Impact of restorative materials on biomechanical behavior of endocrown and post-core restorations: A 3-dimensional finite element analysis.

Purpose: This study evaluated biomechanical behavior of endocrown and post-core restorations produced from computer aided design/computer aided manufacturing (CAD/CAM) and traditional materials in severely damaged teeth that lack a ferrule and assessed the associated failure risk of resin cement.

Methods: A phantom maxillary central incisor and mandibular second premolar were trimmed 1 mm coronally to the cemento-enamel junction, the root canals were enlarged, and the teeth were scanned. Data were transferred to a solid modeling software.

Exploring the potential of artificial intelligence chatbots in prosthodontics education.

Background: The purpose of this study was to evaluate the performance of widely used artificial intelligence (AI) chatbots in answering prosthodontics questions from the Dentistry Specialization Residency Examination (DSRE).

Methods: A total of 126 DSRE prosthodontics questions were divided into seven subtopics (dental morphology, materials science, fixed dentures, removable partial dentures, complete dentures, occlusion/temporomandibular joint, and dental implantology). Questions were translated into English by the authors, and this version of the questions were asked to five chatbots (ChatGPT-3.

The Effect of Proprioceptive Training on Technical Soccer Skills in Youth Professional Soccer.

This study analyzes the effects of proprioceptive training on the physical fitness and soccer-specific technical skills of young professional soccer players. Twenty-eight male professional soccer players from the Türkiye Football Federation's Third League, aged 20.46 ± 1.

Benchmarking DNA Sequence Models for Causal Regulatory Variant Prediction in Human Genetics.

Machine learning holds immense promise in biology, particularly for the challenging task of identifying causal variants for Mendelian and complex traits. Two primary approaches have emerged for this task: supervised sequence-to-function models trained on functional genomics experimental data and self-supervised DNA language models that learn evolutionary constraints on sequences. However, the field currently lacks consistently curated datasets with accurate labels, especially for non-coding variants, that are necessary to comprehensively benchmark these models and advance the field.

Management of extremity and pelvic fractures in earthquake: our observations and recommendations.

Background: Earthquakes frequently cause injuries to the musculoskeletal system. Studies conducted after earthquakes often report on injured limbs, fractures, and surgeries. This study aimed to enhance preparedness for future earthquakes by acquiring knowledge about the prevalence of fractures and the relationship between fracture types and injury mechanisms.

Efficacy of Tract Embolization on Reducing Pneumothorax in CT-Guided Transthoracic Lung Biopsies: Comparison of Saline and Autologous Blood Patch.

Rationale And Objectives: This study aimed to evaluate the effectiveness of two techniques "autologous blood patch (ABP) and saline sealing" in preventing pneumothorax during CT-guided percutaneous transthoracic lung biopsies (PTTLB).

Materials And Methods: We analyzed 218 PTTLB procedures performed on 202 patients, categorizing them into three groups: those receiving ABP, those receiving saline, and a control group with no intervention. We assessed pneumothorax and catheter drainage rates and analyzed potential risk factors, including demographics, procedural positioning, pleura-skin distance, lesion characteristics, and emphysema scores.

Investigation of high school students' social emotional learning skills and social media use.

The current study aims to examine the association between high school students' social-emotional learning (SEL) skills and their use of social media, as well as to explore potential variations based on certain variables. The research utilized relational and comparative survey methodologies, with 325 high school students participating. Data were gathered through the administration of the "Social Emotional Learning Scale" and the "Social Media Use Scale.

Immediate and Short-Term Effect of Scapula Retraction Exercises on Subacromial Space: Do We Have Enough Evidence in Patients With Subacromial Pain?

Context: Limited information exists regarding the immediate and short-term effects of scapula retraction exercises (SREs) on acromiohumeral distance (AHD) in subacromial pain syndrome (SPS). This study's 2 main objectives were to investigate (1) the immediate effect of the SRE on AHD at varying shoulder abduction angles in patients with SPS and healthy controls and (2) the effect of the 8-week SRE program on AHD in patients with SPS.

Design: Cross-sectional and pre-post intervention designs were utilized on this study.

