Pediatric Formulation Optimization Using a Rational Design: Exploring Amorphous Solid Dispersion Technology with Terbinafine Hydrochloride as a Case Study.

Developing orally administered pediatric formulations presents significant challenges due to the unique characteristics of pediatric patients. Terbinafine hydrochloride (TER), a powerful antifungal agent, is effective against various fungal infections, including Tinea capitis, which is common in children. However, its low aqueous solubility necessitates innovative pharmaceutical strategies to enhance its effectiveness.

Interactive breastfeeding theory: fawcett's pragmatic adequacy assessment.

Objective: To assess the pragmatic adequacy of the Interactive Theory of Breastfeeding based on the Fawcett's Model.

Method: Theoretical study, according to evaluation criteria proposed by Fawcett. The six questions suggested in the model were used, answered based on searches in scientific literature, consultation in legislation supporting nursing professional practice and information from the authors of the theory.

Consumption of food markers of a healthy diet according to racial groups of women in Brazil.

This article aims to analyze the consumption of healthy food consumption markers, according to racial groups of Brazilian women interviewed in the 2019 National Health Survey (NHS). This work was a cross-sectional study with data from 45,148 white and black women, aged ≥ 20 years. The variables used were the consumption of fruits, vegetables and legumes, beans, and fish.

Ineffective coping (00069): A Walker and Avant conceptual analysis.

Purpose: To analyze the diagnostic concept of "ineffective coping" (00069) proposed by NANDA-I, using Walker and Avant's framework.

Data Sources: The theoretical framework of Walker and Avant was used for the concept analysis. A search was performed in the Virtual Health Library portal using the keywords "ineffective coping" and "enfrentamento ineficaz.

Delusional infestation treated with risperidone: a series of 27 patients.

Background: Patients with delusional infestation (DI) frequently refuse to be treated with psychoactive drugs. In the past, pimozide was commonly used as a first-line agent but is now prescribed more rarely. Risperidone was first used to treat DI in 1995.

Inclusion complex of ketoconazole and p-sulfonic acid calix[6]arene improves antileishmanial activity and selectivity against Leishmania amazonensis and Leishmania infantum.

Many previous studies presented the effectiveness of ketoconazole (KTZ) against leishmaniasis. However, the bioavailability and therapeutic efficacy of free KTZ are limited due to its low aqueous solubility. In this study, an inclusion complex (IC6HKTZ) was prepared with p-sulfonic acid calix[6]arene (CX6SOH) to improve the solubility and efficacy of KTZ against Leishmania amazonensis and Leishmania infantum promastigotes.

Simultaneous concept analysis of nursing diagnoses related to respiratory function.

Aim: To perform a simultaneous concept analysis of the concepts associated to nursing diagnoses ineffective airway clearance, ineffective breathing pattern, and impaired gas exchange.

Background: Concepts about respiratory manifestations need to be well defined, especially in the current pandemic scenario. For that, the simultaneous concept analysis can help in the clarity and differentiation of similar concepts.

Growth model analysis of wild hyacinth macaw (Anodorhynchus hyacinthinus) nestlings based on long-term monitoring in the Brazilian Pantanal.

Studies on the breeding of vulnerable and endangered bird species are hindered by low numbers of individuals, inaccessible location of nests, unfavourable environmental conditions, and complex behavioural patterns. In addition, intraspecific variation may emerge only following long-term, systematic observations of little-known patterns and processes. Here, data collected over 30 years were used to determine growth model of hyacinth macaw (Anodorhynchus hyacinthinus) chicks in the Pantanal biome of Brazil.

Effects on pain and cognition of transcranial direct current stimulation over the dorsolateral prefrontal cortex in women with chronic migraine.

We compared the effects of one versus two daily sessions of anodal transcranial direct current stimulation (a-tDCS) delivered to the left dorsolateral prefrontal cortex (DLPFC) for 10 days in a cohort of 30 women (mean age 28.0±6.92) with chronic migraine (CM, disease duration: 37.

Bioactivity of Meliaceae, Amaryllidaceae, Solanaceae and Amaranthaceae plant aqueous extracts against the cattle tick .

Commercial synthetic acaricides have selected resistant populations of , and generate residues in the environment or in milk/cattle products. In this study, aqueous extracts (AE) from (Maz), , , (Nta) and were evaluated for the bioactivity against the cattle tick. The treatment using Nta or Maz AE resulted in the lowest egg hatching rate (34.

