Tau PET quantitation methods have been used in research settings and clinical trials to measure tau burden for diagnostic, staging, and prognostic purposes. However, these methods require specialized software, skilled analysts, and advanced image processing. We developed a novel F-flortaucipir PET (FTP, or Tauvid) visual read method enabling stratification of patients with Alzheimer disease (AD) according to the tau level without the need for quantitation.
View Article and Find Full Text PDFMedicinal plants and natural compounds have been considered alternative therapeutic options for counteracting postmenopausal disorders thanks to their different concomitant effects, including antioxidant and anti-inflammatory properties and the regulation of hormone activity. It is important to highlight that the efficacy of medicinal plants and natural compounds increases when used in combination, thus making the development of herbal formulations rational. Therefore, the present study aimed to evaluate the phytochemical and pharmacological properties of an innovative formulation consisting of resveratrol and water extracts from , , , and .
View Article and Find Full Text PDF, a common protist in the human gastrointestinal tract, exhibits substantial genetic diversity and has been linked to varying clinical outcomes. However, its role in human health remains debated, with studies suggesting both commensal and pathogenic interactions. This scoping review aims to systematically map the existing evidence on the association between presence and human clinical outcomes.
View Article and Find Full Text PDFImmune checkpoint inhibitors (ICIs) therapy has revolutionized cancer treatment. However, it is important to acknowledge that ICI therapy can lead to immune-related adverse events (irAEs), including myocarditis. While early-onset myocarditis is well-documented, late-onset cases are increasingly recognized.
View Article and Find Full Text PDFWhile the stramenopile , first discovered in 1911, is considered the most prevalent enteric protist in humans, its biology remains largely unexplored. Clinical studies have only recently begun investigating the role of in the gut and its relationship with the gut microbiome, and whether it plays a pathogenic role in human and animal health. Aiming to gather leading researchers in the field to encourage and stimulate cross-disciplinary dialogue while fostering long-term international collaborations, the Fourth International Conference was hosted from the 17 to the 19 of September 2024 in Heraklion (Crete, Greece).
View Article and Find Full Text PDFToday's awareness of environmental pollution and the idea of creating a reuse area for waste is one of the trend topics. The base opinion, regarding the reuse of any material is that all resources are inherently limited in the world. In the ethical approach, it is a moral issue that people take responsibility for future generations to protect nature.
View Article and Find Full Text PDFObjective: Negative bias towards patients with mental illness contributes to worsened healthcare outcomes. However, few data exist on interventions to decrease bias. In this study, the authors examined the impact of brief patient exposure on first-year medical student perceptions of psychiatry.
View Article and Find Full Text PDFBackground: Reconstruction of composite digital defects presents challenges, as it requires short-pedicled, small flap. In this report, the authors present a new vascularized bone graft based on the inferior medial genicular artery (IMGA) harvested from the proximal medial tibia with overlying skin. The purpose of this study was to investigate the feasibility of this new flap for small composite tissue defects in digits.
View Article and Find Full Text PDFİnsanlığın karşı karşıya kaldığı en önemli halk sağlığı sorunlarından biri olan ilaç direnci, antilayşmanyal ajan geliştirmede yeni stratejileri ve yaklaşımları zorunlu kılmaktadır. Dışa atım pompa inhibitörleri (DAPİ) ve diğer aday ajanlar ile ilgili gelişmeler umut verici olmakla birlikte, mevcut antilayşmanyallerin kullanım sürelerini ve etkinliklerini artırabilme arayışları da devam etmektedir. Bu çalışmada rezerpin (REZ), berberin (BER) ve verapamil (VER) olmak üzere üç adet DAPİ'nin antilayşmanyallere etkisinin araştırılması amaçlanmıştır.
View Article and Find Full Text PDFCognitive resilience (CR) describes the phenomenon of individuals evading cognitive decline despite prominent Alzheimer's disease neuropathology. Operationalization and measurement of this latent construct is non-trivial as it cannot be directly observed. The residual approach has been widely applied to estimate CR, where the degree of resilience is estimated through a linear model's residuals.
View Article and Find Full Text PDFObjective: This study utilized three cell lines: normal prostate epithelial RWPE-1, androgen-dependent LNCaP, and androgen-independent PC3. We investigated the inhibitory effects of phenylboronic acid (PBA)'s inhibitory effect on cellular proliferation due to its ability to disrupt microtubule formation in prostate cancer cell lines. Additionally, this study aimed to assess the cytotoxic effects of PBA on prostate cancer cells using twodimensional (2D) and three-dimensional (3D) cell culture models.
View Article and Find Full Text PDFClin Microbiol Infect
January 2025
Background: Incorporating ethics into clinical practice guidelines (CPGs) can be challenging. This is particularly evident for infectious diseases (ID) CPGs because of the complexity of ID ethics (IDE) and the multiplicity of populations at risk for infections.
Objectives: The OPENING project (IncOrPorating Ethics iN ClINical Guidelines: Practical Indications) was initiated by the European Society of Clinical Microbiology and Infectious Diseases Ethics Advisory Committee in collaboration with the European Society of Clinical Microbiology and Infectious Diseases Guidelines Subcommittee to generate guidelines for the systematic inclusion of ethics principles into ID CPGs.
J Mater Sci Mater Med
November 2024
The quality of platelet-rich fibrin (PRF) is contingent on the surface characteristics interfacing with blood. Titanium's superior platelet activation, surpassing silica, has made Titanium-platelet-rich fibrin (T-PRF) a favored autogenous bone graft material due to its extended degradation time. Pioneering a novel approach, this study aims to achieve an enhanced fibrin structure using glass tubes coated with nano-titanium, marking the surface's debut in our PRF production endeavors.
View Article and Find Full Text PDFRestless legs syndrome is usually associated with periodic limb movements during sleep, which are defined as repetitive, stereotyped movements in sleep. Changes in spectral analysis of electroencephalography and heart rate were shown to be associated with periodic limb movements during sleep and non-periodic leg movements in sleep. Considering the circadian distribution of symptoms of restless legs syndrome, we investigated spectral electroencephalography and heart rate accompanying periodic limb movements, isolated leg movements and short-interval leg movements during suggested immobilization test.
View Article and Find Full Text PDFClin Implant Dent Relat Res
December 2024
Statement Of Problem: Osseointegration is now primarily established, but soft tissue integration is still susceptible to failure and problematic on implant surfaces. So, implant dentistry is increasingly focusing on improving peri-implant soft tissue integration.
Purpose: The present study aimed to evaluate the blood fibrin clot formation and adhesion on the abutment after cleaning and decontamination and determine the suitable abutment surface associated with fibrin clot attachment.
Gastrointestinal stromal tumors (GISTs), the most common mesenchymal tumors in the gastrointestinal tract, are increasingly treated with minimally invasive surgeries. Developed techniques include laparoscopic, endoscopic, and hybrid methods for gastric GIST resection. Our study, focusing on single-incision laparoscopic intragastric resection for gastric GISTs, aims to evaluate its safety, efficacy, and long-term outcomes.
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