Protective Effects of Bosentan via Endothelin Receptor Antagonism in Experimental Ischemia-Reperfusion Injury in the Lower Limb of Rats.

Objective: This study aimed to evaluate the protective effects of bosentan, a dual endothelin receptor antagonist, against skeletal muscle ischemia-reperfusion injury (IRI) in rats.

Methods: A total of 24 male Wistar Albino rats were divided into four groups: control (C, n=6), bosentan-treated (B, n=6), ischemia-reperfusion (IR, n=6), and bosentan plus ischemia-reperfusion (B+IR, n=6). Bosentan (10 mg/kg) was administered 30 minutes prior to reperfusion.

Effects of exercise in primary Sjögren's syndrome: a systematic review and meta-analysis of randomized clinical trials.

Purpose: To systematically review the effects of exercise interventions on pain, fatigue, quality of life, disease activity, aerobic capacity, and dryness in primary Sjögren's syndrome (pSS), and to determine the most effective type of exercise.

Materials And Methods: A literature search was conducted using Web of Science, PubMed/MEDLINE, ProQuest, SCOPUS, Cochrane Library, and PEDro databases. Randomized clinical trials (RCTs) examining the effects of exercise interventions in patients with pSS were included.

Analysis of proinflammatory cytokine responses in Takayasu arteritis.

Objectives: This study aimed to investigate the expression of proinflammatory cytokines under long-term T helper (Th) 17 cell inducing conditions in Takayasu arteritis (TAK), a granulomatous vasculitis with adaptive immune responses.

Patients And Methods: This cross-sectional study was conducted between May 2014 and April 2017. Peripheral blood mononuclear cells from 25 patients (23 females, 2 males; mean age: 42.

Do the azo food colorings carmoisine and ponceau 4R have a genotoxic potential?

Today, ready-to-eat foods to which various additives are frequently added are widely consumed. Food colorings constitute an essential part of these additives. Carmoisine (E-122) and Ponceau 4R (E-124) are the most commonly used azo food colorings.

First detection and molecular characterization of Chaphamaparvovirus galliform in broiler and turkey flocks in Türkiye.

Background: A newly uncovered parvovirus, Chaphamaparvovirus, continues to be reported across various species. This study investigated the detection and genetic characterization of Chaphamaparvovirus galliform (GaChpV) in poultry, specifically broilers and turkeys, from various regions in Türkiye. To address this, comprehensive sampling and analysis were conducted to better understand the virus's distribution and impact in these avian populations.

Assessing the qualities of sleep and life for menopausal women after the February 6 earthquake.

Earthquakes can cause significant changes in the qualities of sleep and life of menopausal women. The aim of this study is to determine the qualities of sleep and life of menopausal women after the earthquake. This cross-sectional and correlational study was conducted with 182 menopausal women who applied to the State Hospital between 24 June and 14 September 2023.

Bilateral inferior colliculus infarction after embolization of a cerebellar arteriovenous malformation: illustrative case.

Background: Bilateral inferior colliculus (IC) infarction is a rare condition that can lead to severe auditory deficits. Cerebellar arteriovenous malformations (AVMs) treated with endovascular embolization pose a risk for ischemic complications affecting the brainstem.

Observations: A 54-year-old male presented with intermittent headaches and imbalance, and, following a fall, a subarachnoid hemorrhage and cerebellar AVM were identified.

Effects of whole-body vibration in horizontal position on bone, quality of life, and balance in postmenopausal osteoporosis.

Objectives: The present study aimed to analyze the effect of high-frequency, low-magnitude whole-body vibration (WBV) therapy in horizontal position on bone, quality of life, pain, and balance in postmenopausal women.

Patients And Methods: Sixty postmenopausal women were included in this prospective, randomized controlled study between May 2015 to September 2015. The patients were randomized into three groups, with 20 participants in each group: WBV + infrared group, infrared group, and control group.

