[RBCs inclusions after splenectomy: not only Howell-Jolly bodies!].

We report on several abnormalities of the red blood cells, in particular erythrocytic inclusions, in a 49 year old man. The blood smear presented with marked anisocytosis, target cells, acanthocytes and Howell-Jolly bodies, as well as Pappenheimer bodies and basophilic stippling. These abnormalities can be explained by the clinical context which associated splenectomy, iron overload and severe denutrition.

Analysis of differential PDT effect in rat bladder tumor models according to concentrations of intravesical hexyl-aminolevulinate.

The hexylester of 5-aminolevulinic acid (HAL) is a very efficient precursor of the photosensitizer protoporphyrin IX (PpIX) for photodynamic therapy (PDT). Our previous study, performed in rat orthotopic bladder tumors, indicated an opposite effect of HAL/PpIX-PDT according to HAL concentration. The present study investigated possible reasons for this differential effect considering the impact of extracted amounts of PpIX in normal and tumor bearing bladders along with PpIX distribution in distinctive histopathological layers.

[Disseminated infestation of Enterocytozooon bieneusi a an HIV-infected patient].

An HIV-positive patient developed disseminated Enterocytozoon bieneusi infection. The parasite was identified in stool, duodenal biopsy, nasal discharge, and sputum specimens using transmission electron microscopy. Albendazole therapy failed to improve the symptoms or eradicate the parasite.

Enterocytozoon bieneusi multiorgan microsporidiosis in a HIV-infected patient.

Multiorgan microsporidiosis due to Enterocytozoon bieneusi was diagnosed in an HIV-infected patient. The parasite was found and identified as E. bieneusi by transmission electron microscopy in stools, duodenal biopsy, nasal discharge and sputum.

Ultrastructural changes in the duodenal mucosa induced by ingested histamine in patients with chronic urticaria.

Histamine in food may be responsible for some cases of food intolerance. We previously demonstrated disturbances in the metabolism of ingested histamine in patients with chronic urticaria (CU) and proposed that this could be related to increased intestinal permeability to histamine. The present study was undertaken to look for ultrastructural changes in the intestinal tract that might explain this abnormality.

[Scanning electron microscopic study of Campylobacter pylori and associated gastroduodenal lesions].

The detection of Campylobacter pylori was carried out with scanning electron microscopy (SEM) on 4,590 biopsies taken from 1,714 adult patients (1,348 duodenal biopsies, 1,690 antral biopsies and 1,552 fundic biopsies). The mucus was removed and the fragments of mucosa were then fixed with glutaraldehyde, dehydrated, critical point-dried with CO2 or hexamethyldisilazane, mounted, coated with gold, and observed with SEM. Under SEM, C.

[Evaluation of the histopathologic effects following subconjunctival injection of corticoids in immediate- and retard-action forms].

We comparatively studied histopathologic impairments following subconjonctival injections of long and short acting corticosteroids and saline. 44 conjunctival biopsies were performed in the site of injection. The tissues were evaluated by light and electron microscopy.

Cellular uptake, cytotoxic and mutagenic effects of insoluble chromic oxide in V79 Chinese hamster cells.

The cellular uptake, the cytotoxicity and the induction of resistance to 6-thioguanine (6-TG) in Chinese hamster V79 cells exposed to insoluble crystalline trivalent chromium [Cr(III)], Cr2O3, were investigated. Intracytoplasmic Cr2O3 crystalline particle-containing vacuoles were observed by electron microscopy. Concentrations of 50-200 micrograms/ml did not have a marked killing effect but did show a predominantly concentration-dependent inhibitory effect on cell cycle progression with accumulation of cells in G2 phase.

[Hyalinosis cutis and mucosae. Ultrastructural histochemical aspects indicating intracellular accumulation of glycosaminoglycans].

The exact nature of the genetic defect of hyalinosis cutis et mucosae or d'Urbach-Whiete syndrome is still matter of controversy. The present article reports on three new cases in which several different ultrastructural and biochemical investigations add more arguments to support an anomaly of the glycosaminoglycans degradation in the dermal fibroblasts. Cationic dyes as polyethyleneimine and alcian blue show an intense ultrastructural staining of the abnormal basal laminae and the intracellular lysosomal bodies in cultured fibroblasts.

Familial hyperthyroidism without evidence of autoimmunity.

Thirty-four members of a single family were studied and 9 of them were found to be suffering from hyperthyroidism associated with diffuse goitre. Exophthalmos was absent and transmission seemed to be independent of HLA type. Four of the 9 were studied prior to treatment but in all cases serum immunoglobulin levels were normal, antithyroglobulin and antimicrosomal antibodies absent, thyroid stimulating antibodies negative and the lymphocyte transformation responses to mitogens not different from those of controls.

[Familial presenile dementia: Gerstmann-Sträussler-Scheinker's syndrome (author's transl)].

A similar affection has developed in eight members from four generations of a family living in the Alsace. The disease is characterized by the onset of a pyramidal, pseudobulbar syndrome and dementia during the third or fourth decade of life. The outcome is fatal after a mean period of three years.

[Effect of diphenylhydantoin administered during gestation and lactation on the motor development and cerebellar histology of the young rat].

Rattus norvegicus females were treated by diphenylhydantoin (D.P.H.

[Ultrastructural cytochemistry of human spermatozoa].

Enzymatic activities and repartition of glycoproteins were studied with electron microscopy in human ejaculated spermatozoa. Enzymatic activities are localised in the head of spermatozoon: arylsulfatase in the acrosome, acid phosphatase in the periacrosomal cytoplasm. Phosphotungstic acid at low pH and colloïdal iron allow detection of glycoproteins and acid groups on the sperm cell surface.

[Ultrastructural study of the follicular cells of the adenohypophysis of the chicken].

As in other species, a network of follicular cells linked together by functional complexes can be observed by electron microscopy in the adenohypophysis of the chick. No secretory granules are seen in the follicular cells. They are connected with each other by thin and long processes inserted between the glandular cells and the perivascular spaces.

[Immunocytochemistry of pituitary corticotroph cells in terrestrial turtle (Testudo mauritanica)].

The immunocytochemical and histochemical characters of the corticotroph cells of the Turtle adenohypophysis have been studied. These cells are localised in the rostral part of the gland and are revealed by Is anti ACTH (1-24) and (17-39). They are also colored with lead hematoxyline and PAS-Orange G.