Nuclear Astrophysics in the Storage Ring: Background Suppressed Simultaneous Measurement of (p,γ) and (p,n) Reactions.

We report the application of the new elimination of Rutherford elastic scattering technique for the measurement of proton-induced reaction cross sections utilizing stored ions decelerated to astrophysical energies. This approach results in a background reduction factor of about 1 order of magnitude, enabling the first measurement of a (p, n) cross section in a storage ring. Here, the reaction channels ^{124}Xe(p,n) and ^{124}Xe(p,γ) have been studied just above the neutron threshold energy.

A ″On-Off″ Fluorescent Sensor Based on Coumarin-Furoic Hydrazide for Recognition of Fe: Drinking Water, Test Strip Applications and DFT Calculations.

A coumarin based fluorescent probe (E)-N'-((7-hydroxy-2-oxo-2H-chromon-3-yl)methylene)furan-2-carbohydrazide (CFHZ) was synthesized for the detection of Fe and its characterizations were carried out using spectroscopic methods such as FT-IR, mass spectrometryH-NMR, C-NMR. The novel probe CFHZ showed a highly selective and sensitive "turn-off" response to Fe ion without any interference from other analytes. Strong fuorescence quenching phenomena of the CFHZ were observed in EtOH:HO (99/1, v/v) detection system (λ = 470 nm) upon the additions of Fe.

Meteorin-like levels of oral fluids in periodontal health and diseases: a comparative cross-sectional study.

Objectives: Cytokines are critical role in the pathogenesis of periodontal diseases. Meteorin-like (Metrnl), a protein released in the oral mucosa, is a novel cytokine associated with various inflammatory diseases. This study aimed to evaluate levels of salivary and gingival crevicular fluid (GCF), interleukin - 1 beta (IL-1β), interleukin - 10 (IL-10), and Metrnl in periodontal disease.

The pantothenic acid derivative dexpanthenol ameliorated doxorubicin-induced neurotoxicity via regulating AKT/CREB/BDNF and AKT/NRF2 signaling pathways.

Background: Doxorubicin (Dox)-induced neurotoxicity is a well-documented side effect of chemotherapy. Dexpanthenol (Dex), an analog of vitamin B5, has shown protective properties. This study aimed to explore the molecular mechanisms by which Dex mitigates Dox-induced neurotoxicity, particularly through the protein kinase B (AKT)/cyclic AMP-response element-binding protein (CREB)/brain-derived neurotrophic factor (BDNF) pathway and nuclear factor erythroid 2-related factor 2 (NRF2) signaling.

Evaluation of sarcopenia's relationship with overall survival and treatment toxicity in soft tissue sarcomas.

Aim: The aim of our study is to evaluate the relationship between sarcopenia, overall survival (OS), and chemotherapy toxicity in patients with unresectable/metastatic soft tissue sarcoma (STS) treated with adriamycin and ifosfamide.

Methods: Patients with unresectable/metastatic STS over the age of 18, diagnosed between 2015 and 2023, were included in the study. The study was conducted retrospectively in a single center.

Gamma Decay of the ^{154}Sm Isovector Giant Dipole Resonance: Smekal-Raman Scattering as a Novel Probe of Nuclear Ground-State Deformation.

γ decays of the isovector giant dipole resonance (IVGDR) of the deformed nucleus ^{154}Sm were measured using 2_{1}^{+}-Smekal-Raman and elastic scattering of linearly polarized, quasimonochromatic photon beams. The two scattering processes were disentangled through their distinct angular distributions. Their branching ratio and cross sections were determined at six excitation energies covering the ^{154}Sm IVGDR.

Protective effect of dapagliflozin on lipopolysaccharide-induced acute lung injury via the SIRT-1/PGC-1α pathway.

Background: Acute systemic inflammation affects many organs and it occurs in a wide range of conditions such as acute lung injury (ALI). Inflammation-triggered oxidative pathways together with the caspase activation seen in ALI, result in apoptosis. Dapagliflozin (DPG) is an agent that is known to have oxidative stress-reducing and anti-inflammatory effects in many tissues.

