Neonatal/infantile-onset genetic epilepsies: The utility of genetic testing for molecular etiology-specific diagnosis concerning therapeutic implications.

Objective: To evaluate the significance of genetic testing in neonatal- and infantile-onset genetic epilepsies (NIGEP) for enhanced molecular diagnosis with management implications.

Methods: A single-center cohort of 128 patients with NIGEP (aged 0-36 months) from 2010 to 2022 was retrospectively assessed. The diagnostic utility of genetic testing, including next-generation sequencing (NGS) and chromosome-based approaches, was surveyed to determine their impact on antiseizure medication adjustments and precision medicine.

Ligand-Assisted Colloidal Synthesis of Alkali Metal-Based Ternary Chalcogenide: Nanostructuring and Phase Control in Na-Cu-S System.

The development of sustainable and tunable materials is crucial for advancing modern technologies. We present a controlled synthesis of colloidal Na-Cu-S nanostructures. To overcome the reactivity difference between Na and Cu precursors toward chalcogens in a colloidal synthesis and to achieve metastable phase formation, we designed a single-source precursor for Cu and S.

Exploring Acceptance of Digital Health Technologies for Managing Non-Communicable Diseases Among Older Adults: A Systematic Scoping Review.

This review explores the acceptance of digital health (DH) technologies for managing non-communicable diseases (NCDs) among older adults (≥ 50 years), with an extended focus on artificial intelligence (AI)-powered conversational agents (CAs) as an emerging notable subset of DH. A systematic literature search was conducted in June 2024 using PubMed, Web of Science, Scopus, and ACM Digital Library. Eligible studies were empirical and published in English between January 2010 and May 2024.

Characterization and genomic analysis of Sharanji: a jumbo bacteriophage of Escherichia coli.

Background: Bacteriophages are the most genetically diverse biological entities in nature. Our current understanding of phage biology primarily stems from studies on a limited number of model bacteriophages. Jumbo phages, characterized by their exceptionally large genomes, are less frequently isolated and studied.

The Impact of the COVID-19 Pandemic and Lockdowns on Sex Workers in West Bengal, India.

India's COVID-19 lockdowns were among the strictest globally, and sex workers were uniquely impacted. Extremely limited literature has examined pandemic consequences on sex workers. We use a qualitative approach to examine the impact of the COVID-19 pandemic and lockdowns on the lives and livelihoods of sex workers in urban West Bengal, India.

The Effect of Nursing Interventions in Women With Gestational Hypertension: A Systematic Review and Meta-Analysis.

Pregnancy-related hypertensive disorders are significant global causes of maternal morbidity and mortality. Quality nursing care is essential for pregnant women with hypertension to ensure a healthy pregnancy and delivery. This study aimed to systematically synthesize evidence on the effectiveness of nursing interventions for women with gestational hypertension.

Determination of Morphogenetic and Diurnal Variability in Phenolic and Flavonoid Content of Echinacea purpurea (L.) Moench: A Potential Source of Natural Anioxidants.

Echinacea purpurea (L.) Monech has a diverse range of phytochemicals, including flavonoids, polyphenols, phenolic acids, alkylamides, and terpenoids. Phenolic and flavonoid substances derived from the leaves and flowers have been used for treatment of illness.

Gold Nanoparticle Incorporated Graphene Oxide as a SERS Platform for Ultratrace Antibody Free Sensing of the Cancer Biomarker CEA.

A simple, fast, low-cost, and efficient method is designed for the synthesis of graphene oxide (GO) (20 nm) from graphite using a strong oxidant Ce(IV). GO is further modified with gold nanoparticles (AuNPs) (5-8 nm) to generate a AuGO nanocomposite (25 nm). Raman spectral analyses confirm that the synthesized AuGO has a potential selective sensing ability for the cancer biomarker carcinoembryonic antigen (CEA) in serum.

Trajectories of microbiome-derived bile acids in early life - insights into the progression to islet autoimmunity.

Recent studies reveal that gut microbes produce diverse bile acid conjugates, termed microbially conjugated bile acids (MCBAs). However, their regulation and health effects remain unclear. Here, we analyzed early-life MCBA patterns and their link to islet autoimmunity.

Comparison of Standard and Global Coagulation Tests in Hemodialysis Patients.

Background: Chronic kidney disease (CKD) is associated with an increased tendency of bleeding and thrombosis. There are multiple factors that interact with each other to cause either in CKD patients. Conventional or standard coagulation tests (SCT) have several limitations.

Imaging biomarkers and artificial intelligence for diagnosis, prediction, and therapy of macular fibrosis in age-related macular degeneration: Narrative review and future directions.

Macular fibrosis is an end-stage complication of neovascular Age-related Macular Degeneration (nAMD) with a complex and multifactorial pathophysiology that can lead to significant visual impairment. Despite the success of anti-vascular endothelium growth factors (anti-VEGF) over the last decade that revolutionised the management and visual prognosis of nAMD, macular fibrosis develops in a significant proportion of patients and, along with macular atrophy (MA), is a main driver of long-term vision deterioration. There remains an unmet need to better understand macular fibrosis and develop anti-fibrotic therapies.

Factors associated with patient and health care system delay among migrant and local tuberculosis patients in Istanbul: a cross-sectional study.

Background: Effective tuberculosis (TB) management requires timely diagnosis and immediate treatment initiation. The urgency for diagnosing and treating TB is particularly acute among immigrants, who face heightened health risks due to factors such as poverty, hazardous working conditions, and limited healthcare access. The objective of this study was to examine the characteristics of patient and health care delays among migrant and local TB patients in Istanbul and to identify factors associated with delays in the diagnosis and treatment of TB in both migrant and local patients.

