Disentangling Sources of Momentum Fluctuations in Xe+Xe and Pb+Pb Collisions with the ATLAS Detector.

High-energy nuclear collisions create a quark-gluon plasma, whose initial condition and subsequent expansion vary from event to event, impacting the distribution of the eventwise average transverse momentum [P([p_{T}])]. Disentangling the contributions from fluctuations in the nuclear overlap size (geometrical component) and other sources at a fixed size (intrinsic component) remains a challenge. This problem is addressed by measuring the mean, variance, and skewness of P([p_{T}]) in ^{208}Pb+^{208}Pb and ^{129}Xe+^{129}Xe collisions at sqrt[s_{NN}]=5.

dEREGulated pathways: Unraveling the role of epiregulin in skin, kidney and lung fibrosis.

The epidermal growth factor receptor (EGFR) signaling pathway is an evolutionary conserved mechanism to control cell behavior during tissue development and homeostasis. Deregulation of this pathway has been associated with abnormal cell behavior, including hyperproliferation, senescence, and an inflammatory cell phenotype, thereby contributing to pathologies across a variety of organs, including kidney, skin, and lung. To date, there are seven distinct EGFR ligands described.

Spin Waves and Three Dimensionality in the High-Pressure Antiferromagnetic Phase of SrCu_{2}(BO_{3})_{2}.

Quantum magnetic materials can provide explicit realizations of paradigm models in quantum many-body physics. In this context, SrCu_{2}(BO_{3})_{2} is a faithful realization of the Shastry-Sutherland model for ideally frustrated spin dimers, even displaying several of its quantum magnetic phases as a function of pressure. We perform inelastic neutron scattering measurements on SrCu_{2}(BO_{3})_{2} at 5.

Surgical management of cervical malignant spinal lesions: a retrospective study of cervical spine metastases and multiple myeloma cases.

Purpose: This study introduces a retrospective analysis of the surgical management of 213 consecutive cases of cervical spine metastases and Multiple Myeloma Cases.

Materials And Methods: Retrospective analysis of prospectively collected data in a single surgical center of patients who underwent surgery for tumors of the cervical spine between 1994 and 2017. Exclusion criteria were intradural tumors and primary tumors.

Estimating effective reproduction numbers using wastewater data from multiple sewersheds for SARS-CoV-2 in California counties.

The effective reproduction number serves as a metric of population-wide, time-varying disease spread. During the early years of the COVID-19 pandemic, this metric was primarily derived from case data, which has varied in quality and representativeness due to changes in testing volume, test-seeking behavior, and resource constraints. Deriving nowcasting estimates from alternative data sources such as wastewater provides complementary information that could inform future public health responses.

The impact of restricted chests on long-term lung function parameters following lung transplantation in patients with interstitial lung disease.

Objectives: In patients with interstitial lung disease (ILD), the diaphragm typically rises as the lungs chronically shrink. However, the grade of restriction differs in each patient. It is currently unknown, how disparities between actual and predicted recipient total lung capacity (TLC), impact changes in lung function parameters and long-term outcomes following lung transplantation (LTx).

Microbial Community of a Sandy Beach Subterranean Estuary is Spatially Heterogeneous and Impacted by Winter Waves.

Subterranean estuaries (STEs) are critical ecosystems at the interface of meteoric groundwater and subsurface seawater that are threatened by sea level rise. To characterize the influence of tides and waves on the STE microbial community, we collected porewater samples from a high-energy beach STE at Stinson Beach, California, USA, over the two-week neap-spring tidal transition during both a wet and dry season. The microbial community, analyzed by 16S rRNA gene (V4) amplicon sequencing, clustered according to consistent physicochemical features found within STEs.

Exploring the influence of urban art interventions on attraction and wellbeing: an empirical field experiment.

While cities are attractive places, brimming with opportunities and possibilities for their inhabitants, they have also been found to have negative consequences, especially on physical and mental health. In a world of ever-growing urban populations, it is important to understand how to make cities healthier and more pleasant places to live. In the present study, we investigated the impact of art as an urban intervention and compared it to the well-known effects of greenery (i.

Evaluation of wheat blast resistance in the USDA hard winter wheat ( L.) Northern and Southern Regional Performance Nurseries.

Wheat blast, caused by the pathotype of , is an emerging disease that threatens the global supply of wheat. The pathogen was first reported in Brazil and subsequently spread to the neighboring countries of Argentina, Bolivia, and Paraguay. More recently, wheat blast was reported in Asia and Africa, having been observed in Bangladesh and Zambia.

Peptide receptor radionuclide therapy for ectopic Cushing's syndrome caused by metastatic neuroendocrine neoplasms.

Background: Metastatic gastroenteropancreatic neuroendocrine neoplasms (GEPNEN) can cause ectopic Cushing's syndrome (ECS). ECS is highly morbid and medical therapy is complex and can be ineffective. Patients unsuitable for bilateral adrenalectomy (BA) have dismal outcomes.

Broadband giant nonlinear response using electrically tunable polaritonic metasurfaces.

