Spatially resolved emulated annual temperature projections for overshoot pathways.

Due to insufficient climate action over the past decade, it is increasingly likely that 1.5 °C of global warming will be exceeded - at least temporarily - in the 21 century. Such a temporary temperature overshoot carries additional climate risks which are poorly understood.

Movement Termination of Slow-Wave Sleep-A Potential Biomarker?

The duration of slow-wave sleep (SWS) is related to the reported sleep quality and to the important variables of mental and physical health. The internal cues to end an episode of SWS are poorly understood. One such internal cue is the initiation of a body movement, which is detectable as electromyographic (EMG) activity in sleep-electroencephalography (EEG).

Anthropogenic climate change has influenced global river flow seasonality.

Riverine ecosystems have adapted to natural discharge variations across seasons. However, evidence suggesting that climate change has already impacted magnitudes of river flow seasonality is limited to local studies, mainly focusing on changes of mean or extreme flows. This study introduces the use of apportionment entropy as a robust measure to assess flow-volume nonuniformity across seasons, enabling a global analysis.

Evaluating Prophylactic Effect of Bovine Colostrum on Intestinal Barrier Function in Zonulin Transgenic Mice: A Transcriptomic Study.

The intestinal barrier comprises a single layer of epithelial cells tightly joined to form a physical barrier. Disruption or compromise of the intestinal barrier can lead to the inadvertent activation of immune cells, potentially causing an increased risk of chronic inflammation in various tissues. Recent research has suggested that specific dietary components may influence the function of the intestinal barrier, potentially offering a means to prevent or mitigate inflammatory disorders.

Increasingly negative tropical water-interannual CO growth rate coupling.

Terrestrial ecosystems have taken up about 32% of the total anthropogenic CO emissions in the past six decades. Large uncertainties in terrestrial carbon-climate feedbacks, however, make it difficult to predict how the land carbon sink will respond to future climate change. Interannual variations in the atmospheric CO growth rate (CGR) are dominated by land-atmosphere carbon fluxes in the tropics, providing an opportunity to explore land carbon-climate interactions.

Impact of COVID-19 pneumonia on pulmonary vascular volume.

Background: Pulmonary manifestations of COVID-19 pneumonia are well known. However, COVID-19 is also associated with a range of vascular manifestations such as embolism, congestion, and perfusion changes. Regarding congestion, research from different groups has suggested arteriovenous anastomosis dysregulation as a contributing factor.

Virtually Augmented Self-Hypnosis in Peripheral Vascular Intervention: A Randomized Controlled Trial.

Purpose: Hypnosis is useful for diminishing distress during medical procedures. This study investigated the efficacy of virtually augmented self-hypnosis as an adjunctive non-pharmacological method for procedural pain and anxiety relief during endovascular interventions (EVI).

Methods: We compared an immersive distraction experience (clinicaltrials.

Caravan - A global community dataset for large-sample hydrology.

High-quality datasets are essential to support hydrological science and modeling. Several CAMELS (Catchment Attributes and Meteorology for Large-sample Studies) datasets exist for specific countries or regions, however these datasets lack standardization, which makes global studies difficult. This paper introduces a dataset called Caravan (a series of CAMELS) that standardizes and aggregates seven existing large-sample hydrology datasets.

Prophylactic Effect of Bovine Colostrum on Intestinal Microbiota and Behavior in Wild-Type and Zonulin Transgenic Mice.

The microbiota-gut-brain axis (MGBA) involves bidirectional communication between intestinal microbiota and the gastrointestinal (GI) tract, central nervous system (CNS), neuroendocrine/neuroimmune systems, hypothalamic-pituitary-adrenal (HPA) axis, and enteric nervous system (ENS). The intestinal microbiota can influence host physiology and pathology. Dysbiosis involves the loss of beneficial microbial input or signal, diversity, and expansion of pathobionts, which can lead to loss of barrier function and increased intestinal permeability (IP).

[Migraine prevalence, migraine incidence and migraine drug prescriptions in primary care in the capital region of Iceland].

Introduction: The study aim was to describe migraine incidence over the ten-year periods, 2000-2009 and 2010-2019, in individuals aged 10-79 years in primary healthcare centre (PHCC) Sólvangur and Fjörður, Hafnarfirði. Another aim was to estimate migraine prevalence in primary care clinics in the capital area of Iceland over the period 2010-2019 and describe prescriptions for migraine specific drugs and other drugs used for migraine.

Material And Methods: This is a retrospective study based on data from medical records from the primary care clinics of the capital region of Iceland.

Use of benzodiazepines and benzodiazepine-related drugs in the Nordic countries between 2000 and 2020.

Use of benzodiazepines (BZ) and related drugs is subject to considerable debate due to problems with dependency and adverse events. We aimed to describe and compare their use across the Nordic countries. Data on the use of clonazepam, BZ-sedatives, BZ-hypnotics, and benzodiazepine-related drugs (BZRD) in adults (≥20 years) were obtained from nationwide registers in Denmark, Finland, Iceland, Norway, and Sweden, 2000-2020.

