Expanding the genotypic spectrum of 3β-hydroxy-δ5-C27-steroid dehydrogenase (HSD3B7) deficiency: novel mutations and clinical outcomes.

Objectives: HSD3B7 deficiency is a genetic disorder caused by mutations in the gene, leading to impaired bile acid synthesis and the accumulation of toxic intermediates. Affected patients typically present with cholestatic liver disease, including jaundice and progressive liver dysfunction.

Case Presentation: This case series describes three pediatric patients from two families diagnosed with HSD3B7 deficiency, each demonstrating varying clinical severity and outcomes.

The effect of the COVID-19 pandemic on clinical and pathologic stages of patients diagnosed with breast cancer.

Aim: This study aimed to investigate the effect of the COVID-19 pandemic on the clinical and pathological stages of patients diagnosed with breast cancer.

Method: In this retrospective study, a total of 298 male and female patients over the age of 18 who were diagnosed with breast cancer and who were continuing surgical and oncologic treatment were included.

Results: Of the 298 patients diagnosed with breast cancer, 186 (62.

Digital media use and its effects on digital eye strain and sleep quality in adolescents: A new emerging epidemic?

This study examines the association between excessive digital media use and adverse health outcomes, specifically Digital Eye Strain (DES) and Poor Sleep Quality (PSQ), in adolescents. A cross-sectional survey of 512 participants (aged 11-18 years) assessed DES and PSQ using the Computer Vision Syndrome Questionnaire and the Pittsburgh Sleep Quality Index. We found a high prevalence of DES (63.

Microstructural Changes in Intraretinal Layers and Macular Structures of People with Epilepsy Measured Using Optical Coherence Tomography.

Introduction: Epilepsy is a network disorder that can cause alterations in retinal morphology due to microstructural changes in the brain. The aim of our study was to use spectral optical coherence tomography (OCT) to assess the possible effects of neuronal degeneration on the intraretinal layers and macular structures of people with epilepsy and epilepsy subgroups.

Methods: We enrolled 52 consecutive people with epilepsy (37 females, 15 males; mean age 29.

A Pilot Study Investigating the Feasibility, Reach-Out, Acceptability, Fidelity, and Efficacy of a Group Laughie Prescription on the Well-Being of Earthquake Survivors in Türkiye.

Mental health and quality of life may be negatively impacted among earthquake survivors. This pilot study evaluates the use of and reports on the preliminary effects of participating in a 1-minute Laughie (Laugh Intentionally Everyday) Laughter Prescription on well-being in earthquake survivors in Türkiye. A Group Laughie intervention was delivered using a within-subject ( = 20; M age = 34.

Exploring gastrointestinal manifestations in childhood onset systemic lupus erythematosus - Insights from a multicenter study.

Objective: Systemic lupus erythematosus (SLE) constitutes an autoimmune disorder with potential involvement of the gastrointestinal system (GIS). Our objective was to assess the gastrointestinal (GI) manifestations in patients diagnosed with childhood onset SLE.

Methods: The study cohort consisted of 123 patients with childhood onset-SLE and GIS involvement from 16 referral departments of pediatric rheumatology.

Meta-heuristic optimization algorithms based feature selection for joint moment prediction of sit-to-stand movement using machine learning algorithms.

The sit-to-stand (STS) movement is fundamental in daily activities, involving coordinated motion of the lower extremities and trunk, which leads to the generation of joint moments based on joint angles and limb properties. Traditional methods for determining joint moments often involve sensors or complex mathematical approaches, posing limitations in terms of movement restrictions or expertise requirements. Machine learning (ML) algorithms have emerged as promising tools for joint moment estimation, but the challenge lies in efficiently selecting relevant features from diverse datasets, especially in clinical research settings.

Automated classification of choroidal neovascularization, diabetic macular edema, and drusen from retinal OCT images using vision transformers: a comparative study.

