Publications by authors named "Guelcim Saracoglu"

Background: Seborrheic dermatitis (SD) is a chronic, inflammatory disease characterized by unknown etiopathogenesis. It affects skin areas rich in sebaceous glands. There are strong data on the relationship between nutrition habits, body mass index (BMI), psychoemotional status, and sebaceous gland diseases such as acne, rosacea, and androgenetic alopecia.

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Purpose: This study aimed to investigate the effectiveness of Manual Lymphatic Drainage (MLD) on the pain intensity, impact of the disease, and health-related quality of life among women diagnosed with Fibromyalgia syndrome (FMS).

Methods: The study was designed as a single-center, double-blind, randomized, and sham-controlled trial. Twenty women with FMS were included and randomized into intervention ( = 11) and sham control ( = 9) groups.

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Laparoscopic sleeve gastrectomy is a restrictive surgery that aims to decrease the gastric volume of the patient. This study hypothesized that a higher resected gastric volume to the number of fired staplers ratio is associated with improved postoperative 12th-month outcomes. To analyze the effects of resected gastric volume to the number of fired staplers ratio on postoperative results in patients who underwent sleeve gastrectomy.

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Background: Understanding the financial burden of smoking on households is crucial for developing effective strategies and policies to reduce smoking and mitigate its impact on household health.

Aim: To investigate the relationship between smoking and catastrophic health expenditure in Türkiye.

Methods: This cross-sectional study used microdata from household budget surveys conducted by the Turkish Statistical Institute in 2015 and 2019.

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Ulexite (UX), a naturally occurring borate mineral, has gained interest for its diverse industrial applications, yet its toxicological profile remains inadequately characterized. This study aimed to evaluate the subacute toxicity of UX in rats, focusing on behavioral, hematological, and biochemical parameters. Rats were administered UX via gavage at doses of 10, 30, and 300 mg/kg for 7 days.

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Refractory status epilepticus (RSE) is a condition with serious mortality and morbidity rate, resistant to benzodiazepine and second-line antiepileptic drugs. This study aimed to electrophysiologically investigate the combination of NMDA receptor antagonist ketamine and GABAergic agent propofol in an RSE model induced by lithium-pilocarpine in male Sprague-Dawley rats. Seventy-two male Sprague-Dawley rats were divided into nine groups.

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Article Synopsis
  • - The study aimed to assess the effectiveness of the Integrated Pulmonary Index (IPI) in monitoring patients during EBUS-TBNA procedures under sedation, specifically looking at its impact on hypoxic events compared to traditional monitoring.
  • - Conducted at Dr. Lutfi Kirdar City Hospital in Istanbul, the study involved 50 patients and measured IPI values at different stages, revealing that patients with higher IPI scores experienced fewer apnea incidents and better respiratory metrics.
  • - The findings suggest that IPI monitoring enhances the detection of apnea and improves respiratory safety during procedures, but further research is needed with diverse patient groups to validate these outcomes.
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The synthesis of 5-aryl- or 5,6-diaryl-11-benzo[]carbazoles has been achieved from 3-styryl indoles through catalyst-free photoinitiated dehydrogenative cyclization transformation, providing a range of structurally diverse products in excellent yields under mild conditions. The protocol is also applicable to furan and thiophene samples. This Mallory-type reaction takes place in an argon atmosphere without external oxidants.

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  • Prurigo nodularis is a chronic skin condition that leads to intense itching, and narrowband-UVB (NB-UVB) phototherapy is a potential treatment, especially for patients with other health issues.
  • In a study involving 30 patients, NB-UVB therapy resulted in complete response (80%) or partial response (20%) to treatment, with better outcomes for those with diffuse and central lesions.
  • The study highlights the effectiveness and safety of NB-UVB for treating prurigo nodularis, but acknowledges its limitations, such as being conducted at a single center and having a retrospective design.
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  • * The Infrared Fluorescent Angiography Perfusion Evaluation Device (SPY) is a noninvasive tool used to assess microcirculation and perfusion in flaps during surgery.
  • * A study involving 39 patients analyzed the relationship between fluid resuscitation during head and neck free flap surgery and patient outcomes, finding that changes in SPY scores were linked to longer hospital stays and additional medical interventions.
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Introduction: Generalized granuloma annulare (GA) is an uncommon noninfectious granulomatous dermatitis. Phototherapy is often considered first-line therapy, with more evidence for psoralen ultraviolet A than narrowband ultraviolet B (NB-UVB). We aimed to evaluate the effectiveness and safety of NB-UVB in generalized GA and to review the literature.

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Objectives: To determine the phenotypes of chronic pain seen in individuals caring for children with cerebral palsy (CP).

Methods: A current classification system was used to determine the prevalence of predominant pain phenotypes in caregivers of children with CP. To this end, the Visual Analog Scale, Margolis pain diagram, Central Sensitization Inventory, and Short Form-36 questionnaire were administered to the participants.

