Publications by authors named "Guerkan Kaya"
IL-17E (IL-25) is a member of the IL-17 cytokine family involved in the promotion of type 2 immune responses. Recently, IL-17E has been reported to be up-regulated in distinct skin inflammatory diseases such as psoriasis and atopic and contact dermatitis. We assessed the role played by IL-17E in skin inflammation.
View Article and Find Full Text PDFWe have previously shown that cytochrome P450 1A1 (CYP1A1) was highly induced for a long period of time in a patient who had been poisoned by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a compound known to activate the aryl hydrocarbon receptor (AhR). During that period of time, no sebaceous glands could be observed in the skin of this patient. In this study, starting from observations in the patient exposed to TCDD, we analyzed the seboatrophy induced by dioxins in mice.
View Article and Find Full Text PDFArticle Synopsis
- Many people are exposed to dangerous chemicals called dioxins, mostly from the food they eat.
- A man in a study was exposed to a super high amount of dioxin, leading to severe skin problems that covered a large part of his body.
- Researchers found that his skin reacted in special ways, which could help them understand how to find new signs of dioxin exposure in other people.