On the Feasibility of Skin Water Content Imaging Adjuvant to Tissue Oximetry.

Unlabelled: Oxygen supply to tissues can be seriously impacted during wound healing. In particular, edema can increase the distance between capillaries, thus decreasing oxygen supply to cells. Thus, the detection of edema, preferably at the preclinical stage, is of great importance.

Optimization of Band Selection in Multispectral and Narrow-Band Imaging: An Analytical Approach.

Unlabelled: Hyperspectral imaging is a promising clinical imaging modality with multiple applications in wound care, dermatology, and ophthalmology. However, with current technologies, hyperspectral imagers are relatively large and expensive devices, mainly affordable only by hospitals. Multispectral imaging can be a cost-effective alternative for hyperspectral imaging and is capable of bringing diagnostics to primary health care.

Methemoglobin: A New Way to Distinguish Burn Depth.

Unlabelled: In this work, we present a model of dynamics of methemoglobin (MetHb) in burn injuries and show that measuring levels of MetHb can distinguish thickness in burn injuries.

Methods: The model of dynamics of MetHb levels in blood of subjects with burn injuries has been developed based on the vascular morphology of the skin. The model contains burn-specific and non-specific components.

Mathematical Model of an Innate Immune Response to Cutaneous Wound in the Presence of Local Hypoxia.

We developed a 2D multi-agent stochastic model of interaction between cellular debris, bacteria and neutrophils in the surface cutaneous wound with local hypoxia. Bacteria, which grow logistically with a maximum carrying capacity, and debris are phagocytosed by neutrophils with probability determined by the partial pressure of oxygen in the tissue, pO 2  = 4-400 mmHg, according to the Michaelis-Menten equation with K m  = 40 mmHg. The influx of new neutrophils depends linearly (k = 0.

Diffuse reflectance spectroscopy in Barrett's esophagus: developing a large field-of-view screening method discriminating dysplasia from metaplasia.

We evaluated diffuse reflectance spectroscopy implemented as a small field-of-view technique for discrimination of dysplasia from metaplasia in Barrett's esophagus as an adjuvant to autofluorescence endoscopy. Using linear discriminant analysis on 2579 spectra measured in 54 patients identified an optimum a 4-wavelength classifier (at 485, 513, 598 and 629 nm). Sensitivity and specificity for a test data set were 0.