Caftaric acid attenuates kidney and remote organ damage induced by renal ischemia-reperfusion injury.

Oxidative stress and inflammation are indispensable components of ischemia-reperfusion (IR) injury. In this study, we investigated the effects of low and high doses of caftaric acid (CA) on reducing kidney and remote organ damage induced by IR. We divided Wistar rats into four groups: sham, IR, low (40 mg/kg body weight (BW)), and high (80 mg/kg BW) CA groups.

Protective Effects of Baicalein and Bergenin Against Gentamicin-Induced Hepatic and Renal Injuries in Rats: An Immunohistochemical and Biochemical Study.

Background: Drug-induced organ toxicity is a significant health concern, with gentamicin known for its effective antibacterial properties but also severe side effects, particularly cytotoxicity in liver and kidney tissues. This current study observed the preventive role of baicalein and bergenin against hepatic and renal injuries caused by gentamicin in rats.

Methods: Thirty-two male Sprague Dawley rats were divided into four groups, namely, control, gentamicin (gentamicin 80 mg/kg/day), baicalein (gentamicin 80 mg/kg/day + baicalein 100 mg/kg/day) and bergenin (gentamicin 80 mg/kg/day + bergenin 100 mg/kg/day).

Assessment of sinapic acid's protective effects against ethanol-induced gastric ulcers in rats.

This study evaluates the protective effects of sinapic acid (SA), a polyphenolic compound with diverse biological activities, against ethanol-induced gastric ulcers in rats. A gastric ulcer model was established using ethanol (ETH), and the experimental groups received either omeprazole (OMEP, 20 mg/kg) or SA at doses of 20 mg/kg and 40 mg/kg via oral gavage for 14 days. Biochemical markers, including total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), malondialdehyde (MDA), and myeloperoxidase (MPO) activity, were assessed alongside proinflammatory cytokines (tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and IL-6) using ELISA.

Determination of weight loss methods and effects among wrestlers before an official championship.

Introduction: It is known that combat athletes frequently lose weight before a competition. This study aimed to determine the weight loss methods before an official championship and the effects of these weight loss methods on the performance of wrestlers.

Method: The sample of the study consisted of 350 competitive wrestlers.

THE STING AGONIST VB-85247 INDUCES DURABLE ANTITUMOR IMMUNE RESPONSES BY INTRAVESICAL ADMINISTRATION IN A NON-MUSCLE INVASIVE BLADDER CANCER.

Bacillus Calmette-Guerin (BCG) is the current standard of care for non-muscle invasive bladder cancer (NMIBC), but recurrence is common. Additional therapeutic options are a major unmet medical need for treating unresponsive patients. Stimulator of Interferon Genes (STING) plays a central role in mounting innate and adaptive immune responses to tumor cells, and activation of STING is a promising immunotherapeutic approach.

SON-1010: an albumin-binding IL-12 fusion protein that improves cytokine half-life, targets tumors, and enhances therapeutic efficacy.

Background: Cytokines have been promising cancer immunotherapeutics for decades, yet only two are licensed to date. Interleukin-12 (IL-12) is a potent regulator of cell-mediated immunity that activates NK cells and interferon-γ (IFNγ) production. It plays a central role in multiple pathways that can enhance cancer cell death and modify the tumor microenvironment (TME).

Red cell distribution width to albumin ratio and mortality in acute pulmonary thromboembolism.

The red cell distribution width (RDW)/albumin ratio (RAR) is an inflammation-based prognostic biomarker. To date, its prognostic value in patients with pulmonary thromboembolism (PTE) has been investigated in only one study. This study aimed to assess the effect of RAR on mortality in patients with PTE.

Single and combined effect of chrysin and N-acetylcysteine against deltamethrin exposure in rats.

Effects of chrysin and N-acetylcysteine on deltamethrin exposure in rats were investigated. Eighty male Wistar Albino rats, weighing between 150 and 200 g and aged 2-3 months, were used and evenly allocated into eight groups. The control group of rats received a corn oil vehicle.

Glutaric aciduria type 1: Insights into diagnosis and neurogenetic outcomes.

