Publications by authors named "Gui Gang Yang"
Catechol-O-methyltransferase (COMT), an enzyme involved in the degradation and inactivation of the neurotransmitter dopamine, is associated with the sensory gating phenomenon, protecting the cerebral cortex from information overload. The COMT Val(108/158)Met polymorphism is essential for prefrontal cortex processing capacity and efficiency. The current study was designed to investigate the role of COMT Val(108/158)Met polymorphism in development, sensory gating deficit, and symptoms of schizophrenia in Han Chinese population.
View Article and Find Full Text PDFMany lines of findings support the hypothesis of the inflammation-related pathways in the multifactorial pathogenesis of schizophrenia (SZ). Interleukin-10 (IL-10), a potential anti-inflammatory cytokine, was found to be altered in chronic patients with SZ. The aim of this study was to assess the serum levels of IL-10 in first-episode and drug-naïve (FEDN) patients with SZ and its relationships with the psychopathological parameters.
View Article and Find Full Text PDFArticle Synopsis
- A two-stage genome-wide association study (GWAS) was conducted to identify susceptibility loci for schizophrenia in the Han Chinese population, involving a total of 5,675 individuals with schizophrenia and 7,202 healthy controls.
- The study identified significant loci associated with schizophrenia at chromosome regions 6p21-p22.1 and 11p11.2, with multiple genetic markers showing strong statistical significance and varying odds ratios.
- The findings suggest that genes NKAPL and ZKSCAN4, expressed in the developing mouse brain, could provide new insights into the underlying mechanisms of schizophrenia.