[Effect of chitosan on the level of ROS in HepG2 cell induced by cadmium chloride].

Objective: To study the effect of chitosan on ROS levels in HepG2 cell induced by cadmium chloride.

Methods: The experiments were divided into 6 groups: normal control group, cadmium chloride group (20micromol/L), chitosan group (0.50mg/ml) and three combined treatment group (cadmium chloride 20micromol/L and chitosan 0.

[Oxidative stress of human derived fetal hepatocytes induced by product of chlorinated drinking water (MX)].

Objective: To study the oxidative stress induced by 3-chloro-4-( dichloromethyl)-5-hydroxy-2 [5H]-furanone (MX) (a product of chlorinated drinking water) in human derived fetal hepatocytes (L-02) in vitro.

Methods: L-02 cells were treated at the doses of 10, 30, 100 and 300 micromol/L of MX for 24h. Malondialdehyde (MDA), reduced glutathione (GSH) and 8-hydroxydeoxyguanosine (8-OHdG), the representative of antioxidative molecules and the marker of DNA oxidative damage respectively, were detected in L-02 cell treated by MX.

[Effect of prenatal lead exposure on the expression of POU-domain proteins in different brain regions of rat offsprings].

Objective: To study the role of POU-domain proteins in the neurotoxic mechanism of lead. Methods The pregnant rats were randomly divided into 4 groups, which were provided with distilled water, 0.5g/L, 1.