Morphometric Assessment of Temporomandibular Joint Space in Dentate and Edentulous Patients by Using Cone Beam Computed Tomography.

Aim: This study aimed to determine the changes in the temporomandibular joint due to ethnicity and to reveal gender differences.

Methods: This retrospective study included the evaluation of cone beam computed tomography (CBCT) images of 110 patients (220 temporomandibular joint {TMJs}), 64 dentulous (32 females, 32 males) and 46 edentulous (18 females, 28 males). Anterior, superior, and posterior joint spaces and the roof of the glenoid fossa (GF) were measured in sagittal views.

Cross-protection of AIT-induced antibodies to related allergens requires a high degree of structural identity.

Background: In contrast to sublingual immunotherapy (SLIT) with recombinant Mal d 1 (rMal d 1-SLIT), SLIT with rBet v 1 (rBet v 1-SLIT) induced Mal d 1-cross-reactive antibodies without IgE-blocking activity. To elucidate whether the development of cross-protective IgG responses depends on the degree of molecular identity of allergens we compared the cross-reactivity, cross-blocking activity, and affinity of SLIT-induced antibodies with allergens of varying amino acid sequence identities to Bet v 1 and Mal d 1, namely Cor a 1.04 (hazelnut), Pru av 1 (cherry), and Dau c 1 (carrot).

Easy assessment of the avidity of polyclonal allergen-specific serum antibodies.

Introduction: Allergen-specific IgE-blocking IgG antibodies contribute to successful allergen immunotherapy (AIT), however, not much is known about their affinity. Since affinity measurements of polyclonal antibodies in serum are technically challenging we evaluated the applicability of acidic disruption of antibody-allergen complexes by a modified ELISA protocol with monoclonal antibodies (mAbs) specific for the relevant major allergens Betv1 and Mald1. Then, AIT-induced blocking and non-blocking Mald1-specific antibodies in sera from individuals with or without reduced apple allergy were compared.

The role of IgG and IgG as dominant IgE-blocking antibodies shifts during allergen immunotherapy.

Background: The induction of allergen-specific IgE-blocking antibodies is a hallmark of allergen immunotherapy (AIT). The inhibitory bioactivity has largely been attributed to IgG; however, our recent studies indicated the dominance of IgG early in AIT.

Objectives: Here, the IgE-blocking activity and avidity of allergen-specific IgG and IgG antibodies were monitored throughout 3 years of treatment.

Identification of apple cultivars hypoallergenic for birch pollen-allergic individuals by a multidisciplinary in vitro and in vivo approach.

Background: Birch pollen-related apple allergy is the most frequent IgE-mediated food allergy in Central-Northern Europe with Mal d 1 as major allergen. Its concentration in apples varies with the cultivar and storage time. Year-round appealing, hypoallergenic cultivars still are needed to satisfy the nutritional needs of affected individuals.

Diagnostic accuracy of panoramic radiography and ultrasonography in detecting periapical lesions using periapical radiography as a gold standard.

Objectives: The purpose of this study was to compare the accuracy of imaging techniques in diagnosing periapical lesions.

Methods: Imaging records of 80 patients (51 females, 29 males, aged between 14 and 75 years) including periapical and panoramic radiographs and ultrasonographic images were selected from databases of Selcuk University Dentistry Faculty. Periapical radiographs were accepted as gold-standard and 160 anterior maxillary and mandibular teeth with or without periapical lesion were included to the study.

[Lingual schwannoma].

Schwannomas are benign, slow growing, solitary and encapsulated neuroectodermal tumors arising from Schwann cells of the nerve sheath. Twenty-five percent of all extracranial schwannomas are seen in the head and neck region. Intra-oral schwannomas are rare and commonly seen at the tongue base.