Unlabelled: Glutaric aciduria type 1 (GA1) is a rare metabolic disorder characterized by a deficiency in the enzyme glutaryl-CoA dehydrogenase. This study aims to present the clinical, biochemical, genetic, and neuroimaging findings of GA1 patients, emphasizing the importance of early detection and the potential benefits of incorporating GA1 into NBS programs. The demographic, clinical, and laboratory findings of GA1 patients were reviewed retrospectively.

Reliability and validity of the Tampa Scale for Kinesiophobia in patients with traumatic hand-forearm injuries.

Objective: Fear of movement in patients with traumatic hand-arm injuries can negatively affect functional outcomes. Therefore, it is important to evaluate fear of movement in this patient population. The aim of this study was to investigate the validity and reliability of the Tampa Scale for Kinesiophobia in patients with traumatic hand-forearm injuries.

Insights Into the Group of Surgically Resectable But Nonoperable Patients With Colorectal Cancer.

Background: The incidence of colorectal cancer is expected to increase, particularly among patients with significant frailty and comorbidities. A subgroup of these patients may not be suitable for surgery because of the high risk of postoperative morbidity and mortality.

Objective: The aim of this study was to characterize the clinical outcomes, management, social status, and survival of patients deemed nonoperable because of comorbidity and/or frailty.

Outcomes of newborns screened for congenital hypothyroidism in Turkey - a single center experience.

Objectives: It was aimed to investigate the outcomes of babies referred to a tertiary health center in Turkey for evaluation primary congenital hypothyroidism (CH) through newborn screening.

Methods: The hospital files of 328 newborns who were referred for CH from newborn screening between June 2013 and June 2020 were retrospectively reviewed. The newborns were evaluated with their clinical characteristics at admission, as well as their follow-up data and final diagnoses.

Evaluation of the efficacy of diosmin and chrysin against tau-fluvalinate exposure in rats.

Tau-fluvalinate is a type 2 pyrethroid insecticide. Diosmin and chrysin are flavonoids with antioxidant and anti-apoptotic effects. Role of diosmin and chrysin against infavorable toxic effects caused by tau-fluvalinate and the underlying mechanisms of these effects were investigated.

Evaluation of polyaryletherketone materials as post-core abutments for removable partial dentures: A finite element analysis.

Objective: The purpose was to compare the biomechanical behavior of single-piece post-core restorations made from polyaryletherketone materials with fiber post-core restorations when serving as abutments for RPD using finite element analysis (FEA).

Methods: Phantom maxillary central incisor and mandibular second premolar were trimmed 1-mm coronally to cemento-enamel junction; root canals were enlarged and the teeth were scanned. Data was transferred to a solid modeling software.

The effect of embryo migration after embryo transfer with fresh oocyte donation cycles on pregnancy outcomes.

Embryo migration is defined as the movement of embryos to implant at the exact site in the endometrial cavity during assisted reproductive technology (ART). We aimed to evaluate the impact of embryo migration on clinical pregnancy (CPR) and live birth rates (LBR) in fresh oocyte donation (OD) cycles. A total of 611 fresh OD cycles was recruited in this prospective cohort study.

Designing realistic regulatory DNA with autoregressive language models.

-regulatory elements (CREs), such as promoters and enhancers, are DNA sequences that regulate the expression of genes. The activity of a CRE is influenced by the order, composition, and spacing of sequence motifs that are bound by proteins called transcription factors (TFs). Synthetic CREs with specific properties are needed for biomanufacturing as well as for many therapeutic applications including cell and gene therapy.

Costunolide, an effective agent against oxidative damage, apoptosis and autophagy in the ovarian torsion/detorsion model.

Aim: This study assessed the efficacy of costunolide (COST) against oxidative tissue damage in the ovarian torsion/detorsion (TD) model.

Methodology: Animals were randomly assigned to sham, ovarian TD, COST 5 mg/kg + ovarian TD, and COST 10 mg/kg + ovarian TD groups. COST's effectiveness was determined by assessing oxidative stress markers, interleukin levels, and histopathological examinations.