in the pathogenesis of systemic lupus erythematosus (SLE) remains unclear. In the present study, we aimed to investigate the serum IL-17 level in patients with SLE and it's associations with disease manifestations and activity.

[Correlation between plasma level of homocysteine and cerebral large-artery atherosclerosis].

Objective: To identify whether high level of plasma homocysteine is an independent risk factor for potential cerebral large-artery atherosclerotic stenosis determined by digital subtraction angiography (DSA) in patients with ischemic stroke.

Methods: 276 adult patients with ischemic stroke experienced DSA were selected, and 224 patients with potential large-artery atherosclerotic stenosis (grade > 50%, not less than one of vascular) and 52 controls without stenosis or mild grade (grade < or = 50%) were included. Plasma homocysteine level was analyzed and conventional risk factors of cerebral stroke such as sex and age, hypertension, diabetes, long-smoking, long-alcohol and plasma levels of triglyceride, high-density lipoprotein, low-density lipoprotein was evaluated in 276 subjects.

Stenting of symptomatic M1 stenosis of middle cerebral artery: an initial experience of 40 patients.

Objective: To assess the safety and clinical efficacy of stenting for patients with symptomatic M1 stenosis of middle cerebral artery (MCA), and to assess the significance of classification based on location, morphology, and access of intracranial stenosis (LMA classification) in MCA stenting.

Methods: Forty patients with 42 symptomatic M1 stenoses refractory to medical therapy were enrolled in this study. The lesions were situated at M1 trunk (n=13), M1 origin (n=12), and M1 bifurcation (n=17), respectively, which were classified into type N (nonbifurcation lesions, n=13) and type A (prebifurcation, n=11), B (postbifurcation, n=14), C (lesion across the nonstenotic ostium of its branch, n=1), D (across the stenotic ostium of its branch, n=2), F (combinative lesions of prebifurcation and its small branch ostium, n=1) locations, morphologically into type A (n=15), B (n=23) and C (n=4) lesions, and into type I (mild-to-moderate tortuosity and smooth access, n=17), II (severe tortuosity and/or irregular arterial wall, n=18), and III (excessively severe tortuosity, n=7) accesses.

[Symptomatic intracranial artery stenosis: angiographic classifications and stent-assisted angioplasty].

Objective: To assess the safety and efficacy of stent-assisted angioplasty (SAA) for symptomatic intracranial artery stenosis, and to evaluate preliminarily the significance of classification of location, morphology and access (LMA classification) of intracranial artery stenosis in SAA.

Methods: Forty-two patients with symptomatic intracranial artery stenosis (diameter reduction: 50% - 74%, n = 15; >or= 75%, n = 27), located in middle cerebral artery (n = 27), intracranial internal carotid artery (n = 4), intracranial vertebral artery (n = 7) and basilar artery (n = 4) respectively, refractory to medical therapy were enrolled in this study.

Results: LMA classification: 23 of the forty-two lesions (54.