Hereditary haemorrhagic telangiectasia.

Hereditary haemorrhagic telangiectasia (HHT) is a vascular dysplasia inherited as an autosomal dominant trait and caused by loss-of-function pathogenic variants in genes encoding proteins of the BMP signalling pathway. Up to 90% of disease-causal variants are observed in ENG and ACVRL1, with SMAD4 and GDF2 less frequently responsible for HHT. In adults, the most frequent HHT manifestations relate to iron deficiency and anaemia owing to recurrent epistaxis (nosebleeds) or bleeding from gastrointestinal telangiectases.

The effect of TikTok use on internet addiction of college students in Somalia: a cross-sectional study.

This study aimed to assess the effect of TikTok use on the internet addiction of college students in Somalia. This cross-sectional study was conducted with 210 students at the faculty of health sciences of a university in Mogadishu, Somalia. The data were obtained with the Individual Information Form and Young Internet Addiction Test-Short Form.

Lactoferrin as a Versatile Agent in Nanoparticle Applications: From Therapeutics to Agriculture.

Nanoparticles (NPs) have emerged as a potent choice for various applications, from drug delivery to agricultural studies, serving as an alternative and promising methodology for future advancements. They have been widely explored in delivery systems, demonstrating immense promise and high efficiency for the delivery of numerous biomolecules such as proteins and anticancer agents, either solely or modified with other compounds to enhance their capabilities. In addition, the utilization of NPs extends to antimicrobial studies, where they are used to develop novel antibacterial, antifungal, and antiviral formulations with advanced characteristics.

Validity and reliability of Glittre activities of daily living test in lower-limb prosthetic users.

Background: Functional capacity assessments have an important role in determining the level of mobility in lower-limb prosthetic users.

Objectives: Our aim was to investigate the reliability and validity of the Glittre activities of daily living (ADL) test in lower-limb prosthetic users.

Study Design: A cross-sectional study.

Single and combined effect of chrysin and N-acetylcysteine against deltamethrin exposure in rats.

Effects of chrysin and N-acetylcysteine on deltamethrin exposure in rats were investigated. Eighty male Wistar Albino rats, weighing between 150 and 200 g and aged 2-3 months, were used and evenly allocated into eight groups. The control group of rats received a corn oil vehicle.

The potential of lactoferrin as antiviral and immune-modulating agent in viral infectious diseases.

Emerging infectious diseases are caused by unpredictable viruses with the dangerous potential to trigger global pandemics. These viruses typically initiate infection by utilizing the anionic structures of host cell surface receptors to gain entry. Lactoferrin (Lf) is a multifunctional glycoprotein with multiple properties such as antiviral, anti-inflammatory and antioxidant activities.

Gold Nanoparticles in Nanomedicine: Unique Properties and Therapeutic Potential.

Gold nanoparticles (NPs) have demonstrated significance in several important fields, including drug delivery and anticancer research, due to their unique properties. Gold NPs possess significant optical characteristics that enhance their application in biosensor development for diagnosis, in photothermal and photodynamic therapies for anticancer treatment, and in targeted drug delivery and bioimaging. The broad surface modification possibilities of gold NPs have been utilized in the delivery of various molecules, including nucleic acids, drugs, and proteins.

Gold Nanoparticles: Multifunctional Properties, Synthesis, and Future Prospects.

Gold nanoparticles (NPs) are among the most commonly employed metal NPs in biological applications, with distinctive physicochemical features. Their extraordinary optical properties, stemming from strong localized surface plasmon resonance (LSPR), contribute to the development of novel approaches in the areas of bioimaging, biosensing, and cancer research, especially for photothermal and photodynamic therapy. The ease of functionalization with various ligands provides a novel approach to the precise delivery of these molecules to targeted areas.

The relationship between psychological resilience, coping strategies and fear of cancer recurrence in patients with breast cancer undergoing surgery: A descriptive, cross-sectional study.

Purpose: This study aims to determine the relationship between psychological resilience, coping strategies and the fear of cancer recurrence in women who have undergone surgical procedures due to breast cancer.

Methods: The study was conducted using a descriptive, cross-sectional, and correlational research design. The sample of the study consisted of 252 women.

Antipsychotic-Treated Schizophrenia Patients Develop Inflammatory and Oxidative Responses Independently From Obesity: However, Metabolic Disturbances Arise From Schizophrenia-Related Obesity.

Objective: To define the impact of obesity on inflammatory and oxidative disturbances in antipsychotic-treated schizophrenia patients.

Methods: Several cytokines, inflammatory, metabolic, and oxidative status markers were evaluated in obese (n = 40) and non-obese (n = 40) antipsychotic-treated patients and compared with age-and BMI-matched controls (n = 80).

