Recent advances in the biosynthesis of polysaccharide-based antimicrobial glycoconjugate vaccines.

Glycoconjugate vaccines are a vital category of effective and safe commercial vaccines that have significantly reduced the global prevalence of drug-resistant bacterial infections. These vaccines are synthesized by covalently linking bacterial polysaccharide antigens to a carrier protein. Given that they produce a stronger and longer-lasting immune response than pure polysaccharides that activate only B cells, glycoconjugate vaccines have become one of the most promising vaccine types.

β2 integrin regulates neutrophil trans endothelial migration following traumatic brain injury.

Neutrophils are the first responders among peripheral immune cells to infiltrate the central nervous system following a traumatic brain injury (TBI), triggering neuroinflammation that can exacerbate secondary tissue damage. The precise molecular controls that dictate the inflammatory behavior of neutrophils post-TBI, however, remain largely elusive. Our comprehensive analysis of the molecular landscape surrounding the trauma in TBI mice has revealed a significant alteration in the abundance of β2 integrin (ITGB2), predominantly expressed by neutrophils and closely associated with immune responses.

Management of large or giant Extracranial carotid artery aneurysms: a single-center experience.

Background: Extracranial carotid artery aneurysm (ECCA) is an infrequent disease with an incidence of less than 1%. However, our understanding is still incomplete, and the preferred method to treat ECAA remains unknown.

Methods: To share our initial experience with treatment options for large ECCAs.

Development and validation of a deep learning model for prediction of intracranial aneurysm rupture risk based on multi-omics factor.

Objective: The clinical ability of radiomics to predict intracranial aneurysm rupture risk remains unexplored. This study aims to investigate the potential uses of radiomics and explore whether deep learning (DL) algorithms outperform traditional statistical methods in predicting aneurysm rupture risk.

Methods: This retrospective study included 1740 patients with 1809 intracranial aneurysms confirmed by digital subtraction angiography at two hospitals in China from January 2014 to December 2018.

An immunogenic cell death-related regulators classification patterns and immune microenvironment infiltration characterization in intracranial aneurysm based on machine learning.

Background: Immunogenic Cell Death (ICD) is a novel way to regulate cell death and can sufficiently activate adaptive immune responses. Its role in immunity is still emerging. However, the involvement of ICD in Intracranial Aneurysms (IA) remains unclear.

Latitudinal and elevational patterns of phylogenetic structure in forest communities in China's mountains.

The phylogenetic structure incorporates both ecological and evolutionary processes to explain assembly of a local community. The "phylogenetic niche conservatism" (PNC) hypothesis suggests that distributions of species along environmental gradients reflect both ancestral traits and ecological fitness of individual species The temperature is generally regarded to change in similar ways along both latitudinal and elevational gradients but with different historical contingence. Therefore, comparing the latitudinal and elevational patterns of phylogenetic structure of communities is of help to depict the effects of ecological and evolutionary processes in shaping the community assembly.