Showcasing MESMER-X: Spatially Resolved Emulation of Annual Maximum Temperatures of Earth System Models.

Emulators of Earth System Models (ESMs) are complementary to ESMs by providing climate information at lower computational costs. Thus far, the emulation of spatially resolved climate extremes has only received limited attention, even though extreme events are one of the most impactful aspects of climate change. Here, we propose a method for the emulation of local annual maximum temperatures, with a focus on reproducing essential statistical properties such as correlations in space and time.

Co-prescribing of opioids and benzodiazepines/Z-drugs associated with all-cause mortality-A population-based longitudinal study in primary care with weak opioids most commonly prescribed.

The risk of mortality associated with the co-prescribing of benzodiazepines and opioids has been explored in a number of papers mainly focusing on strong opioids. The mortality risk associated with the use of weak opioids has not been dealt with to a similar extent. To assess the mortality risk in primary care patients with consistent 3-year co-prescribing of benzodiazepine/Z-drugs (benzodiazepine receptor modulators) and mainly weak opioids (codeine, tramadol).

Meals, Microbiota and Mental Health in Children and Adolescents (MMM-Study): A protocol for an observational longitudinal case-control study.

Recent studies indicate that the interplay between diet, intestinal microbiota composition, and intestinal permeability can impact mental health. More than 10% of children and adolescents in Iceland suffer from mental disorders, and rates of psychotropics use are very high. The aim of this novel observational longitudinal case-control study, "Meals, Microbiota and Mental Health in Children and Adolescents (MMM-Study)" is to contribute to the promotion of treatment options for children and adolescents diagnosed with mental disorders through identification of patterns that may affect the symptoms.

Virtually Augmented Self-Hypnosis applied to endovascular interventions (VA-HYPO): Randomized Controlled Trial Protocol.

Endovascular interventions (EVI) are increasingly performed as minimally-invasive alternatives to surgery and have many advantages, including a decreased need for general anesthesia. However, EVI can be stressful for patients and often lead to anxiety and pain related to the procedure. The use of local anesthetics, anxiolytics, and analgesic drugs can help avoid general anesthesia.

Intergenerational inequities in exposure to climate extremes.

Young generations are severely threatened by climate change.

Structured headache services as the solution to the ill-health burden of headache: 1. Rationale and description.

In countries where headache services exist at all, their focus is usually on specialist (tertiary) care. This is clinically and economically inappropriate: most headache disorders can effectively and more efficiently (and at lower cost) be treated in educationally supported primary care. At the same time, compartmentalizing divisions between primary, secondary and tertiary care in many health-care systems create multiple inefficiencies, confronting patients attempting to navigate these levels (the "patient journey") with perplexing obstacles.

Globally observed trends in mean and extreme river flow attributed to climate change.

Anthropogenic climate change is expected to affect global river flow. Here, we analyze time series of low, mean, and high river flows from 7250 observatories around the world covering the years 1971 to 2010. We identify spatially complex trend patterns, where some regions are drying and others are wetting consistently across low, mean, and high flows.

Body weight changes and longitudinal associations with cognitive decline among community-dwelling older adults.

Introduction: We aim to investigate the longitudinal associations between changes in body weight (BW) and declines in cognitive function and risk of mild cognitive impairment (MCI)/dementia among cognitively normal individuals 65 years or older.

Methods: Data from the Age Gene/Environment Susceptibility-Reykjavik Study (AGES-Reykjavik Study) including 2620 participants, were examined using multiple logistic regression models. Cognitive function included speed of processing (SP), executive function (EF), and memory function (MF).

Soil moisture dominates dryness stress on ecosystem production globally.

Dryness stress can limit vegetation growth and is often characterized by low soil moisture (SM) and high atmospheric water demand (vapor pressure deficit, VPD). However, the relative role of SM and VPD in limiting ecosystem production remains debated and is difficult to disentangle, as SM and VPD are coupled through land-atmosphere interactions, hindering the ability to predict ecosystem responses to dryness. Here, we combine satellite observations of solar-induced fluorescence with estimates of SM and VPD and show that SM is the dominant driver of dryness stress on ecosystem production across more than 70% of vegetated land areas with valid data.

Correction to: A novel method for assessing climate change impacts in ecotron experiments.

The article was published bearing a typographical error to the second author name listed. The author group regret the error and the name should be referenced and credited as Jakob Zscheischler and not the former.

A novel method for assessing climate change impacts in ecotron experiments.

Ecotron facilities allow accurate control of many environmental variables coupled with extensive monitoring of ecosystem processes. They therefore require multivariate perturbation of climate variables, close to what is observed in the field and projections for the future. Here, we present a new method for creating realistic climate forcing for manipulation experiments and apply it to the UHasselt Ecotron experiment.