Publications by authors named "Guery B"
Secondary peritonitis with intra-abdominal abscesses (IAA) is difficult to treat because of the supposed low rate of penetration of antimicrobial drugs at the site of infection. However, clinical data about the actual bioavailability of antimicrobial drugs in IAA are scarce. This prospective observational study aimed at assessing the drug penetration in IAA of the antibiotics (piperacillin-tazobactam, carbapenems) and antifungals (fluconazole, echinocandins) that are usually recommended for the treatment of intra-abdominal infections.
View Article and Find Full Text PDFBackground: Fever is common in infective endocarditis (IE), yet little is known about fever duration in such patients. We aim to identify predictors of persistent fever in patients with suspected IE.
Methods: This study was conducted at the Lausanne University Hospital, Switzerland, from January 2014 to June 2023.
Objectives: Duration of treatment for uncomplicated streptococcal bacteraemia is unknown. The study aims to assess clinical outcomes of patients with uncomplicated streptococcal bacteraemia receiving a short course (5-10 days) of antimicrobial treatment compared to those receiving the traditional, longer duration (11-18 days).
Methods: This retrospective study was conducted at the Lausanne University Hospital, Switzerland and included episodes of uncomplicated streptococcal bacteraemia among adult patients from 2015 to 2023.
Infective Endocarditis (IE) is a complex, life-threatening disease. The aim of the present study was to evaluate the impact of the Endocarditis-Team on management of IE. This observational study conducted at a university hospital (2015‒22), included adult patients with IE.
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- A study involving 302 cases of prosthetic valve endocarditis (PVE) showed a one-year mortality rate of 31%.
- Early-onset PVE (within 6 months of valve surgery) did not result in worse outcomes compared to late-onset PVE, with mortality rates of 21% versus 32% (p=0.126).
- Both early and late-onset categories required similar rates of redo valve surgeries.
Article Synopsis
- Diagnosing infective endocarditis (IE) is complex, and this study compared the effectiveness of the 2015 and 2023 Duke clinical criteria for diagnosing the condition.
- Conducted in two Swiss University Hospitals, researchers analyzed data from 3127 patients suspected of having IE, with 1177 confirmed cases, to assess the agreement between the clinical criteria and expert diagnoses.
- Results showed that the 2023 criteria had a higher sensitivity (69%) compared to the 2015 criteria (59%), although both versions categorized about one-third of episodes as possible IE.
Purpose: To determine predictors of mortality among patients with Pseudomonas aeruginosa bacteraemia.
Methods: Retrospective study.
Setting: This study conducted at the Lausanne University Hospital, Switzerland included adult patients with P.
Background: Streptococci are a common cause of infective endocarditis (IE). We aimed to evaluate the performance of the HANDOC score to identify patients at high risk for IE and the Duke clinical criteria of the European Society of Cardiology (ESC; 2015 and 2023 versions) and the 2023 version from the International Society of Cardiovascular Infectious Diseases (ISCVID) in diagnosing IE among patients with streptococcal bacteremia.
Methods: This retrospective study included adult patients with streptococcal bacteremia hospitalized at Lausanne University Hospital.
Objectives: To ascertain whether infective endocarditis (IE) was associated with persistent bacteraemia/candidaemia among patients with suspected IE.
Methods: This study included bacteraemic/candidaemic adult patients with echocardiography and follow-up blood cultures. Persistent bacteraemia/candidaemia was defined as continued positive blood cultures with the same microorganism for 48 h or more after antibiotic treatment initiation.
Background: Streptococcal bacteremia is associated with high mortality. Thia study aims to identify predictors of mortality among patients with streptococcal bacteremia.
Methods: This retrospective study was conducted at the Lausanne University Hospital, Switzerland, and included episodes of streptococcal bacteremia among adult patients from 2015 to 2023.
Article Synopsis
- This observational study conducted at Lausanne University Hospital from 2014 to 2023 aimed to evaluate the occurrence of infective endocarditis (IE) in patients with bone and joint infections (BJIs) and bacteraemia.
- Out of 384 episodes analyzed, 75% involved native BJI and 29% involved orthopedic implant-associated infection (OIAI), with some patients having both types.