Classifying retinal diseases is a complex problem because the early problematic areas of retinal disorders are quite small and conservative. In recent years, Transformer architectures have been successfully applied to solve various retinal related health problems. Age-related macular degeneration (AMD) and diabetic macular edema (DME), two prevalent retinal diseases, can cause partial or total blindness.

Retinal Tear Following Low-Frequency Repetitive Transcranial Magnetic Stimulation for Obsessive-Compulsive Disorder.

Objectives: Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive form of brain stimulation that uses magnetic pulses to stimulate specific brain regions. Retina is being investigated whether the retina, which is also known as the brain's window to the outside world, is affected by the treatment.

Methods: Magventure X100 device was used for the procedure.

COMPARISON OF THE EFFECTS OF EIGHT DIFFERENT TOPICAL NONSTEROIDAL ANTI-INFLAMMATORY DRUGS ON REDUCING INTRAVITREAL INJECTION-INDUCED PAIN.

Purpose: To compare topical nonsteroidal anti-inflammatory drug (NSAID) efficacy on intravitreal injection-induced pain reduction and determine the most efficient topical NSAID.

Methods: This randomized-controlled study included 662 eyes of 662 patients. Based on the types of NSAID administered before intravitreal injection, eight subgroups were formed.

University makes me angry: Investigating stimulus-response (S-R) and cognitive-mediation (C-M) emotion beliefs in undergraduate students.

Emotion regulation through cognitive reappraisal is well-studied, but less so are the predispositional and superordinate beliefs that influence reappraisal. Recently, researchers developed the cognitive mediation beliefs questionnaire (CMBQ), which measures two emotion beliefs, namely stimulus-response (S-R) generation beliefs and cognitive mediation (C-M) change beliefs. In working populations S-R generation beliefs are inversely related to cognitive reappraisal tendencies and positive mental health, and positively related to emotion reactivity.

The hidden pandemic: a qualitative study on how middle-aged women make sense of managing their long COVID symptoms.

Background: A relapsing and remitting illness, long COVID can be challenging and debilitating. A person living with long COVID can feel like they are getting better and recovering only to relapse again. The aim of the research was to explore how non-hospitalized middle-aged women who contracted COVID in the first wave of the pandemic, from March 2020, are managing their long COVID symptoms.

The Relationship Between the Sense of Professional Belonging and Perceptions of Spirituality and Spiritual Care Among Turkish Midwifery Students.

This study examined the relationship between the sense of professional belonging and perceptions of spirituality and spiritual care among midwifery students. This cross-sectional study's sample included 194 third- and fourth-year midwifery students associated with the Faculty of Health Sciences at two universities in western Turkey. Data were collected using web-based surveys.

Exploring long-term responses to immune checkpoint inhibitors in recurrent and metastatic head and neck squamous cell carcinoma.

Objectives: Immune checkpoint inhibitors (ICI) have introduced a new era in the treatment of recurrent and/or metastatic head and neck squamous cell carcinoma (R/M HNSCC). Optimal duration for ICI therapy is still unclear and the long-term outcomes and toxicity in patients responding to these therapies warrant further exploration. This study attempts to identify the clinical and biological determinants of a durable response and evaluate outcomes following ICI treatment discontinuation.

'Turbulence even in a bubble': a reflexive thematic analysis with family caregivers of people with dementia in the United Kingdom during and beyond the COVID-19 pandemic.

Objective: This study aimed to understand how family caregivers of people with dementia managed changes caused by COVID-19 restrictions and how they adjusted to the lifting of restrictions. A particular focus of the study was on understanding the impact of social isolation, a reduction of social interactions, and reduced access to healthcare services.

Methods And Measures: Fourteen voluntary caregivers (nine women) were interviewed using a semi-structured interview schedule.

Accuracy of Different Lens Power Calculation Formulas in Patients With Mature Cataracts.