Partially Hydrolyzed Poly(2-alkyl/aryl-2-oxazoline)s as Thermal Latent Curing Agents: Effect of Composition and Pendant Groups on Curing Behavior.

Poly(2-alkyl/aryl-2-oxazoline)-polyethylenimine (POZ-PEI) copolymers resulting from the partial hydrolysis of poly(2-alkyl/aryl-2-oxazoline)s (POZs) offer highly tunable properties. The amine groups on the PEI units are suitable for a range of postpolymerization modifications such as ring-opening of epoxides, acylation, and coupling. The reactivity of these amines can be controlled by altering the available structural variables of the copolymer.

Exploring efavirenz-DNA interactions: A multidisciplinary approach through electrochemical, toxicological, and in silico investigations.

Recently, there has been a growing approach that approved drugs have been tested for additional purposes. Efavirenz is a non-nucleoside reverse transcriptase inhibitor used to treat human immunodeficiency virus infection. In addition, it has selective cytotoxic effects against cancer cells.

Search for Magnetic Monopole Pair Production in Ultraperipheral Pb+Pb Collisions at sqrt[s_{NN}]=5.36 TeV with the ATLAS Detector at the LHC.

This Letter presents a search for highly ionizing magnetic monopoles in 262  μb^{-1} of ultraperipheral Pb+Pb collision data at sqrt[s_{NN}]=5.36  TeV collected by the ATLAS detector at the LHC. A new methodology that exploits the properties of clusters of hits reconstructed in the innermost silicon detector layers is introduced to study highly ionizing particles in heavy-ion data.

Clinical management of three JMML siblings with germline CBL variation.

Germline pathogenic variants (PVs) in CBL are found in 15 % of juvenile myelomonocytic leukemia (JMML) cases. Here we report three siblings with CBL(NM_005188):c.1111T>C variation presenting a heterogenous JMML clinic and outcome.

Investigation of the Effectiveness of a Biopsychosocial-Based Exercise Approach in Rheumatic Diseases: A Mixed Methods Research With Patients' Perspectives.

Aims And Objectives: To investigate the effectiveness and acceptability, and thus practicability of a biopsychosocial-based exercise model in rheumatic diseases by a mixed method.

Method: This study is within the framework of mixed-method research that combines the strengths of quantitative and qualitative research methodologies. For the quantitative part of the study, 81 patients were divided into two groups Bilişsel Egzersiz Terapi Yaklaşımı (BETY)- (Cognitive Exercise Therapy Approach in English) exercise group (BETY Group-BG) and control group (CG).

From diagnosis to desensitization in immediate hypersensitivity reactions to both oral and parenteral iron salts.

Hypersensitivity reactions (HRs) to iron agents are increasing in parallel with increased use of iron preparations. We aimed to evaluate the clinical features and our previous desensitization protocol in patients with immediate hypersensitivity reactions (IHR) to iron agents. We screened the medical records of 96 patients with a history of IHRs to oral or intravenous (IV) iron agents.

Validation of the Finnish Diabetes Risk Score and development of a country-specific diabetes prediction model for Turkey.

Aims: Diabetes is a global health concern, and early identification of high-risk individuals is crucial for preventive interventions. Finnish Diabetes Risk Score (FINDRISC) is a widely accepted non-invasive tool that estimates the 10-year diabetes risk. This study aims to validate the FINDRISC in the Turkish population and develop a specific model using data from a nationwide cohort.

Microstructure and Release Behavior of Alginate-Natural Hydrocolloid Composites: A Comparative Study.

This study investigated the effects of combining sodium alginate (ALG) with various natural hydrocolloids on the microstructure and release behaviors of microbeads. The encapsulation solutions were prepared at a 1:1 (/) ratio with ALG as the control and carrageenan (CAR), locust bean gum (LBG), acacia gum (ACA), pectin (PEC), and carboxymethyl cellulose (CMC) as experimental groups. Each formulation contained 0.

Novel c.1303C>T Variant Led to Diagnosis of Intellectual Developmental Disorder with Autism and Speech Delay: Application of Comprehensive Family-Based Whole-Genome Analysis.