Effects of Tasimelteon Treatment on Traumatic Brain Injury Through NRF-2/HO-1 and RIPK1/RIPK3/MLKL Pathways in Rats.

Secondary brain damageafter traumatic brain injury (TBI) involves oxidative stress, neuroinflammation, apoptosis, and necroptosis and can be reversed by understanding these molecular pathways. The objective of this study was to examine the impact of tasimelteon (Tasi) administration on brain injury through the nuclear factor erythroid 2-related factor 2 (NRF-2)/heme oxygenase-1 (HO-1) and receptor-interacting protein kinase 1 (RIPK1)/receptor-interacting protein kinase 3 (RIPK3)/mixed lineage kinase domain-like (MLKL) pathways in rats with TBI. Thirty-two male Wistar albino rats weighing 300-350 g were randomly divided into four groups: the control group, trauma group, Tasi-1 group (trauma + 1 mg/kg Tasi intraperitoneally), and Tasi-10 group (trauma + 10 mg/kg Tasi intraperitoneally).

Predictive factors for drainage in pediatric cervical lymphadenitis: A study of clinical indicators and recovery outcomes.

Background: The purpose of this study was to investigate the predictive factors for drainage in patients hospitalized with cervical lymphadenitis in the Pediatrics Infectious Diseases Department and to differentiate the recovery time between patients who received antibiotic treatment only and those who received drainage for their lymphadenitis.

Materials And Methods: We retrospectively analyzed 169 patients selected for this study, aged 1 month to 18 years, who were followed up with a diagnosis of cervical lymphadenitis between January 2011 and December 2019. Clinical features such as sex, age, physical examination findings, laboratory findings, imaging findings, and antibiotic treatments were retrospectively reviewed.

Treatment Effectiveness of Volar Plates in Distal Radius Dorsal Rim Fractures.

 To assess the efficacy of distal radius volar plates in cases involving dorsal fragments at the Ulnar Corner (UC) and Lister Tubercle (LT).  A retrospective study that included patients with distal radius fractures (DRFs) featuring UC and LT dorsal fragments treated with volar plates. The exclusion criteria comprised lunate facet fractures, UC fragment ratio below 25%, and patients treated with dorsal plates.

Long-Term Outcome of Childhood Asthma: Characterizing COPD-A and COPD-C Subtypes in Adulthood.

Background And Aim: Asthma in early life has been linked to subsequent development of COPD and according to GOLD 2023 COPD may be divided into distinct subtypes. We aimed to investigate factors associated with the GOLD classification COPD-A (asthma in childhood) and COPD-C (tobacco exposure) in a cohort of adults with a history of severe childhood asthma.

Patients And Methods: In a cohort of Danish adults with a history of severe childhood asthma and a previous 4-month stay during childhood at the asthma care facility in Kongsberg, Norway, we divided participants in a long-term follow-up examination into COPD-A and COPD-C, defined as post-bronchodilator FEV/FVC < 0.

Evaluation of cytoprotective effects of cannabidiol on neuroinflammation and neurogenesis process in rat offsprings.

Natural compounds include complex chemical compounds that exist in plants, animals and microbes. Due to their broad spectrum of pharmacological and biochemical actions, they have been widely used to treat multifactorial diseases, including cancer. In addition, their demonstrated neuroprotective properties strongly support their use in the treatment of neurological diseases.

Cannabidiol mitigates methotrexate-induced hepatic injury via SIRT-1/p53 signaling and mitochondrial pathways: reduces oxidative stress and inflammation.

Methotrexate (MTX), a widely used chemotherapeutic agent, often induces hepatotoxicity, limiting its clinical utility. Cannabidiol (CBD), derived from hemp, possesses antioxidant, anti-inflammatory, and antiapoptotic properties. This study aims to investigate CBD's protective effects against MTX-induced liver injury and elucidate the underlying mechanisms.

YouTube as a source of information in cardiopulmonary resuscitation for 2020 AHA Resuscitation Guidelines.

Background: The Internet has transformed global information access, particularly through platforms like YouTube, which launched in 1995 and has since become the second largest search engine worldwide with over two billion monthly users. While YouTube offers extensive educational content, including health topics like cardiopulmonary resuscitation (CPR) and basic life support (BLS), it also poses risks due to potential misinformation. Our study focuses on evaluating the accuracy of CPR and BLS videos on YouTube according to the latest 2020 American Heart Association (AHA) guidelines.

