Prognostic value of HER2 2 + expression in patients with TNBC receiving adjuvant capecitabine.

Background: In triple-negative breast cancer (TNBC) patients receiving adjuvant capecitabine, the impact of HER2 expression on survival outcomes is unclear.

Methods:  Between June 2017 and December 2023, 112 patients with TNBC who received adjuvant capecitabine due to residual masses after neoadjuvant chemotherapy (NACT) in three hospitals were identified. HER2 is analyzed through immunohistochemistry (IHC) and/or in situ hybridization in the core biopsy and/or post-surgical histopathologies.

Expectations and Outcomes From Glucagon-Like Peptide-1 Receptor Agonists As Adjunct Treatment for Type 1 Diabetes - Case Presentations.

Background: Type 1 diabetes (T1D) is characterized by the autoimmune destruction of pancreatic beta cells, leading to lifelong insulin dependence. Despite advancements in insulin therapies and glucose monitoring, maintaining optimal blood glucose control remains challenging with common issues like weight gain and glucose variability. Glucagon-like peptide 1 receptor agonists (GLP-1 RAs), approved for type 2 diabetes and obesity, are being explored off-label for T1D.

Development of a superhydrophobic and superoleophilic halloysite nanotube/phenyltriethoxysilane-coated melamine sponge sorbent material with high performance in supercritical CO atmosphere for the selective and effective oil spill cleanup and oil-water separation.

In this study, activated halloysite nanotube (HNT) and phenyltriethoxysilane (PTES) were utilized for the first time to fabricate modified HNT materials and coat them onto melamine sponge (MS) substrate in the supercritical carbon dioxide (scCO) atmosphere. The successful coating of MS substrate was confirmed using SEM, EDS, XPS, and contact angle measurements. The drainage technique applied in the CO medium achieved the uniform coating of both the inner and outer surfaces of the MS.

Narrow escape with imperfect reactions.

The imperfect narrow escape problem considers the mean first passage time (MFPT) of a Brownian particle through one of several small, partially reactive traps on an otherwise reflecting boundary within a confining domain. Mathematically, this problem is equivalent to Poisson's equation with mixed Neumann-Robin boundary conditions. Here, we obtain this MFPT in general three-dimensional domains by using strong localized perturbation theory in the small trap limit.

Supercritical CO-Mediated Decellularization of Bovine Spinal Cord Meninges: A Comparative Study for Decellularization Performance.

The extracellular matrix (ECM) of spinal meninge tissue closely resembles the wealthy ECM content of the brain and spinal cord. The ECM is typically acquired through the process of decellularizing tissues. Nevertheless, the decellularization process of the brain and spinal cord is challenging due to their high-fat content, in contrast to the spinal meninges.

The effect of hydrocolloid tape and facial massage on nasal injury and stress levels in premature infants on noninvasive mechanical ventilation: Randomized controlled trial.

Aim: The aim of this study was to evaluate the effect of hydrocolloid patch use and facial massage on nasal septum injury and stress in premature infants receiving noninvasive mechanical ventilation (NIMV) support.

Methods: The study was conducted as a single-blind, randomised controlled experimental study with 108 premature infants between 28 and 34 gestation weeks (Hydrocolloid patch group: 36, facial massage group: 36, control group: 36) who were hospitalised in the 3rd level neonatal intensive care unit (NICU) between February 2023 and February 2024, received NIMV support and met the inclusion criteria. The data of the study were collected using the Neonatal Descriptive Information Form, Neonatal Skin Condition Assessment Scale (NSCAS), Nasal Injury Scale (NIS) and Neonatal Stress Scale (NSS).

Metaheuristic optimized complex-valued dilated recurrent neural network for attack detection in internet of vehicular communications.

The Internet of Vehicles (IoV) is a specialized iteration of the Internet of Things (IoT) tailored to facilitate communication and connectivity among vehicles and their environment. It harnesses the power of advanced technologies such as cloud computing, wireless communication, and data analytics to seamlessly exchange real-time data among vehicles, road-side infrastructure, traffic management systems, and other entities. The primary objectives of this real-time data exchange include enhancing road safety, reducing traffic congestion, boosting traffic flow efficiency, and enriching the driving experience.

Associations between stages of diabetic polyneuropathy and quality of life, neuropathic pain, and well-being: A multicenter, cross-sectional analysis based on electroneuromyographic findings.

Aim: This study aimed to investigate the relationship between electrophysiological findings of diabetic neuropathy (DN) and patients' quality of life, neuropathic pain levels, and well-being.

Materials And Methods: A cross-sectional study was conducted in 12 centers in Turkey. DN patients were categorized into four stages based on electrophysiological findings using the Baba classification.

Prognostic impact of elevated C-reactive protein and procalcitonin in patients with extensive-stage small cell lung cancer.