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  • The study investigates the effectiveness of the Oxygen Reserve Index (ORI™) as a noninvasive early predictor of hypoxemia during minimally invasive pectus excavatum repair (MIRPE) in children aged 8-18 years.
  • In a controlled trial with 128 participants, the ORI group showed a significantly shorter desaturation time (about 59 seconds) compared to the control group's pulse oximetry (about 178 seconds), indicating faster hypoxemia detection.
  • The findings suggest that ORI monitoring can enhance patient safety by reducing exposure to high oxygen levels and shortening hospital stays following MIRPE surgery.
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Objective: The aim of this study was to determine the effectiveness of a virtual service/patient-based program (vSPBP) developed for nursing education and its effect on the development of care plan preparation and clinical decision-making skills.

Methods: The study was conducted in a quasi-experimental design with a sample of fourth-year nursing students. Participants were assigned to the intervention group (n=44) and control group (n=51).

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Article Synopsis
  • - The study focuses on evaluating the effectiveness of a new monitoring parameter, ORi, for detecting hypoxia in morbidly obese patients undergoing elective surgery, especially compared to the standard pulse oximetry (SpO).
  • - Conducted in a tertiary hospital, the observational study included 102 patients categorized by BMI and monitored their oxygen saturation during the surgical procedure, recording various critical time points for both ORi and SpO.
  • - Results showed that morbidly obese patients had a faster rate of oxygen recovery with ORi (32 seconds) compared to non-obese patients (94 seconds), indicating that ORi may provide quicker alerts for hypoxia compared to traditional SpO methods.
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Background: The aim of this study was to investigate the potential association between vitamin D deficiency and matrix metalloproteinase-9 (MMP-9) levels in gingival crevicular fluid (GCF) across various periodontal health and disease statuses.

Methods: A total of 200 volunteers were divided into two groups according to serum vitamin D concentration (25(OH)D < 10 ng/mL and 25(OH)D ≥ 10 ng/mL). Periodontal health status was determined based on a full-mouth periodontal examination and radiographic evaluation.

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Aim: Attitude is a response to certain events and phenomena based on past knowledge and experience. This study aimed to improve the attitudes of family members toward diabetes after the implementation of the program.

Method: The study was a one-group quasi-experimental design conducted with family members of patients with diabetes in a city in northern Turkey.

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Purpose: Major depressive disorder (MDD) is a complex condition believed to arise from a multifaceted interplay of genetic, environmental, and biological factors. In the pursuit of understanding its etiology, two elements that warrant investigation are borderline personality disorder (BPD) and affective temperaments. We aim to gain deeper insights into the mechanisms underlying this debilitating mental health condition.

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The primary objective of this in vitro study was to prevent the risk of toxicity associated with bupivacaine, widely used in clinical practice, by using magnesium (Mg), a readily available and cost-effective element, as an adjuvant. We hypothesized that Mg might exhibit a protective effect against cytotoxicity in a colon cell culture model under conditions of bupivacaine-induced LAST. Our secondary aim was to investigate its effect on genotoxicity, apoptosis, and iROS.

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Terminal ileal ulcers can have various etiologies, including Crohn's disease (CD), infections, and medication-related causes. This study aims to investigate the incidence of terminal ileal ulcers detected during colonoscopies, explore their underlying causes, and analyze their clinical, endoscopic, and histopathological characteristics. Additionally, the study aims to identify predictive factors that indicate the need for follow-up.

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Objective:  Coronavirus disease 2019 (COVID-19) caused morbidity and mortality worldwide. Besides the acute effects, subacute and long-term effects are defined as long-COVID causing morbidity. The intensive care unit (ICU) data of long-COVID-19 cases were evaluated with the participation of 11 centers.

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A real-time hypothermia and hyperthermia monitoring system with a simple body sensor based on a Convolutional Neural Network (CNN) is presented. The sensor is produced with 3D-printed thermochromic material. Due to the color change feature of thermochromic materials with temperature, 3D-printed thermochromic Polylactic Acid (PLA) material was used to monitor temperature changes visually.

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Aim: To evaluate the effects of tramadol on inflammation by measuring NLRP1 and IL-1 beta (IL-1β) levels in an experimental neuropathic pain model.

Material And Methods: Sprague-Dawley rats were divided into three groups: control, chronic constriction injury (CCI), and CCI + tramadol. Neuropathic pain was assessed using mechanical allodynia, thermal hyperalgesia, and cold allodynia.

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The increased use of dietary supplements is a consequence of the coronavirus disease 2019 (COVID-19) pandemic. Although their efficacy has not been consistently proven, they have been perceived as a preventive tool against COVID-19. Less strict regulations and debates on their definitions in a regulatory framework raise concerns about safety issues.

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Background: Medical emergency complications may occur during dermatological, surgical, and cosmetic procedures.

Aims: This study aimed to investigate the frequency of dermatologists who experienced emergency complications as well as their level of knowledge regarding emergencies and basic life support.

Methods: The cross-sectional descriptive study was conducted online among 240 dermatologists to whom a questionnaire was sent via email and a closed social media group.

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