Background: Intellectual developmental disorder with autism and speech delay (IDDAS) is a rare and complex neurological disorder characterized by the presence of both intellectual and speech impairment and features of autism spectrum disorder (ASD). The prevalence of IDDAS is unknown but genetically, it is caused by heterozygous variants in the gene.

Methods: A 7-year-old female with autistic features and delayed speech development was presented with unaffected parents.

3D Geometric Morphometric Analysis of Calcaneal Morphology in Domestic Caprinae: Sheep () and Goat ().

The calcaneus plays a critical role in balance, locomotion, and muscle attachment, making it a key structure for biomechanical adaptations. This study examined interspecies differences between sheep and goats, as well as intraspecies variations among different sheep breeds, in calcaneus morphology. A total of 128 right calcanei were analyzed using 3D geometric morphometric methods to allow detailed assessments of calcaneus shape and size.

Antifungal Testing of Vaginal Isolates in Pregnant Women: A Retrospective, Single-Center Study in Adana, Türkiye.

Clinical and mycological data are essential for the optimal management of patients with vaginitis (CV), particularly in cases of (i) azole-resistant . vaginitis, (ii) recurrent CV, and (iii) CV in pregnant women. The present retrospective single-center study investigated the antifungal activity of six commonly used antifungals against randomly selected vaginal isolates recovered from 68 pregnant women in Adana, Türkiye, including .

Correlation of PD-L1 and HIF-1 Alpha Expression with KRAS Mutation and Clinicopathological Parameters in Non-Small Cell Lung Cancer.

Lung cancer remains the leading cause of cancer-related deaths worldwide, with non-small cell lung carcinomas (NSCLCs) comprising the majority of cases. Among the common driver mutations, KRAS plays a critical role in guiding treatment strategies. This study evaluates the expression of programmed death-ligand 1 (PD-L1) and hypoxia-inducible factor 1-alpha (HIF-1α) in -mutant NSCLCs and investigates their associations with clinicopathological findings.

Gesture Reduces Mapping Difficulties in the Development of Spatial Language Depending on the Complexity of Spatial Relations.

In spoken languages, children acquire locative terms in a cross-linguistically stable order. Terms similar in meaning to in and on emerge earlier than those similar to front and behind, followed by left and right. This order has been attributed to the complexity of the relations expressed by different locative terms.

A rare and challenging pediatric case of drug toxicity and immune reconstitution inflammatory syndrome during the treatment of intracranial tuberculoma: A case report.

Intracranial tuberculoma represents one of the most severe complications of central nervous system tuberculosis (TB), with an incidence that is relatively low. In cases of intracranial tuberculoma, patients may develop drug toxicity and/or immune reconstitution inflammatory syndrome (IRIS) while receiving anti-TB treatment. The current study presented the case of a seven-year-old female patient with intracranial tuberculoma who developed drug-induced hepatotoxicity and IRIS during the course of treatment.

Skull morphology in native and non-native cattle breeds in Türkiye.

This study aims to investigate morphological differences in the skulls of cattle breeds with different functional roles and geographical origins and to examine skull shape variations among breeds using geometric morphometrics methods. To this end, 95 skulls from Native (Eastern Anatolian Red and Southern Anatolian Red) and Non-native (Holstein and Simmental) breeds raised in Türkiye were analyzed. The results show a significant size difference between Native Breeds and Non-native Breeds, with the Non-native Breeds having larger skulls.

Early sepsis recognition: a pilot study using a rapid high-multiplex host-response mRNA diagnostic test.

Background: Early sepsis diagnosis is essential to allow timely initiation of adequate care. The TriVerity™ Test, performed on the Myrna™ Instrument, is the first rapid high-multiplex host-response mRNA diagnostic test that supports clinical decision-making by evaluating the likelihood of bacterial and/or viral infections and severity of illness. We present findings of the first, proof of concept, real-world evaluation in an emergency department (ED).