The Predictive Power of Intraoperative Surgical Apgar Scores in Foreseeing Renal Function after Radical Nephrectomy.

Introduction: This study was conducted to evaluate the predictive power of the Surgical Apgar Score (SAS) based on surgical blood loss, the lowest intraoperative heart rate and mean arterial pressure in foreseeing short- and long-term effects of radical nephrectomy (RN) on renal function.

Methods: A prospective investigation was conducted on 111 patients who underwent RN for kidney tumors at a tertiary hospital between 2016 and 2019. The SAS and age-adjusted Charlson Comorbidity Index (CCI) scores were calculated in relation to glomerular filtration rates (GFR) changes on postoperative 1st day, 3rd and 12th months.

How Do Molecular Crowders Influence Ligand Binding Kinetics with G-Quadruplex DNA? The Role of Bound Water.

Understanding the kinetics of ligand interaction with G-quadruplex DNA (GqDNA) in a crowded cell-like environment is of paramount importance in biology and pharmacology, as it elucidates the effect of molecular crowders on reaction rates governing these interactions─a process that largely remains unexplored. In this study, we investigate the binding/unbinding kinetics of a G-quadruplex stabilizing benzophenoxazine ligand, cresyl violet (CV), with a human telomeric hybrid GqDNA structure using fluorescence correlation spectroscopy (FCS) and molecular dynamics (MD) simulations. Experiments are conducted with and without 10% and 20% (w/v) ethylene glycol (EG), PEG200 and PEG6000 crowders.

Optimising Beyond-Use Date Management and Workload to Reduce Intravenous Medication Errors: A Targeted Intervention Study.

Aim(s): To evaluate the effectiveness of targeted interventions in optimising Beyond-Use Date (BUD) management and workload distribution to reduce intravenous (IV) medication errors and improve patient safety in a resource-limited hospital setting.

Design: This study employed a pre- and post-intervention observational design.

Methods: A four-month intervention was conducted at a large tertiary hospital in China, following a baseline assessment of IV medication practices.

Implementation of a Language-Concordant, Culturally Tailored Inpatient Lactation Program.

Importance: Benefits of breastfeeding are extensive, but racial and ethnic disparities persist. Mama Sana (Spanish for healthy mother) is a bilingual, culturally tailored program that aims to reduce breastfeeding inequities.

Objective: To examine differences in lactation support and breastfeeding outcomes among Spanish-speaking Hispanic birthing parents who participated in Mama Sana compared with a historical control (pre-Mama Sana) group.

Liver Transplantation as a Definitive Treatment for Homozygous Protein C Deficiency.

Protein C is a vitamin K-dependent anticoagulant glycoprotein that inhibits activated factors V and VIII once activated by thrombin while promoting fibrinolysis. Patients with homozygous protein C deficiency generally present shortly after birth with purpura fulminans, retinal hemorrhage, and signs of the central nervous system or renal thrombosis. This case reports the first case of homozygous protein C deficiency in the UAE successfully treated with liver transplantation.

The hepatoprotective potential of ferulic acid against a spectrum of pharmaceuticals and toxic compounds.

Despite advancements in medicine, drug-induced liver injury continues to pose regulatory and clinical challenges. Ferulic acid, a naturally occurring polyphenol found in vegetables, fruits, and grains, has gained attention for its therapeutic properties. We report the hepatoprotective effects of ferulic acid against a range of pharmaceuticals and toxic compounds.

Inadequacies in uveitis: misnomers, incongruencies, persistence of obsolete terminologies & inappropriate guidelines, treatment inadequacies, and misinterpretations.

Background: Inadequacies in medicine are manifold including inadequate influence of opinion leaders and consensus groups on terminology, diagnostic criteria and treatment guidelines, obsolete classifications and terms as well as misinterpretations of disease mechanisms. This is no different for uveitis and possibly even more pronounced as these are rare entities.

Purpose: To underline inadequacies in uveitis including inadequate diagnostic criteria and treatment guidelines, misnomers, obsolescence of terminology, misinterpretation of disease processes and inadequate or underuse of investigative modalities in uveitis.

Outcome of photodynamic therapy with Rose Bengal in conjunction with topical PHMB and chlorhexidine combination in Acanthamoeba keratitis.

Purpose: To report the outcome of Acanthamoeba keratitis, with early addition of Photo-dynamic antimicrobial therapy with Rose Bengal (PDAT-RB) to the medical treatment (combination of 0.02% Polyhexamethylene Biguanide (PH)and 0.02% chlorhexidine(CH)).

Unlocking the Therapeutic Potential of the Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A Inhibitors in Alzheimer's Diseases.

With 60-70% of all occurrences of dementia, Alzheimer's disease (AD), an advancing neurological illness, is one of the most frequent causes of dementia. Even though the exact etiology of AD is still unidentified, persons who have the disease have been found to have a number of abnormalities in their brains. Apart from the buildup of amyloid-β plaques inside the brain tissue, it has been demonstrated that abnormal tau protein phosphorylation increases the risk of neuronal death.

Report of a novel pathogenic orthohantavirus in Tucuman, Argentina.

The confirmation of two cases of hantavirus pulmonary syndrome (HPS) in the city of San Miguel de Tucuman, province of Tucuman, is described in the present study. In 2021, the diagnosis of two patients with HPS with no history of travel outside the province was confirmed. The infection was determined by serology in both cases.

Impact of hospital-based early detection on management in chronic kidney disease: the CKD Stewardship study (CKD-S) - protocol for a prospective, multicentre, observational cohort study.

Introduction: Chronic kidney disease (CKD) causes significant morbidity and mortality. Medical therapies can reduce the progression of disease by up to 50%. CKD is undiagnosed in the majority of people who have it, resulting in undertreatment.