Bioactive Compounds and Antimicrobial Activities in Iranian Ecotypes for Potential Food and Medicinal Uses.

The genus , belonging to the Rosaceae family, exhibits widespread distribution across Iran, comprising 17 species. Hawthorn has garnered significant attention in recent years as a prominent herbal remedy in phytotherapy and culinary applications. Various plant parts, including flowers, leaves, and fruits, have been traditionally employed to address cardiovascular conditions such as hypertension, hypotension, palpitations, and cardiac arrhythmias.

Determination of paclobutrazol using square wave voltammetry based on a molecularly imprinted polymer and boron-doped copper oxide/graphene nanocomposite.

In the present study, a novel voltammetric sensor based on a boron-doped copper oxide/graphene (B-CuO-Gr) nanocomposite and molecularly imprinted polymer (MIP) was developed for the detection of paclobutrazol (PAC) in apple and orange juice samples. The B-CuO-Gr nanocomposite was prepared using sol-gel and calcination methods. After modifying glassy carbon electrodes with the B-CuO-Gr nanocomposite, PAC-imprinted electrodes were prepared in the presence of 100.

Comparing the clinical efficacy of preganglionic and preganglionic plus ganglionic transforaminal epidural steroid injections for lumbosacral radicular pain.

Objectives: To compare the effectiveness of preganglionic transforaminal epidural steroid injection (TFESI) with preganglionic plus postganglionic TFESI.

Methods: Patients with unilateral radicular pain and disc pathology were randomly assigned to either the preganglionic group or the preganglionic plus postganglionic group. All patients were evaluated using a numeric rating scale (NRS) and a patient satisfaction scale (PSS) at the third week and the third month after treatment.

Machine Learning-Based Prediction of Prostate Biopsy Necessity Using PSA, MRI, and Hematologic Parameters.

To establish a machine learning (ML) model for predicting prostate biopsy outcomes using prostate-specific antigen (PSA) values, multiparametric magnetic resonance imaging (mpMRI) findings, and hematologic parameters. The medical records of the patients who had undergone a prostate biopsy were evaluated. Laboratory findings, mpMRI findings, and prostate biopsy results were collected.

Risk Assessment for Preeclampsia in the Preconception Period Based on Maternal Clinical History via Machine Learning Methods.

: This study was aimed to identify the most effective machine learning (ML) algorithm for predicting preeclampsia based on sociodemographic and obstetric factors during the preconception period. : Data from pregnant women admitted to the obstetric clinic during their first trimester were analyzed, focusing on maternal age, body mass index (BMI), smoking status, history of diabetes mellitus, gestational diabetes mellitus, and mean arterial pressure. The women were grouped by whether they had a preeclampsia diagnosis and by whether they had one or two live births.

Does Radioactive Iodine Treatment Affect Thyroid Size and Tracheal Diameter?

There exist three principal treatment modalities employed in the management of hyperthyroidism attributable to excessive hormone secretion by the thyroid gland: antithyroid pharmacotherapy, surgical intervention, and radioactive iodine (RAI) therapy. Surgical intervention is typically indicated for markedly enlarged thyroid glands that exert pressure on the trachea. The objective of this investigation was to ascertain the influence of RAI on thyroid volume and tracheal diameter.

Unlocking Excellence: Improving Nursing Students' Knowledge of Pressure Injury Prevention through an Escape Room Experience.

Objective: To determine if an escape room game approach, which has emerged as a novel and engaging education tool, is an effective method to improve nursing students' knowledge of pressure injury (PI) prevention and attitudes toward the care of patients with a PI.

Methods: This study evaluated 33 university nursing students using a quasi-experimental pretest/posttest design. Students completed five questionnaires before the escape room experience and again 1 month after.

Predicting Live Weight for Female Rabbits of Meat Crosses From Body Measurements Using LightGBM, XGBoost and Support Vector Machine Algorithms.

Prediction of body weight (BW) using biometric measurements is an important tool especially for animal welfare and automatic phenotyping tools that needs mathematical models. In this study, it was aimed to predict the BW using body length (BL), chest girth (CG) and width of the waist (WW) for rabbits of the maternal form of Hyla NG. The standard rabbit-raising practices were applied for the animals.

Assessing Internalized Beliefs: Psychometric Evidences for the Pathogenic Belief Scale in Turkish Culture.

This study was conducted to test the reliability and validity of the Pathogenic Belief Scale (PBS) on adult individuals. Participants consisted of 299 adults, including 189 (63.2%) females and 110 (36.

Let-7b-5p sensitizes breast cancer cells to doxorubicin through Aurora Kinase B.

MicroRNAs (miRNAs) are small, non-coding RNAs that regulate the expression level of the target genes in the cell. Breast cancer is responsible for the majority of cancer-related deaths among women globally. It has been proven that deregulated miRNAs may play an essential role in the progression of breast cancer.

Trends in prescribing montelukast in patients with asthma in real-life: Results from the Turkish adult asthma registry.

Montelukast, a leukotriene receptor antagonist (LTRA) approved for the treatment of asthma and allergic rhinitis, is widely used, though real-world data on its application in asthma management remain limited. This registry-based study evaluated the use of montelukast in adult asthma patients, examining demographic and disease characteristics, asthma control status, asthma phenotypes, presence of atopy, and treatment regimens. Among 2053 patients analyzed, 61.

Comprehensive Approach for Sequential MALDI-MSI Analysis of Lipids, -Glycans, and Peptides in Fresh-Frozen Rodent Brain Tissues.