Effects of the nursing intervention Fall prevention in older adults with arterial hypertension using NANDA-I, NIC, and NOC.

Purpose: To measure the effects of the NIC intervention fall prevention on the magnitude of the NANDA-I Risk for falls' risk factors and of NOC indicators related to falls in older adults with arterial hypertension.

Background: Nurses can use nursing taxonomies to provide effective care in preventing falls in specific populations.

Methods: Clinical, randomized, open, parallel, and multicenter trial following the CONSORT recommendations for nonpharmacological trials.

Cytogenetic and molecular abnormalities in Waldenström's macroglobulinemia patients: Correlations and prognostic impact.

While Waldenström macroglobulinemia (WM) is characterized by an almost unifying mutation in MYD88, clinical presentation at diagnosis and response to therapy can be widely different among WM patients. Current prognostic tools only partially address this clinical heterogeneity. Limited data compiling both molecular and cytogenetic information have been used in risk prognostication in WM.

Nursing diagnosis neonatal hyperbilirubinemia: A survival analysis.

Purpose: To analyze the short-term survival of the nursing diagnosis of neonatal hyperbilirubinemia in hospitalized neonates within the first 24 h of life and over a maximum of 7 days.

Methods: A prospective open cohort study with a longitudinal design was developed with 120 newborns during the first 24 h of life. The survival rate after a nursing diagnosis of neonatal hyperbilirubinemia was analyzed for 7 days.

Content validity of the nursing diagnostic Breathing Pattern, Ineffective, in children with congenital heart defects.

Objective: To estimate the content validity of the nursing diagnostic Breathing Pattern, Ineffective, in children with congenital heart defects.

Method: Methodological study in two stages: 1) integrative literature review; 2) content validation, with 23 nurses. An instrument with 10 related factors and 21 defining characteristics for data collection was used.

Organophosphate poisoning of Hyacinth Macaws in the Southern Pantanal, Brazil.

The populations of hyacinth macaws (Anodorhynchus hyacinthinus), an emblematic species, have suffered declines due to many environmental factors. The Hyacinth Macaw Institute's actions are showing positive outcomes for the conservation of A. hyacinthinus.

Diagnostic indicators of risk-prone health behaviors in pregnant adolescents.

Purpose: This study aimed to identify diagnostic indicators associated with the nursing diagnosis risk-prone health behaviors in pregnant adolescents.

Methods: We conducted a cross-sectional study. The sample consisted of 181 pregnant adolescents.

The factors related to a sedentary lifestyle: A meta-analysis review.

Aims: To compare factors associated with the sedentary lifestyle described in the literature with the factors listed in NANDA International.

Design: Systematic review with meta-analysis of factors associated with a sedentary lifestyle in adolescents, adults and older people.

Data Sources: An electronic search of PubMed, Scopus, CINAHL and Latin America and the Caribbean Literature on Health and Science databases conducted in May 2016.

Anxiety and depression: a study of psychoaffective, family-related, and daily-life factors in celiac individuals.

Objective: To identify the prevalence of anxiety and depression and its association with psychoaffective, family-related, and daily-life variables of celiac individuals.

Methods: Crosssectional study, developed with 83 celiac patients in Fortaleza. An instrument was applied with variables grouped in the categories: psychoaffective, family-related, and daily-life.

Accuracy of the clinical indicators of ineffective health management in celiac people.

Objective: to analyze the accuracy of clinical indicators of "Ineffective health management" in celiac patients and to verify associations between sociodemographic characteristics and clinical indicators.

Method: a cross-sectional study, conducted from May to September 2017, with 83 celiac patients, through an interview. Accuracy measures were defined by latent class model.

Clinical Indicators of Impaired Swallowing in Children with Neurological Disorders.

Objective: To investigate the clinical indicators of the nursing diagnosis impaired swallowing in children with neurological disorders.

Methods: An integrative review was performed on the Scopus, Web of Science, PubMed, Lilacs and Cinahl databases; by crossing the terms impaired degluition, dyphagia, deglutition disorders, cerebral palsy, microcephaly, which resulted in 45 articles.

Results: Eighteen indicators were identified in the oral phase, ten in the pharyngeal phase, and nine in the esophageal phase.