Meningiomas: Sex-Specific Differences and Prognostic Implications of a Chromosome X Loss.

Background: Meningiomas are the most common primary intracranial tumours in adults. Several studies proposed new stratification systems with a more accurate risk prediction than the WHO grading, e.g.

FGF-2 enriched nanofiber scaffold for advancing achilles tendon healing: a comparative experimental investigation.

Introduction: Achilles tendon rupture is a common and debilitating injury that significantly impacts mobility and quality of life. Effective treatment options that promote faster and more complete healing are needed. Fibroblast growth factor-2 (FGF-2) has shown potential in enhancing tendon repair.

A saturation based self-tuned robust control design for Euler Lagrange systems.

Control of the family of systems that can be represented in the Euler Lagrange (EL) form is both challenging from a theoretical perspective and applicable to a broad spectrum of real systems. For this type of control problem, given that any parameter estimation error and disturbances are not directly addressed, the system performance deteriorates, and stability cannot be deduced in advance. Considering these issues, this work presents the design and the corresponding analysis of a saturation function based, model-free, continuous robust controller for mechanical systems represented in the EL form.

Socioeconomic status and emergency department visits in adults with a history of severe childhood asthma: a register-based study.

Background And Objective: Our knowledge of socioeconomic status (SES) and emergency department (ED) visits in adults with a history of severe childhood asthma is limited. Our aim was, therefore, to investigate these variables in individuals with a history of severe childhood asthma compared to a control population.

Methods: The Kongsberg cohort comprises Danish individuals with a history of severe childhood asthma and a previous 4-month stay at an asthma care facility in Kongsberg, Norway, between 1950 and 1979.

Energy-Efficient Anomaly Detection and Chaoticity in Electric Vehicle Driving Behavior.

Detection of abnormal situations in mobile systems not only provides predictions about risky situations but also has the potential to increase energy efficiency. In this study, two real-world drives of a battery electric vehicle and unsupervised hybrid anomaly detection approaches were developed. The anomaly detection performances of hybrid models created with the combination of Long Short-Term Memory (LSTM)-Autoencoder, the Local Outlier Factor (LOF), and the Mahalanobis distance were evaluated with the silhouette score, Davies-Bouldin index, and Calinski-Harabasz index, and the potential energy recovery rates were also determined.

Clinical effects of omega-3 fatty acids supplementation in the periodontal treatment of smokers and non-smokers with periodontitis: a retrospective study.

Objectives: Omega-3 supplementation as an adjunct to nonsurgical periodontal treatment has been reported to have a positive effect on healing in periodontitis patients. However, there is a lack of information on the effects of periodontal healing in smokers with periodontitis. The aim of this retrospective study was to investigate the effect of omega-3 supplementation given as an adjunct to nonsurgical periodontal treatment on clinical parameters in smoker and non-smoker periodontitis patients.

Characteristics of Adults With Severe Asthma in Childhood: A 60-Year Follow-Up Study.

Background: Childhood asthma is a prevalent condition with potential impacts on adult life.

Research Question: In a 60-year follow-up study of adults with a history of severe childhood asthma, what are the potential differences in characteristics between individuals with persistent asthma and asthma remission in adulthood?

Study Design And Methods: Danish adults with a history of childhood asthma and a 4-month stay at an asthma care facility in Kongsberg, Norway (1950-1979) in childhood were included. Recruitment was carried out through social media and personal invitation letters.

A randomized controlled trial of Eye Movement Desensitization and Reprocessing (EMDR) Therapy in the treatment of fibromyalgia.

Background: In addition to pharmacological treatment, psychotherapeutic approaches are recommended for the treatment of fibromyalgia. There is a suggestion that eye movement desensitization and reprocessing (EMDR) therapy may be effective. This study aimed to investigate the impact of EMDR therapy on fibromyalgia symptoms, depression, sleep quality, and traumatic stress in fibromyalgia patients through a randomized controlled study (RCT).