Multiomics analysis of single tissue sections using matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) provides comprehensive molecular insights. However, optimizing tissue sample preparation for MALDI-MSI to achieve high sensitivity and reproducibility for various biomolecules, such as lipids, -glycans, and tryptic peptides, presents a significant challenge. This study introduces a robust and reproducible protocol for the comprehensive sequential analysis of the latter molecules using MALDI-MSI in fresh-frozen rodent brain tissue samples.

Unveiling Risk Profiles: A Latent Profile Analysis of 21st-Century Skills, Resistance to Change, and Cognitive Flexibility.

Objectives: Limited research utilized a person-centered approach in examining 21st-century skills. This study used latent profile analysis to explore the relationships between resistance to change, cognitive flexibility, and 21st-century skills, including creativity, cooperativity, critical thinking, communication, and problem-solving.

Materials And Methods: A convenience sampling approach was used to recruit 502 individuals (342 females; mean = 21.

Validation of biomarkers and clinical scores for the detection of uterine leiomyosarcoma: a case-control study with an update of pLMS.

Background: The diagnosis of rare uterine leiomyosarcoma (uLMS) remains a challenge given the high incidence rates of benign uterine tumors such as leiomyoma (LM). In the last decade, several clinical scores and blood serum markers have been proposed. The aim of this study is to validate and update the pLMS clinical scoring system, evaluating the accuracy of the scoring system by Zhang et al.

Infections among adults hospitalized in intensive care after the 2023 earthquake in the southeastern part of Türkiye: a multi-center observational study.

Background: Scarce evidence is available on the epidemiology of microbiologically proven clinical infections in patients admitted to the intensive care unit (ICU) after a great earthquake. The main aim of this study was to assess clinical infections and microbiological features in patients admitted to the ICU following the 2023 earthquake in the southeastern region of Türkiye with a focus on the timing of culture positivity during their ICU stay. The secondary objectives included determining antibiotic susceptibility patterns, identifying the types of antibiotics administered upon ICU admission, evaluating the appropriateness of antibiotic usage, assessing patient outcomes, and identifying factors that influence microbiologically confirmed clinical infections.

The effect of different beverages on the surface characteristics of PEEK and PEKK polymers.

Purpose: To evaluate the effects of various beverages on surface roughness and microhardness of PEEK and PEKK polymers.

Methods: Rectangular-shaped PEEK and PEKK polymers were fabricated and examined in the study. The specimens were immersed for 28 days at 37°C in red wine, coffee, and distilled water.

Voice Analysis in Dogs with Deep Learning: Development of a Fully Automatic Voice Analysis System for Bioacoustics Studies.

Extracting behavioral information from animal sounds has long been a focus of research in bioacoustics, as sound-derived data are crucial for understanding animal behavior and environmental interactions. Traditional methods, which involve manual review of extensive recordings, pose significant challenges. This study proposes an automated system for detecting and classifying animal vocalizations, enhancing efficiency in behavior analysis.

Dexmedetomidine Improves Learning Functions in Male Rats Modeling Cognitive Impairment by Modulating the BDNF/TrkB/CREB Signaling Pathway.

Dexmedetomidine (DEX) is a selective alpha-2 adrenergic receptor agonist with sedative and anxiolytic properties. Increasing evidence reports that DEX has a neuroprotective effect. In this study, we investigated the potential effects of DEX on learning and memory functions in rats with experimental cognitive impairment.

The Utilization of Acetaminophen for Managing PGE1-Induced Fever in Neonates with Critical Congenital Heart Disease.

Introduction: We aimed to retrospectively evaluate the use of acetaminophen, which may be a risk factor for the ductal canal, in the treatment of fever due to prostaglandin E1 (PGE1) infusion in newborns with critical congenital heart disease (CCHD).

Methods: The study included newborns who were followed-up in our neonatal intensive care unit with the diagnosis of critical congenital heart disease, developed fever due to PGE1 infusion and had acetaminophen administered for antipyretic treatment. The patent ductus arteriosus diameters of the patients were evaluated by echocardiographic imaging before intravenous acetaminophen treatment and at the end of the day of acetaminophen treatment.

Diagnosis of Multiple Organ Dysfunction in Neonates with Hypoxic-Ischemic Encephalopathy: Vasoactive Inotropic Score, Renal Score, Fibrosis-5 Index and Lactate/Albumin Ratio.

Background: Vasoactive inotrope score, renal score, fibrosis-5 index, and lactate-albumin ratio have not been investigated before in determining multiple organ dysfunctions accompanying infants with hypoxic-ischemic encephalopathy (HIE) in neonatal intensive care units (NICUs). The aim of this study was to determine whether multiple organ dysfunctions that may accompany HIE in infants are correlated with vasoactive inotrope score (VIS), renal score (RS), fibrosis-5 index (FIB-5), and lactate-albumin ratio (LAR), and whether these parameters can predict morbidity and mortality.

Methods: This is a retrospective study, and 106 newborns diagnosed with HIE and treated with hypothermia were included in the study.

Effect of splinting and kinesiotaping treatments on functional status, sleep quality and median nerve cross-sectional area in carpal tunnel syndrome: A single blind prospective randomized controlled study.

Background: The effect of conservative treatments on sleep quality in carpal tunnel syndrome is unclear.

Purpose: Comparing the effect of splinting and kinesiotaping in carpal tunnel syndrome on functional status, pain, grip strength, nerve cross-sectional area and sleep quality.

Study Design: Randomized controlled study.