Disposable silicon-based all-in-one micro-qPCR for rapid on-site detection of pathogens.

Rapid screening and low-cost diagnosis play a crucial role in choosing the correct course of intervention when dealing with highly infectious pathogens. This is especially important if the disease-causing agent has no effective treatment, such as the novel coronavirus SARS-CoV-2, and shows no or similar symptoms to other common infections. Here, we report a disposable silicon-based integrated Point-of-Need transducer (TriSilix) for real-time quantitative detection of pathogen-specific sequences of nucleic acids.

Analysis of breathing via optoelectronic systems: comparison of four methods for computing breathing volumes and thoraco-abdominal motion pattern.

Breathing parameters can be measured by motion capture systems by placing photo-reflective markers on the chest wall. A computational model is mandatory to compute the breathing volume and to calculate temporal and kinematical features by the gathered markers trajectories. Despite different methods based on different geometrical approaches can be adopted to compute volumes, no information about their differences in the respiratory evaluation are available.