Publications by authors named "Guat S Chew"
There is an increasing appreciation for the role of the human Y chromosome in phenotypic differences between the sexes in health and disease. Previous studies have shown that genetic variation within the Y chromosome is associated with cholesterol levels, which is an established risk factor for atherosclerosis, the underlying cause of coronary artery disease (CAD), a major cause of morbidity and mortality worldwide. However, the exact mechanism and potential genes implicated are still unidentified.
View Article and Find Full Text PDFCoronary artery disease (CAD) is one of the leading causes of morbidity and mortality globally. In the last few years our understanding of the genetic and molecular mechanisms that promote CAD in individuals has increased with the advent of the genome era. This complex inflammatory disease has well-defined environmental risk factors.
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- The FGF1 gene, mainly found in the kidneys, has been linked to blood pressure (BP) regulation, but its precise biological mechanisms are still unclear.
- A study involving over 14,000 individuals found a significant association between a specific gene variation (rs152524) and both systolic and diastolic BP, as well as with FGF1 mRNA levels in the kidneys.
- Further analysis revealed that higher expression of FGF1 and its variants in the kidneys correlates with higher BP, along with interactions with partner genes that are also related to BP regulation.