Intersubband transitions in semiconductor heterostructures offer a way to achieve large and designable nonlinearities with dynamic modulation of intersubband energies through the Stark effect. One promising approach for incorporating these nonlinearities into free space optics is a nonlinear polaritonic metasurface, which derives resonant coupling between intersubband nonlinearities and optical modes in nanocavities. Recent work has shown efficient frequency mixing at low pumping intensities, with the ability to electrically tune the phase, amplitude, and spectral peak of it.

The paracetamol metabolite N-acetyl-4-benzoquinoneimine (NAPQI) prevents modulation of K7 channels via G-protein coupled receptors by interference with PIP and Ca sensitivity.

Background And Purpose: Paracetamol has been found to alleviate inflammatory pain by modulating K7 channels. Its metabolite N-acetyl-4-benzoquinoneimine (NAPQI) increases currents through these channels via a stretch of three cysteine residues in the channel S2-S3 linker. Through this effect, the excitability of neurons in the pain pathway is dampened.

Transcranial ultrasound modeling using the spectral-element method.

This work explores techniques for accurately modeling the propagation of ultrasound waves in lossy fluid-solid media, such as within transcranial ultrasound, using the spectral-element method. The objectives of this work are twofold, namely, (1) to present a formulation of the coupled viscoacoustic-viscoelastic wave equation for the spectral-element method in order to incorporate attenuation in both fluid and solid regions and (2) to provide an end-to-end workflow for performing spectral-element simulations in transcranial ultrasound. The matrix-free implementation of this high-order finite-element method is very well-suited for performing waveform-based ultrasound simulations for both transcranial imaging and focused ultrasound treatment thanks to its excellent accuracy, flexibility for dealing with complex geometries, and computational efficiency.

Probing TCR Specificity Using Artificial In Vivo Diversification of CDR3 Regions.

The T-cell receptor sequences expressed on cells recognizing a specific peptide in the context of a given MHC molecule can be explored for common features that might explain their antigen specificity. However, despite the development of numerous experimental and bioinformatic strategies, the specificity problem remains unresolved. To address the need for additional experimental paradigms, we report here on an in vivo experimental strategy designed to artificially diversify a transgenic TCR by CRISPR/Cas9-mediated mutagenesis of Tcra and Tcrb chain genes.

Breastfeeding and contrast agents-A critical review and presentation of new aspects.

Background: There are discrepancies between guidelines of scientific societies and information of the package inserts of contrast media concerning breastfeeding following the application of a contrast agent to the mother.

Objectives: The contents of different review articles reflect the opinion of scientific societies. Consequently, in clinical routine settings it is difficult to find the optimal advice for a breastfeeding woman and her baby.

Kinetic and Mechanistic Release Studies on Hyaluronan Hydrogels for Their Potential Use as a pH-Responsive Drug Delivery Device.

Hyaluronic acid, a biocompatible polymer, holds significant potential for drug delivery applications. Its variable degree of protonation, which entails tunable physical properties, makes it an ideal candidate for developing pH-sensitive hydrogels. Like other smart drug delivery systems, pH-responsive hydrogels can enhance medical treatment and expedite the healing process.

Patient-psychologist telemedicine interactions in an intensive care unit recovery clinic: Qualitative secondary analysis.

Objectives: We aimed to describe the content of patient-psychologist mental health related dialogues during a telemedicine intensive care unit recovery clinic visit.

Research Methodology/design: Qualitative descriptive study nested within a randomized controlled pilot trial to assess a telemedicine intensive care unit recovery clinic feasibility and preliminary efficacy. Participants included adults hospitalized with sepsis and/or respiratory failure.

Coupling of unactivated alkyl electrophiles using frustrated ion pairs.

Cross-electrophile coupling reactions have evolved into a major strategy for rapidly assembling important organic molecules. Two readily accessible electrophiles are coupled to form new C-C bonds, providing a key advantage over traditional cross-coupling strategies that require the preformation of reactive organometallic species. Yet, the formation of C(sp)-C(sp) bonds that form the core of nearly all organic compounds remains highly challenging with current approaches, calling for the design of innovative new strategies.

Health Economic Evaluation of Antimicrobial Stewardship, Procalcitonin Testing, and Rapid Blood Culture Identification in Sepsis Care: A 90-Day Model-Based, Cost-Utility Analysis.

Objective: We evaluated the cost-effectiveness of a bundled intervention including an antimicrobial stewardship program (ASP), procalcitonin (PCT) testing, and rapid blood culture identification (BCID), compared with pre-implementation standard care in critically ill adult patients with sepsis.

Methods: We conducted a decision tree model-based cost-effectiveness analysis alongside a previously published pre- and post-implementation quality improvement study. We adopted a public Canadian healthcare payer's perspective.

SARS-CoV-2 surveillance in US wastewater: Leading indicators and data variability analysis in 2023-2024.

Wastewater-Based Epidemiology (WBE) has become a powerful tool for assessing disease occurrence in communities. This study investigates the coronavirus disease 2019 (COVID-19) epidemic in the United States during 2023-2024 using wastewater data from 189 wastewater treatment plants in 40 states and the District of Columbia. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and pepper-mild mottle virus normalized SARS-CoV-2 RNA concentration data were compared with COVID-19 hospitalization admission data at both national and state levels.