Publications by authors named "Gudrun Neumann"

Background: Sentinel lymph node mapping is a minimally invasive surgical staging procedure that allows identification of macro- and micrometastases. The implementation of sentinel lymph node mapping to women with low-grade endometrial cancer allows detection of lymph node metastases and avoids the morbidity of radical pelvic lymphadenectomy. The extent of myometrial invasion is highly predictive of lymph node metastases but is hard to determine precisely preoperatively.

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Introduction: The objective of the study was to provide a comprehensive description of perioperative morbidity associated with robot-assisted surgery (RAS) in a gynecological oncology setting in order to improve the preoperative counseling of women and support shared decision-making.

Material And Methods: All women scheduled for intended RAS between January 2015 and December 2022 were prospectively included in an electronic morbidity database for the analyses of perioperative complications.

Results: In total, 2225 women were included.

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Introduction: It is unclear if sentinel node (SLN) mapping can replace pelvic- (PLD) and paraaortic lymphadenectomy (PALD) for high-risk endometrial cancer (EC). A diagnostically safe surgical algorithm, taking failed mapping cases into account, is not defined. We aimed to investigate the diagnostic accuracy of SLN mapping algorithms in women with exclusively high-risk EC.

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Article Synopsis
  • The SENTIREC-endo study explores the safety and effectiveness of sentinel lymph node (SLN) mapping in women with early-stage low-grade endometrial cancer, specifically focusing on those with low- and intermediate-risk for lymph node metastases.
  • A multicenter study from March 2017 to February 2022 included 627 women, showing a high SLN detection rate of 94.3% and revealing a low overall incidence of lymph node metastases at 9.3%.
  • The results indicate minimal postoperative complications (only 8%) and a very low incidence of lymphedema, suggesting that SLN mapping is a safe technique that can improve treatment for low- and intermediate-risk endometrial cancer patients.
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This is a case report of a 56-year-old woman with a history of postmenopausal bleeding, who presented with an endometrioid adenocarcinoma and a co-existing non-gestational choriocarcinoma. We performed robotic assisted hysterectomy, bilateral oophorectomy and pelvic lymphadectomy, and histopathologic examination revealed a malignant tumour showing an endometrioid adenocarcinoma grade 2 with a minor component of choriocarcinoma incorporated into the adenocarcinoma. We compared data from exome sequencing of DNA from tumour and blood to show, that the choriocarcinoma component was most likely non-gestational.

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Purpose: Malignant cells exhibit increased rates of aerobic glycolysis. Here, we tested whether the accumulation of fluoro-deoxyglucose-6-phosphate (FDG6P) in ovarian cancers of differential malignancy reflects inversely correlated elevations of hexokinase (HK) and glucose-6-phosphatase (G6Pase) activities.

Procedures: Twenty-nine women with suspected ovarian cancer had positron emission tomography (PET) prior to surgery.

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Objective: To describe the outcome of adult granulosa cell tumor (AGCT) with respect to initial clinical findings, methods of surgery, and perioperative treatment.

Study Design: Retrospective follow-up study.

Setting: All hospitals in Jutland.

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We present a case study of a 43 year-old female immigrant from Turkey with abdominal pain, ascites and elevated cancer antigen 125. The symptoms were similar to those of ovarian cancer, and imaging (computed tomography (CT), positron emission tomography/computed tomography and magnetic resonance imaging) supported this suspicion. Peritoneal biopsy from laparoscopy showed granulomas with central necrosis.

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Background: We report a rare case of a cervical adenosquamous carcinoma, initially diagnosed during delivery, with subsequent implantation in the episiotomy scar 5 weeks postpartum.

Case: A 35-year-old woman with cervical adenosquamous carcinoma diagnosed during delivery was treated with radical abdominal hysterectomy with bilateral pelvic lymphadenectomy. Five weeks later the metastatic tumor at the episiotomy site was excised, and the patient received adjuvant chemotherapy and radiation therapy.

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Objectives: To compare the prevalence of urological symptoms in a population of women, who had a transcervical endometrial resection (TCER) only, and a population of women, who had a TCER and a subsequent hysterectomy. The superior goal was to evaluate the possible association between hysterectomy and urinary incontinence.

Design: All women, who had a TCER at our department during the period of 1990-1996 received a questionnaire with focus on urological symptoms.

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The aim of the study is to investigate the changes in continence status in a population of women hysterectomized in 1998-2000. Four hundred fifteen hysterectomized women who participated in a questionnaire study on continence status in September 2001 were retested with the same questionnaire on actual continence status in January 2005. As controls we used 97 women who had a laparoscopic cholecystectomy in 1999-2000 and were tested and retested similarly.

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The aim of this study was to determine the short-term prevalence of de novo urinary symptoms after hysterectomy indicated by meno/metrorrhagia or dysmenorrhea/dyspareunia. The study group consisted of 451 women who had had a hysterectomy for reasons of meno/metrorrhagia or dysmenorrhea/dyspareunia. Fifty-three (12%) had a supracervical, 151 (33%) a total abdominal and 247 (55%) a vaginal hysterectomy.

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Aim Of Study: To investigate the association between obesity and peri- or postoperative complications after hysterectomy for nonmalignant bleeding disorders.

Material And Methods: Data from 444 vaginal hysterectomies and 503 abdominal hysterectomies indicated by benign bleeding disorders were drawn from a regional database. Data on peri- or postoperative complications and postoperative stay were related to preoperative body mass index (BMI).

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Sarcoidosis rarely affects the female genitalia. We report a 36-year-old woman who had a hysterectomy for metrorrhagia. Histologic examination showed sarcoid granulomas in the endometrium and myometrium.

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