Introduction To compare the prediction accuracy of lens power calculation formulas in patients undergoing mature cataract surgery. Methods A total of 90 operations involving the Alcon SA60AT IOL implant (Alcon, Geneva, Switzerland) were analyzed in terms of mean refractive prediction error (PE) and mean absolute prediction error (MAE) using backward calculation in a retrospective design. Results A negative PE was observed in SRK/T, Holladay 1, Holladay 2, Hoffer Q, Haigis, and Emmetropia Verifying Optical (EVO) formulas.

Can surgically assisted rapid palatal expansion (SARPE) be recommended over orthodontic rapid palatal expansion (ORPE) for girls above the age of 14? : A cone-beam CT study on midpalatal suture maturation.

Background: For patients with a maxillary transversal deficiency (MTD), various treatment options are available, partly based on the practitioner's experience. This study aimed to determine a cut-off age for decision making between surgically assisted rapid palatal expansion (SARPE) over orthodontic rapid palatal expansion (ORPE) based on skeletal maturation in a female population.

Methods: A total of 100 cone beam computed tomography (CBCT) images of young females were analyzed on maturation of the pterygomaxillary (PMS), zygomaticomaxillary (ZMS), transpalatal (TPS), and midpalatal (MPS) sutures.

The role of inflammatory biomarkers in predicting primary acquired nasolacrimal duct obstruction and postoperative recurrence.

This study aims to determine the relationship between systemic inflammatory biomarkers and primary acquired nasolacrimal duct obstruction and to evaluate whether they can be used as indicators in determining the risk of recurrence after dacryocystorhinostomy. This retrospective, comparative case series was conducted with 57 primary acquired nasolacrimal duct obstruction patients and 58 age- and gender-matched controls. All subjects underwent a complete ophthalmologic examination and complete blood count measurements.

A comparative analysis of meta-heuristic optimization algorithms for feature selection on ML-based classification of heart-related diseases.

This study aims to use a machine learning (ML)-based enhanced diagnosis and survival model to predict heart disease and survival in heart failure by combining the cuckoo search (CS), flower pollination algorithm (FPA), whale optimization algorithm (WOA), and Harris hawks optimization (HHO) algorithms, which are meta-heuristic feature selection algorithms. To achieve this, experiments are conducted on the Cleveland heart disease dataset and the heart failure dataset collected from the Faisalabad Institute of Cardiology published at UCI. CS, FPA, WOA, and HHO algorithms for feature selection are applied for different population sizes and are realized based on the best fitness values.

Safety and efficacy of adjunctive therapy in the treatment of odontogenic keratocyst: a systematic review.

The odontogenic keratocyst (OKC) is a common cystic lesion in the jaw. Its management, however, is highly debated with no consensus on the best treatment option. Clinicians base their approach on treatment efficacy and associated morbidity.

Risk of medication-related osteonecrosis of the jaw after dental extractions in patients receiving antiresorptive agents - A retrospective study of 240 patients.

This study investigated the incidence, risk factors, and outcome of medication-related osteonecrosis of the jaw after dental extractions in patients receiving antiresorptive agents for osteoporosis or bone metastases. 240 patients with a median drug exposure of 43 months were retrospectively studied. The incidence of MRONJ after dental extraction in the osteoporosis cohort was 2.

Changes in intra-ocular pressure, ocular pulse amplitude and choroidal thickness after trabeculectomy.

Clinical Relevance: Glaucoma is one of the most common causes of blindness. Although high intra-ocular pressure (IOP) is the most important risk factor, ocular blood flow also has an effect on prognosis.

Background: The aim of this study was to investigate the IOP, ocular pulse amplitude (OPA) and choroidal thickness (CT) changes after trabeculectomy and to determine whether trabeculectomy has an effect on ocular blood flow.

Compound impacts from droughts and structural vulnerability on human mobility.

Extreme dry events already disrupt populations' ability to migrate. In a warming climate, compound drought events could amplify vulnerability and drive forced migration. Here, we contribute the first multi-method research design on societal impacts from compound drought events.