Clinical utility of ultrasonography, pulse oximetry and arterial line derived hemodynamic parameters for predicting post-induction hypotension in patients undergoing elective craniotomy for excision of brain tumors - A prospective observational study.

Background: Hypotension, which is a common adverse effect of induction of anesthesia, may be especially detrimental in neurosurgical patients. Hence, it is important to investigate hemodynamic parameters which may be useful in identifying patients at risk of hypotension, following induction. Our study was designed to assess the utility of parameters derived from ultrasonography, pulse oximeter and arterial line for predicting post-induction hypotension.

Patients' knowledge about medicines improves when provided with written compared to verbal information in their native language.

Background: Patient's knowledge on the medicines prescribed is vital in reducing medication errors and improving adherence and patient satisfaction. This study assessed the patients' knowledge on medicines prescribed and compared improvement following verbal or written information given in patients own language.

Methods: Seventy-five trainee pharmacists randomised to verbal or written groups, provided information to consecutive consenting patients attending medical and surgical clinics in the outpatient department of National Hospital of Sri Lanka.

Anterior cruciate ligament rupture and associated Segond fracture: Incidence and effect on associated ligamentous and meniscal injuries.

Introduction: The Segond fracture is an avulsion fracture of the lateral tibial plateau and is widely considered to be pathognomonic of anterior cruciate ligament (ACL) rupture. In addition to ACL rupture, Segond fractures have also been noted to be associated with significant intra-articular pathology such as meniscal injuries as well as extra-articular pathology such as collateral ligament injuries. This is likely due to the fact that the presence of a Segond fracture may represent increased rotatory instability.

Orphan Medical Devices and Pediatric Cardiology - What Interventionists in Europe Need to Know, and What Needs to be Done.

Medical devices include a great diversity of technologies, which are evaluated and approved in the European Union (EU) according to a revised law that came into effect on 26 May 2021, known as the Medical Device Regulation or MDR (EU 745/2017). It has a transition period that allows products that were approved under the previous rules (the EU Medical Device Directives) to continue to be marketed until 26 May 2024 at the latest. As a result of a series of unforeseen factors, there is a possibility that the MDR may result in products becoming unavailable, with the consequent risk of a loss of some interventions that are reliant upon those devices.

Is Electrocardiogram Helpful in Predicting a Rise in Troponin I as a Marker of Anthracycline Cardiotoxicity?

Objective: Screening patients on anthracycline-based chemotherapy regimens for the development of cardiotoxicity can be resource intensive. We therefore studied various traditional electrocardiogram (ECG) parameters to correlate and possibly predict the development of elevated Troponin I as a surrogate marker of anthracycline-induced cardiotoxicity.

Materials And Methods: This was a single-centre prospective cohort study done between January 2014 to January 2016.

Small extracellular vesicles as a multicomponent biomarker platform in urinary tract carcinomas.

Extracellular vesicles are a large group of nano-sized vesicles released by all cells. The variety of possible cargo (mRNAs, miRNAs, lncRNAs, proteins, and lipids) and the presence of surface proteins, signaling molecules, and receptor ligands make them a rich source of biomarkers for malignancy diagnosis. One of the groups gathering the most interest in cancer diagnostic applications is small extracellular vesicles (sEVs), with ≤200 nm diameter, mainly composed of exosomes.

Detection of iron-bearing mineral assemblages in Nainarmalai granulite region, south India, based on satellite image processing and geochemical anomalies.

Although India's large iron ore reserves are well known, there are still few studies and research on iron ore prospecting in smaller deposits or the deposits with lower grade. Remote sensing concepts are useful to target for mineral exploration, since it covers a large area at low cost. In this research spectral remote sensing and digital image processing of ASTER data to locate and delineate the regions with iron oxide-bearing soils in granulite terrain at Nainnarmalai (southern India) that has hypothetical reserve 8.

Clinical spectrum and neuroimaging findings in children with seizures: A five-year retrospective study.

Objectives: Seizures are the most common neurological illness in the pediatric population and account for 1% of all emergency department (ED) visits and 2% of all visits to children's hospital EDs. Pediatric epilepsy presents with various diagnostic challenges. Neuroimaging, especially structural neuroimaging and preferably MRI brain, plays an essential role in diagnosing, managing, and guiding pediatric epilepsy treatmentThe study aimed to estimate the clinical spectrum of seizures in children and examine the neuroimaging findings in children with seizures

Materials & Methods: The study was a hospital-based retrospective observational study.

Dysphagia Lusoria: A Rare Cause of Adult Dysphagia.

Dysphagia lusoria is an unusual condition characterized by difficulty swallowing secondary to compression of the esophagus by the aberrant right subclavian artery (ARSA). It occurs due to embryologic anomalies of the brachial arches, which are often unrecognized. Dysphagia is the prime presenting symptom in the majority, in addition to the other tracheoesophageal symptoms.

Multicomponent Synthesis of Spiro-dihydropyridine Oxindoles Cascade Spiro-cyclization of Knoevenagel/Aza-Michael Adducts.

An efficient, straightforward, and one-pot synthesis of biologically relevant spiro-dihydropyridine oxindoles was described readily available isatin, malononitrile, allenoate, and amines. The metal/organocatalyst-free, EtN-mediated reaction proceeds cascade spiro-cyclization of generated Knoevenagel/aza-Michael adducts. The reaction has great flexibility over electron-rich and electron-poor substituents affording desired products in good to excellent yields.

Modern Synthesis and Sintering Techniques of Calcium Copper Titanium Oxide (CaCuTiO) Ceramics and Its Current Trend in Prospective Applications: A Mini-Review.