Results: Schizophrenia patients had higher leptin, TNF-α, adiponectin, visfatin, resistin, P-selectin, NPY, BDNF, CD40-L, MCP-1, and malondialdehyde, and lower IL-6, ghrelin, neopterin, and vitamin E levels compared to their respective controls (p < 0.

Silver Nanoparticles in Therapeutics and Beyond: A Review of Mechanism Insights and Applications.

Silver nanoparticles (NPs) have become highly promising agents in the field of biomedical science, offering wide therapeutic potential due to their unique physicochemical properties. The unique characteristics of silver NPs, such as their higher surface-area-to-volume ratio, make them ideal for a variety of biological applications. They are easily processed thanks to their large surface area, strong surface plasmon resonance (SPR), stable nature, and multifunctionality.

Ineffectiveness of therapeutic plasma exchange as a last resort in severe COVID-19 cases: Experience from a tertiary intensive care unit.

Aim: Several studies have suggested that cytokine release syndrome (CRS) can be controlled by therapeutic plasma exchange (TPE) treatment. In this study, it was aimed to evaluate the efficacy of TPE treatment in patients who developed life-threatening respiratory failure syndrome (SARS) due to COVID-19 infection.

Methods: In this retrospective, case-control study, patients, who developed SARS, were infected with the COVID-19 virus, and required intensive care unit (ICU) admission were included.

Spontaneous and Surgical Resolution of Maculopathy in Bilateral Optic Disc Pit After Posterior Vitreous Detachment: A Case Report.

Purpose: To report a case of bilateral optic disc pit (ODP) maculopathy using a different treatment approach.

Methods: Observational case report.

Results: A 17-year-old male presented with blurred vision in both eyes.

Exploring the efficacy and tolerability of two-injection start regimen of long-acting aripiprazole: A descriptive case series analysis.

Bipolar disorder is the fourth most debilitating psychiatric illness in the world regarding Disability Adjusted Life Years and manic episodes frequently lead to lengthy hospitalizations which restricts the freedom of patients. Therefore, decreasing the length of hospitalization with safer agents is of utmost importance in the treatment of manic episodes. Aripiprazole is a medication known for its efficacy in managing mania associated with bipolar disorder.

Silver Nanoparticles: A Comprehensive Review of Synthesis Methods and Chemical and Physical Properties.

Recently, silver nanoparticles (NPs) have attracted significant attention for being highly desirable nanomaterials in scientific studies as a result of their extraordinary characteristics. They are widely known as effective antibacterial agents that are capable of targeting a wide range of pathogens. Their distinct optical characteristics, such as their localized surface plasmon resonance, enlarge their utilization, particularly in the fields of biosensing and imaging.

Treatment of table olive processing wastewater with US/UV processes.

Agroindustry factory's such as the table olive industry etc. that gain importance in the economies of Mediterranean countries. Conventional treatment methods are not effective for treating table olive processing wastewater due to its unique composition.

Iatrogenic arterial vasospasm during mechanical thrombectomy requiring treatment with intra-arterial nimodipine might be associated with worse outcomes.

Background And Purpose: Vasospasm is a common iatrogenic event during mechanical thrombectomy (MT). In such circumstances, intra-arterial nimodipine administration is occasionally considered. However, its use in the treatment of iatrogenic vasospasm during MT has been poorly studied.

Evaluation of the effect of ocular dominance on macular microcirculation via swept-source optical coherence tomography angiography.

Purpose: To determine the existence of differences in the retinal microcirculation of dominant and non-dominant eyes, as well as of interocular differences in macular microcirculation, using swept-source optical coherence tomography angiography (OCTA).

Methods: In total, 122 eyes of 61 individuals were enrolled in this cross-sectional study. Measurements were taken using the swept-source optical coherence tomography Triton device (Topcon Corp, Tokyo, Japan) coupled with non-invasive OCTA technology.

Extensive myocardial calcifications: a systematic literature review of a rare pathological phenomenon.

Introduction: Myocardial calcifications (MC) represent a relatively rare pathological process, which may accompany different cardiovascular conditions and can be broadly categorized as dystrophic or metastatic. Myocardial infarction (MI) has been traditionally regarded as the main cause of MC overall; however, no updated comprehensive data on the relative incidence of different forms of MC is available. The purpose of this systematic review of the literature is to analyze the currently available evidence on MC in terms of pathophysiology, diagnosis, and clinical presentation.

Polyphenols: Secondary Metabolites with a Biological Impression.

Polyphenols are natural compounds which are plant-based bioactive molecules, and have been the subject of growing interest in recent years. Characterized by multiple varieties, polyphenols are mostly found in fruits and vegetables. Currently, many diseases are waiting for a cure or a solution to reduce their symptoms.