Small cell lung cancer (SCLC) constitutes around 15% of lung cancer cases and stands as the primary cause of cancer-related fatalities in men and the second leading cause in women globally. In this study, our objective was to evaluate the levels of C-reactive protein (CRP) and procalcitonin (PCT) in newly diagnosed extensive-stage SCLC patients without evidence of infection. We aimed to demonstrate that elevated CRP and PCT levels may not solely indicate infection but could also be elevated in malignancies.

Efficacy of Nematode Against Lesser Mealworm () Populations from Poultry Farms in Türkiye.

In the veterinary field, particularly in the poultry farming sector, (Panzer, 1797) (Coleoptera: Tenebrionidae) is a significant pest that causes economic losses and acts as a vector for various pathogens. This study is the first to evaluate the efficacy of the entomopathogenic nematode Filipjev, 1934 against both the larval (fifth instar) and imago (adult) of from various Turkish populations. The insects were collected from six poultry farms in the provinces of Balikesir, Bolu, Canakkale, Manisa, and Izmir in Türkiye, bred, and then tested at concentrations ranging from 25 to 200 infective juveniles (IJs) per milliliter.

Decreased Aortic Elasticity in Rheumatoid Arthritis: An Early Sign of Atherosclerosis and Predictive Factors.

Background: Atherosclerosis is increased in patients with rheumatoid arthritis (RA) and early diagnosis of vascular disease leads to better outcome. Our aim was to evaluate whether aortic elasticity decreases in the subclinical stage of atherosclerosis in RA patients without any cardiovascular disease and to determine disease-related risk factors.

Methods: One hundred fourteen patients with RA, 50 patients with spondyloarthritis, and 50 healthy control were included in this study.

Effects of the eccentric chin closure exercise on submental muscle activation, muscle strength, dysphagia limit, perceived exertion and pain in healthy volunteers: A prospective, randomized parallel group study.

Objective(s): Eccentric Chin Closure (ECC) exercise is a model designed to strengthen the suprahyoid muscles, aligned with the principles of eccentric exercise and the characteristics of these muscles. This study aimed to investigate the effects of the ECC exercise on submental muscle activation, muscle strength, dysphagia limit, perceived exertion, and pain, in comparison to the Shaker and Chin-Tuck Against Resistance (CTAR) exercises.

Methods: In this parallel randomized controlled trial, for the initial assessment fifty-four healthy volunteers aged between 19-28 years with submental activations were recorded during the isotonic components of the Shaker, CTAR, and ECC exercises using surface electromyography.

Infections and treatment modalities in pediatric victims of the Kahramanmaraş/Türkiye earthquake.

Background: Data on infections in children are scarce in the context of earthquakes. Here, we describe our clinical experiences regarding infections in pediatric victims after the earthquakes in Kahramanmaraş/Türkiye.

Methods: Trauma patients after the Kahramanmaraş earthquakes, aged under 18 years and admitted to our hospital, were evaluated retrospectively.

Ultrasonic dissection versus electrocautery dissection in laparoscopic cholecystectomy for acute cholecystitis: a randomized controlled trial (SONOCHOL-trial).

Background: Laparoscopic cholecystectomy with ultrasonic dissection presents a compelling alternative to conventional electrocautery. The evidence for elective cholecystectomy supports the adoption of ultrasonic dissection, citing advantages such as reduced operating time, diminished bleeding, shorter hospital stays and decreased postoperative pain and nausea. However, the efficacy of this procedure in emergency surgery and patients diagnosed with acute cholecystitis remains uncertain.

A New Objective Diagnostic Tool for Attention-Deficit Hyper-Activity Disorder (ADHD): Development of the Distractor-Embedded Auditory Continuous Performance Test.

: Attention-Deficit Hyperactivity Disorder (ADHD) is a prevalent neurodevelopmental disorder characterized by inattention, hyperactivity, and impulsivity. Traditional diagnostic methods, which depend on subjective assessments, often lack precision. This study evaluates the validity and reliability of a newly developed diagnostic tool, the Distractor-Embedded Auditory Continuous Performance Test (da-CPT), which integrates auditory stimuli with distractors to enhance the clinical utility of ADHD diagnosis.

Consensus Report on Glucagon-Like Peptide-1 Receptor Agonists as Adjunctive Treatment for Individuals With Type 1 Diabetes Using an Automated Insulin Delivery System.

With increasing prevalence of obesity and cardiovascular diseases, there is a growing interest in the use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) as an adjunct therapy in type 1 diabetes (T1D). The GLP-1RAs are currently not approved by the US Food and Drug Administration for the treatment of T1D in the absence of randomized controlled trials documenting efficacy and safety of these agents in this population. The Diabetes Technology Society convened a series of three consensus meetings of clinicians and researchers with expertise in diabetes technology, GLP-1RA therapy, and T1D management.

Reliability and Validity of the Turkish Version of the Deglutition Handicap Index.

The Deglutition Handicap Index (DHI) is a self-reported questionnaire focus on dysphagia related quality of life of patients. The present study was aimed to translate the DHI into Turkish, and investigate the reliability and validity of the Turkish version of the DHI (T-DHI). A total of 100 patients with different diagnoses participated.