Calcium Copper Titanium Oxide (CaCuTiOCCTO) has grasped massive attention for its colossal dielectric constant in high operating frequencies and wide temperature range. However, the synthesis and processing of CCTO directly influence the material's properties, imparting the overall performance. Researchers have extensively probed into these downsides, but the need for a new and novel approach has been in high demand.

Lucid dreaming increased during the COVID-19 pandemic: An online survey.

The COVID-19 pandemic changed people's lives all over the world. While anxiety and stress decreased sleep quality for most people, an increase in total sleep time was also observed in certain cohorts. Dream recall frequency also increased, especially for nightmares.

Multipronged Phenotyping Approaches to Characterize Sugarcane Root Systems.

Roots are the primary conductors of water and nutrients and play a vital role in sustaining growth and yield under stressful environments. The study of plant roots poses methodological difficulties in in situ assessment and sampling, which is especially true for sugarcane (Saccharum spp.).

Environmental Emission Validation Analysis Using a Dual-Fuel Engine.

The research work presents the results of testing using an internal combustion engine ignition/compression using diesel and LPG mixtures without preheating. The energy performance of regulated brake emissions and changes in fuel consumption for a compression ignition engine is investigated in this study. It is assured that the engine's operation is not harmed as a result of the installation of this mix.

Mismatch Repair Screening of Gastrointestinal Cancers: The Impact on Lynch Syndrome Detection and Immunotherapy.

Introduction: Mismatch repair immunohistochemistry (MMR IHC) or microsatellite instability (MSI) testing is now routinely performed in patients with colorectal cancer (CRC) to select those requiring Lynch syndrome testing. MMR IHC is also carried out on CRC and upper gastrointestinal (GI) cancers to select patients for immunotherapy. We review the Royal Marsden Hospital's pathway of molecular to germline testing for Lynch syndrome in the context of NICE guidance and the National Test Directory.

Vanillic acid attenuates cell proliferation, xenobiotic enzyme activity, and the status of pulmonary mitochondrial enzymes in lung carcinoma.

The purpose of the study is to determine the anti-proliferative and mitochondrial status of benzo(a)pyrene-induced lung cancer in Swiss albino mice, as well as the modulatory effect of vanillic acid on it. B(a)P had altered levels of lysosomal enzymes, xenobiotic-metabolizing enzymes, cell proliferation, inflammation, and mitochondrial abnormalities, whereas treatment with VA treatment significantly reversed the aforementioned activities. According to the findings, VA greatly reduces lung carcinogenesis by restoring antioxidants and xenobiotic-enzyme levels, consequently proving to be an anti-proliferative and anti-inflammatory drug against lung cancer in mice.

Hyperspectral Image Classification Model Using Squeeze and Excitation Network with Deep Learning.

In the domain of remote sensing, the classification of hyperspectral image (HSI) has become a popular topic. In general, the complicated features of hyperspectral data cause the precise classification difficult for standard machine learning approaches. Deep learning-based HSI classification has lately received a lot of interest in the field of remote sensing and has shown promising results.

A stitch in time saves nine: timely use of N-acetyl cysteine (NAC) for chemotherapy-induced veno-occlusive disease (VOD)-is it a cost-effective alternative?

Chemotherapy-induced veno-occlusive disease (VOD) is a rare liver dysfunction seen among pediatric cancer patients which could lead to severe morbidity and mortality. Defibrotide is the commonly used antidote in the management of both stem cell transplant and chemotherapy-associated VOD along with liver supportive measures. Defibrotide is costly and generally not accessible to majority of patients treated at resource poor settings.

Cross-sectional associations of physical frailty with fall, multiple falls and fall-injury among older Indian adults: Findings from LASI, 2018.

Background: Although there has been a range of studies that focused on physical frailty and associated fall outcomes within developed countries, similar studies from developing countries have been limited. This study aimed to examine the relationship between physical frailty and the prevalence of falls, multiple falls and fall-related injuries among the ageing population within the Indian context.

Methods: Individual-level data from the first wave of the Longitudinal Aging Study in India (LASI) with 28,285 older adults aged 60 years and above (male 48.

Role of dynamic and parametric whole-body FDG PET/CT imaging in molecular characterization of primary breast cancer: a single institution experience.

Aim: The aim of this pilot study was to assess the role of dynamic whole-body PET and parametric imaging in the biological characterization of primary breast cancer.

Materials And Method: In total 24 histologically proven primary breast cancer lesions in 21 consecutive patients were retrospectively analyzed. Each patient underwent 18F-fluoro-deoxyglucose whole-body dynamic PET-CT before any treatment.

Self-healing cutaneous nodules with fever and arthritis: worrisome presentation of a benign disorder.

A 4-year-old boy with extensive papules and nodules with arthritis was evaluated and followed up. In spite of the initial worrisome presentation, the lesions showed near-complete resolution over a 2-year follow-up period. Click here for the corresponding questions to this CME article.

Module intervention to improve involvement and practices of fathers towards infant and young child feeding (IYCF) in Coastal South India - a randomized controlled trial.

Overall child health depends on nutrition and its related practices. At the family level, responsibility of child feeding lies with both parents. There is no uniform and systematic way to determine and assess the practices of fathers in infant and young child feeding (IYCF).

Identification of Novel Serum Proteins Associated with Myelination and Cholesterol Transport in Neuromyelitis Optica Spectrum Disorders by Mass Spectrometry.

Unlabelled: Neuromyelitis optica spectrum disorders (NMOSD) is a demyelinating autoimmune disease affecting the central nervous system causing inflammatory lesions in the optic nerves, spinal cord and other vital areas of CNS. The clinical manifestations include acute transverse myelitis with paraplegia and optic neuritis with impaired vision. In the present study we focussed on comparative expression of serum proteins between NMOSD variants and control.