Genetics of gene expression and its effect on disease.

Common human diseases result from the interplay of many genes and environmental factors. Therefore, a more integrative biology approach is needed to unravel the complexity and causes of such diseases. To elucidate the complexity of common human diseases such as obesity, we have analysed the expression of 23,720 transcripts in large population-based blood and adipose tissue cohorts comprehensively assessed for various phenotypes, including traits related to clinical obesity.

Reliability of quantitative EEG features.

Objective: To investigate the reliability of several well-known quantitative EEG (qEEG) features in the elderly in the resting, eyes closed condition and study the effects of epoch length and channel derivations on reliability.

Methods: Fifteen healthy adults, over 50 years of age, underwent 10 EEG recordings over a 2-month period. Various qEEG features derived from power spectral, coherence, entropy and complexity analysis of the EEG were computed.