Publications by authors named "Guermarie Velazquez"
Channels (Austin)
October 2010
Article Synopsis
- Cholesterol impacts the biophysical properties of cell membranes and the function of membrane proteins, highlighting the need to understand how lipid composition regulates membrane receptors.
- The nicotinic acetylcholine receptor (nAChR) is a useful model for studying this, as only a small portion of it is activatable.
- Research shows that cholesterol depletion increases the current of a mutant nAChR (alpha C418W) by moving these receptors from a non-activatable state in caveolin-1-positive domains to an activatable pool, indicating a novel way to regulate cholinergic signaling in the nervous system.
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