- The study found a prevalence of IE at 27%, specifically 31% in patients with NBJI compared to only 13% in patients with OIAI, highlighting a significant difference between the two groups.
Patients admitted to the intensive care unit (ICU) often experience endotoxemia, nosocomial infections and sepsis. Polymorphonuclear and monocytic myeloid-derived suppressor cells (PMN-MDSCs and M-MDSCs) can have an important impact on the development of infectious diseases, but little is known about their potential predictive value in critically ill patients. Here, we used unsupervised flow cytometry analyses to quantify MDSC-like cells in healthy subjects challenged with endotoxin and in critically ill patients admitted to intensive care units and at risk of developing infections.
View Article and Find Full Text PDFClostridioides difficile is a leading cause of healthcare-associated infections. The main objective was to assess the current landscape of CDI infection prevention and control (IPC) practices. An anonymous survey of IPC practices for CDI was conducted between July 25 and October 31, 2022.
View Article and Find Full Text PDFIn this retrospective/prospective study, we assessed the role of fundoscopy in 711 episodes with suspected infective endocarditis (IE); 238 (33%) had IE. Ocular embolic events (retinal emboli or chorioretinitis/endophthalmitis) and Roth spots were found in 37 (5%) and 34 (5%) episodes, respectively, but had no impact on IE diagnosis.
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- The study assessed the diagnostic effectiveness of the Duke-ISCVID 2023 criteria for infective endocarditis (IE) against earlier versions from 2000 and 2015.
- Conducted at two university hospitals between 2014 and 2022, it involved 2132 patients, 1101 of whom were confirmed to have IE.
- Results showed the new criteria improved sensitivity to 84% (up from 70%) but decreased specificity to 60% (down from 74%), suggesting a need for further refinements to balance these diagnostic metrics.
Article Synopsis
- The Duke criteria for diagnosing infective endocarditis were updated in 2023, and this study evaluates their diagnostic accuracy, particularly for patients with Staphylococcus aureus bacteremia (SAB).
- Analyzing data from 1344 SAB episodes, the revised 2023 criteria showed improved sensitivity (81% for Duke-ISCVID and 82% for Duke-ESC) compared to the 2015 version (75%), although specificity decreased from 99% to 96%.
- The study highlights that while spondylodiscitis was more common in patients with SAIE, this trend was not significant when certain criteria were excluded, indicating the need for further research on the new criteria's components.
Background: Faecal microbiota transplantation (FMT) is the standard treatment for patients with multiple recurrent Clostridioides difficile infection (rCDI). Recently, new commercially developed human microbiota-derived medicinal products have been evaluated and Food and Drug Administration-approved with considerable differences in terms of composition, administration, and targeted populations.
Objectives: To review available data on the different microbiota-derived treatments at the stage of advanced clinical evaluation and research in rCDI in comparison with FMT.
Core genome multilocus sequence typing of Clostridioides difficile to investigate transmission in the hospital setting.
Eur J Clin Microbiol Infect Dis
December 2023
Purpose: Traditional epidemiological investigations of healthcare-associated Clostridioides difficile infection (HA-CDI) are often insufficient. This study aimed to evaluate a procedure that includes secondary isolation and genomic typing of single toxigenic colonies using core genome multilocus sequence typing (cgMLST) for the investigation of C. difficile transmission.
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- SARS-CoV-2 can affect the gut microbiota and immune responses, leading to varying gastrointestinal symptoms in COVID-19 patients.
- A study included 57 COVID-19 patients and 19 non-COVID-19 ICU patients to analyze changes in gut microbiota through rectal swab samples taken over time.
- Results showed decreased microbiota diversity in COVID-19 patients, with notable differences in bacterial composition compared to non-COVID-19 patients, including increased Bacteroides and decreased butyrate-producing bacteria in ICU patients.
Purpose: Embolic events (EEs) are a common complication of left-side infective endocarditis (IE). The aim of the present study was to identify risk factors for the occurrence of EEs before or after antibiotic treatment instauration among patients with definite or possible IE.
Methods: This retro-prospective study was conducted at the Lausanne University Hospital, Lausanne, Switzerland, from January 2014 to June 2022.